Objective To explore the influence of continued case nursing on medicine compliance and disease relapse of patients with schizophrenia.Methods Eighty patients with schizophrenia were divided into experiment group and control group according to admission sequence and random digit table,with 40 in each group. Both groups received case management. The control group received routine outpatient visit.The experiment group received continued nursing of primary nurse’s case management based on traditional method for a year.The two groups were compared in terms of the medicine compliance and disease relapse.Result The medicine compliance of the experiment group was higher than that of control group and the disease relapse of the experiment group was lower than that of control group(P<0.05).Conclusion The continued case nursing to patients with schizophrenia can increase medical compliance and reduce incidence of disease relapse,which is an effective hospital-community management mode.