Occupational Health

It is one heated topic to enhance the humanistic quality of current college students.This paper investigates and analyzes the status quo of humanistic education among the college students in two medical colleges in Tianjin city,exploring related issues in the humanistic education in the English language lecture teaching in medical colleges.

Asthma is heterogeneous disorder which caused by a complicated interaction between multiple genes and environmental factors. A increasing number of attention has paid in the researches about its pathogenic mechanism and therapeutic strategies. Not only can Toll-like receptors and signal transduction pathways mediate relevant immunocyte of asthma, but also induce or restrain development of asthma. TLRs is a land of pattern recognition receptor(PRRs), which can rely on the conserved sequence of gene encoding to identify pathogenic microorganism, meanwhile activate innate immunity,adjust acquired immunity and induce immune tolerance.

Animals ; Breast Neoplasms ; metabolism ; pathology ; Cell Adhesion ; Cell Line, Tumor ; Chemokine CXCL12 ; metabolism ; Chromosomes, Human, Pair 2 ; Humans ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasms ; metabolism ; pathology ; Neovascularization, Pathologic ; Receptors, CXCR ; genetics ; metabolism ; physiology

Breast Neoplasms ; diagnosis ; therapy ; Combined Modality Therapy ; Female ; Humans ; Mammography

The medication record of Chinese medicine is not only a complete record of the clinical practice of clinical pharma-cists, but also the essential data for clinical pharmacists to carry out pharmaceutical care. However, at present, there is no unified standard for the medication record of Chinese medicine. Based on the purpose, significance, content and focus, the paper made pre-liminary discussion on the writing of medication record of Chinese medicine, which bulit a preliminary framework for the writing of med-ication record of Chinese medicine.

Objective To compare the outcomes of operative with non-operative treatment for thoracolumbar burst fracture without neurological deficit using Meta-analysis.Methods Electronic database were searched from inception to February 2014 by two independent reviewers,including Pubmed Medline,Excerpta Medica Database (Embase),Cochrane Central Register of Controlled Trials,Chinese Biology Medicine (CBM),Chinese Wanfang Database,and China National Knowledge Infrastructure (CNKI).Inclusion and exclusion criteria were applied to select the studies.Quality appraisal and data extraction were based on Cochrane Collaboration guidelines.Results Two randomized controlled trials (RCTs),which reported outcomes for 79 patients (41 with operative treatment and 38 with nonoperative treatment) at a follow-up of two years or more were included.Between-study heterogeneity was found to be significant,for one reported better results in surgery group concerning pain relief,function recovery and returning to work.However,opposite results were found in another trial.Meta-analysis showed surgery led to higher complication rates (RR =2.85,95％ CI 0.83-9.75),including subsequent surgery (RR =8.39,95％ CI 1.12-62.87).Conclusion Operative and nonoperative managements produce similar results with respect to pain relief,function regain,and returning to work when performed for thoracolumbar burst fractures without neurologic deficit,but operation is often associated with more complications.

