Objective To investigate the survival status and related influencing factors of very low birth weight infants(VL-BWI) and very early preterm infants(VPI).Methods One hundred and forty-two very low birth weight and very preterm infants in our hospital from April 2012 to January 2016 and contemporaneous 140 non-low-birth-weight and non-very-preterm infants were selected.The survival status of newborns and long-term prognosis were compared.The low birth weight children and very preterm infants were divided into the death group and survival group according to the survival status and long-term prognosis.The clinical data in the two groups were performed the univariate and multivariate Logistic regression analysis.Results The incidence rate of poor prognosis had statistically significant difference among neonates with birth weight less than 1 500,1 500-2 500 and＞2 500 g(P＜0.05).The incidence rate of poor prognosis had statistically significant difference among neonates with the gestational age≤32 weeks,32-37 weeks and≥37 weeks(P＜0.05).The proportions of gestational age,birth weight and antenatal dexamethasone use in the death group were significantly lower than those in the survival group,while the proportions of maternal age,asphyxia,meconium aspiration,pregnancy induced hypertension and mechanical ventilation in the death group were significantly higher than those in the survival group,the difference between two groups was statistically significant(P＜0.05).The gestational age≤28 weeks,birth weight≤1 000 g and asphyxia were the independent risk factors affecting the survival status in very low birth weight infants and extremely preterm infants(P＜0.05).Conclusion In VLBWI and VPI the living status,and long-term prognosis are poor and prone to mental and movement disorders.