Objective This study aimed at evaluating the safety and feasibility of transumbilical single site laparoscopic appendectomy (SSLA) by systematic review and Meta analysis of literature comparing with conventional tree-port laparoscopic appendectomy (CLA).Methods The articles published from January 2000 to December 2012 were searched from electronic databases of PubMed,Embase,and the Cochrane Library.The literature with comparative studies of SSLA with CLA for adult patients was selected.And,the systematic review and Meta analysis carried out using Stata software.Results Eleven articles with 998 cases receiving operation during March 2008 to October 2011 were enrolled into study.There were 435 cases with SSLA and 563 cases with CLA.Compared the cases with SSLA and cases with CLA,there was no difference significantly in operative time (z =1.48,P =0.140),pain score in the 24 hours after surgery (z =0.83,P =0.409),diet start(z =0.38,P =0.707),postoperative complications (z =0.46,P =0.647),hospital stay (z =0.36,P =0.722).Conclusions SSLA are not different in operative time,postoperative pain,diet start,postoperative complications,hospital time comparing with that in CLA.