ObjectiveTo observe the effects of mechanical ventilation with different tidal volumes (VT) on coagulability and fibrinolytic characteristics in rabbits with acute respiratory distress syndrome (ARDS) induced by two-hits with oleic acid (OA) and lipopolysaccharide (LPS).Methods Forty healthy adult male rabbits were randomly divided into five groups (8 rabbits in each group): sham operation group, model group, low VT group (6 mL/kg), rontine VT group (10 mL/kg), high VT group (15 mL/kg). ARDS model was reproduced by sequential injection of 0.1 mL/kg OA and 500μg/kg LPS via auricular vein, and the rabbits in sham operation group received normal saline in same volume. Mechanical ventilation was performed in different VT groups after model reproduction, and the end of the experiment was determined as 6 hours after LPS injection. Blood was collected from the carotid artery at 30 minutes and 360 minutes after LPS injection, with which arterial partial pressure of oxygen (PaO2) was determined, and oxygenation index was calculated. Internal jugular vein blood was collected at 5, 120, 240, and 360 minutes after LPS injection, and activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (Fib) and antithrombinⅢ(AT-Ⅲ) were determined. The blood was collected at the end of the experiment, and then the rabbits were sacrificed, and serum levels of procollagen typeⅢ (PⅢP), plasminogen activator inhibitor-1 (PAI-1) as well as PⅢP level in lung tissue were determined. The wet/dry weight ratio (W/D) of lung tissues was calculated.Results Compared with sham operation group, oxygenation index at both 30 minutes and 360 minutes were significantly decreased in model group, while W/D ratio was significantly increased. PT and APTT at 5 minutes were significantly shortened followed by a gradual increase. Fib and AT-Ⅲ showed no change at 5 minutes followed by a gradual decrease, while serum PAI-1 and PⅢP as well as PⅢP in lung tissue were significantly increased. There was no significant difference in oxygenation index between all VT groups and model group, with a tendency to increase in low VT group. W/D ratio in low VT group was the lowest (5.09±0.19), and it was significantly lower than that of the model group (6.02±0.27, P< 0.01), while it was the highest in high VT group (6.27±0.32). PT and APTT in all VT groups were gradually prolonged, and Fib and AT-Ⅲ were gradually decreased. PT and APTT in low VT group were significantly shorter than those in model group from 120 minutes on [PT (s): 120 minutes: 8.90±0.28 vs. 11.43±0.28, 240 minutes: 9.18±0.21 vs. 11.99±0.50, 360 minutes: 9.25±0.15 vs. 12.49±0.29; APTT (s): 120 minutes: 69.09±3.91 vs. 76.08±4.21, 240 minutes: 67.53±2.14 vs. 79.71±2.25, 360 minutes: 66.95±1.13 vs. 83.21±4.01, allP< 0.05], Fib (g/L) was significantly elevated (120 minutes: 3.80±0.09 vs. 3.38±0.15, 240 minutes: 3.91±0.05 vs. 2.47±0.16, 360 minutes:4.06±0.13 vs. 2.39±0.16, allP< 0.05), and no significant difference was found in AT-Ⅲ. Serum contents of PAI-1 and PⅢP as well as PⅢP in lung tissue were significantly lowered [serum PAI-1 (ng/L): 1.14±0.26 vs. 1.63±0.91, serum PⅢP (ng/L): 1.62±0.52 vs. 2.91±0.64, lung PⅢP (ng/L): 4.40±0.58 vs. 5.75±0.47, allP< 0.01]. The change tendency of all parameters in routine VT group was lower than that in low VT group, PT at 120 minutes and 360 minutes, APTT at 240 minutes and 360 minutes was significantly shorter than that in model group, and Fib at 120 minutes and 240 minutes were significantly higher than those in model group (allP< 0.05). No significant difference was found in AT-Ⅲ, serum PAI-1 and PⅢP as well as lung PⅢP as compared with model group. PT and APTT at 360 minutes in high VT group were significantly longer than those in model group, Fib at 360 minutes was significantly lower than that in model group, and lung PⅢP was significantly higher than that in model group. Conclusions There are some important changes in coagulability which changes from a hyper state into a hypo coagulate state, while fibrinolysis is inhibited during the pathological process of ARDS produced by two-hit of OA and LPS. Mechanical ventilation with low VT can obviously improve coagulability and fibrinolytic status, while ventilation with routine VT has little effect on coagulability and fibrinolytic status. Mechanical ventilation with high VT, however, will greatly deteriorate the coagulability and fibrinolytic function in ARDS.

With regard to the traditional processing of pilose antler, two big companies of Chinese Medicine decoction pieces and one private patrimonial TCM clinic were investigated. The result indicates that the processing techniques in these three regions can be found in the ancient books of TCM and belong to the traditional processing of Chinese Medicine, but the processing procedures are different. On the basis of that, starting with the different manifestation forms of regional culture, the author discusses the effect of regional culture on the traditional processing of Chinese Medicine. The research indicates that, different geographical nature environments result in the three specific aspects, which are the specific resources and products, the specific historical culture, and the specific characters. These three specific aspects result in different tools, conventional supplementary materials and techniques of processing, and on the basis of this, different traditional processing schools of Chinese Medicine come into being with different characteristics. Therefore, to protect the traditional processing of Chinese Medicine in different regions has important significance to supplement the deficiencies in Pharmacopoeia of PRC (2010 edition) and the TCM processing standards of different provinces and municipalities, and to bequeath and develop the different characteristics of different processing schools, and it's a full embodiment to carry out the core spirit of National Intangible Cultural Heritage Law.

Objective To investigate the effect of comprehensive treatment and prognosis guide in children with febrile seizures caused by upper respiratory infections.Methods 58 cases of children with febrile seizures caused by upper respiratory infections were divided into the two groups using a random number table method,and the control group received routine first aid and treatment,while the observation group took comprehensive treatment and prognosis guide.The clinical efficacy and recurrence were compared.Results The observation group's abatement of fever time,seizures disappear time and average length of stay was (30.15 ±2.78)h,(4.25 ±0.63)d and (6.51 ±0.52) d,which were significantly less than those of the control group [(45.43 ± 3.14) h,(7.11 ± 0.72) d and (10.02 ± 0.67) d] (t =10.21,9.62,10.30,all P ＜ 0.05) ; The observation group's relapse rate was 13.79％ after treatment,significantly lower than 31.03 ％ of the control group (x2 =11.23,P ＜ 0.05).Conclusion The comprehensive treatment combined with prognosis guide has significant effect in the treatment of children with febrile seizures caused by upper respiratory infections,which can significantly improve clinical symptoms,reduce relapse after treatment.So it has a better clinical value.