Objective To investigate the features of event-related potentials (ERP) P300, auditory evoked potential(AEP) and brainstem auditory evoked potential(BAEP) in senile depression patients and the dynamic chan-ges before and after treatment of sertruline. Methods P300, AEP and BAEP were recorded in 31 senile depression patients using Chinese WOND 2000C Instrument, and a comparison between the patients and 33 normal controls in terms of these evoked potentials were made. Some of the depression patients treated with oral intake of sertraline were followed electophysiologically after 12 months of treatment. Results Compared with normal controls, senile depres-sion patients showed delay of latency of P300-P3 and BAEP-Ⅲ, decreased amplitude of P300-P3, AEP-P2 and BA-EP-Ⅲ(P <0.05 or 0.01). The 12-month follow-up measures of ERP showed significant improvement in terms of la-tency and amplitude of P3/P300,AEP-P2 and BAEP-Ⅲ after treatment of sertraline. Conclusion Senile depres-sion patients showed abnormality on several ERP indexes (such as P3/P300, AEP-P2 and BAEP-Ⅲ), and these in-dexes might provide important evidences to monitor the effect of medicine.

Objective To explore the plasma level of retinol binding protein 4 (RBP4) in patients with es-sential hypertension (EH) of Xinjiang Kazakans and the relations between plasma RBP4 level and blood pressure, blood lipids,blood glucose, insulin, and HOMA-IR. Methods 81 Kazakans cases who were investigated between August and November of 2008 were selected as subjects. They were divided into EH group(n=41)and control group (n=40). Blood pressure was measured. Fasting venous blood was drawn to detect the plasma RBP4, fasting insulin (FINS), fasting plasma glucose(FPG), total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol (HDL-C)、low density lipoprotein cholesterol (LDL-C), apoprotein-A1 (APO-A1) and apoprotein-B (APO-B), and concentration in EH group was significantly higher than that in control group[ (32.74±9.93) mg/L vs (21.92± pressure (DBP),FPG,and HOMA-IR in EH group(r,=0.618,0.775,0.565,0.317,0.369,P<0.01 or P< showed that SBP was independent factor to affect the RBP4 level in EH group(Standardized Coefficients is 0.591, t=5. 695, P=0.000). Conclusion The plasma RBP4 concentration is increased in patients with EH of Kazakans, and is positively correlated with SBP,DBP,FPG,HOMA-IR in EH group. RBP4 may involve in the development of EH by promoting insulin resistance.

Objective · To explore the correlation of serum S100B protein with depressive episode of bipolar disorder (BD) and its prognosis.Methods· Based on BD criteria of Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-Ⅳ),80 patients with depressive episode of BD (case group) and 42 healthy controls (control group) were enrolled.Patients were randomly assigned into quetiapine group who were treated with lithium and quetiapine and modified electroconvulsive therapy (MECT) group who received lithium and MECT.The serum S100B level and Hamilton Rating Scale for Depression (HAMD) were assayed before and after 4-week treatment.Results· The serum S100B levels before treatment in patients with depressive episode of BD were significantly higher than those in healthy controls (P=0.000).The levels of S100B in both drug and MECT groups decreased after 4-week treatment.The HAMD score after treatment significantly decreased than that before treatment (P=0.000).Pearson correlation analysis showed that the change of S 100B level was positively correlated with the change of HAMD score before and after treatment in case group (r=0.33,P=0.013).Conclusion· S100B may be associated with depressive episode of BD and its prognosis.