Serpiginous choroiditis (SC) is infrequent, chronic and posterior uveitis displaying a geographic pattern of choroiditis easy to recur. Studies reveal that the active lesions of inflammatory processes are mainly localized to the choriocapillaris and retinal pigment epithelium cells. SC may manifest with variable features, although a creeping pattern of choroiditis, extending from the juxtapapillary area, with grayish yellow discoloration. Fundus fluorescein angiography, indocyanine green angiography, fundus auto-fluorescence and optical coherence tomography are helpful to diagnose atypical SC. In addition, these image examinations can evaluate the activity and progression of lesion, and detect any complication that might occur. SC is mainly distinguished from multifocal SC related with tuberculosis or virus and etc. Pathogenesis is unclear, an organ-specific autoimmune inflammation or infection seems likely to be the underlying process. It is mainly using glucocorticoid with immunosuppressant therapy at present. Timely and effectively control inflammation can effectively prevent vision loss, choroidal neovascularization and choroidal scar in SC patients.

With the understanding of the immune inflammatory response in the pathogenesis of dry eyes, and the limitations of widely used artificial tears and numerous pharmaceuticals and methods to promote tear secretion, clinicians pay more attention to the therapies that can promote tear secretion actively. Acupuncture treatment for dry eye may meet this requirement.

OBJECTIVE:To investigate the decoction amount changes of verbascoside,gallic acid in single decoction and com-bined decoction of rehmanniae radix preparata,corni fructus and poria,and provide scientific basis for further study of effective substance basis. METHODS:The single decoction,combined decoction with each 2 medicine and combined decoction with the 3 medicines of rehmanniae radix preparata,corni fructus and poria,were respectively prepared. HPLC was adopted to detect and com-pare the decoction amount of active component verbascoside in rehmanniae radix preparata and active component gallic acid in cor-ni fructus in each group. RESULTS:Compared with single decoction of rehmanniae radix preparata,the decoction amount of ver-bascoside was decreased in combined decoction of poria+rehmanniae radix preparata(P<0.01),decoction amount of verbascoside was increased in combined decoction of corni fructus+rehmanniae radix preparata or combined decoction with the 3 medicines(P<0.01). Compared with single decoction of corni fructus,the decoction amount of gallic acid in each combined decoction was de-creased (P<0.01). CONCLUSIONS:The combined decoction of rehmanniae radix preparata,corni fructus and poria has certain promotion and inhibition effects on the decoction of verbascoside in rehmanniae radix preparata and inhibition effect on the decoc-tion of gallic acid in corni fructus. It is speculated verbascoside may be one of the main components in combined decoction playing the role of effectiveness.

Objective To study the change of cornea superficial temperature of herpes simplex keratitis( HSK) rabbits and the relationship between corneal temperature with cornea lesion.Methods The right eyes of the 12 rabbits that were diagnosed as HSK by being inoculated HSV-1KOS virus to the cornea were brought into the experiment group.The 12 right eyes of the control group were dealt with incision on the cornea epithelial layer without virus.The corneal temperature was measured with the infrared thermometer. The scale of epithelia damage, lesion of stroma and neovascular were observed before and at the 1st day, 3rd day, 7th day, 14th day after establishment of the HSK model.Results The cornea superficial temperature of herpes simplex keratitis was 31.14 ±1.12℃.The temperatures at the 3rd day, 7th day, 14th day were all higher than those of the control group (P<0.01, P<0.05).The stroma opacity were rather serious at the 3rd day, 7th day, 14th day, and the temperatures of the 3rd day and 7th day were relevant to the degrees of stroma opacity(P<0.05).The neovascular was significantly increased at the 14th day, which was relevant to the cornea temperature ( P<0.05) .Conclusion The cornea superficial temperature was increased in the case of herpes simplex keratitis, and the temperature was relevant to the degree of stroma opacity and neovascular.