In order to achieve the demand of clinical diagnosis,treatment and research based on TCM clinical literature,we conducted the questionnaire to doctors of Chinese medicine on their demands for medical information in the process of clinical diagnosis and treatment,hoping to make certain the direction and service methods of TCM clinical research database from the actual demands of doctors.

Objective To investigate the causes and characteristic of placental abruption.Methods Clincal data of 52 patients with placental abruption were retrospectively analyzed.Results Compared with other incentives,gestational hypertension disease(especially in the severe group)had a significant difference (P ＜ 0.05),but in this group of materials due to placental premature rupture caused by placental abruption are light;on two groups of children to mode of delivery were compared,the difference was statistically significant (P ＜ 0.05) ;on two groups of maternal postpartum were compared,the difference was statistically significant (P ＜ 0.05) ; the two group of fetuses were compared,the difference was statistically significant(P ＜ 0.05).On 7 cases of fetal asphyxia of active treatment were cured.Conclusion In order to further reduce the incidence of placental abruption should the knowledge of this disease is caused take seriously,strengthen to the prevention of the disease as well as publicity and education,and further improve the prenatal diagnosis and treatment level,as the child 's life to provide security protection.

Bispheno|A(BPA)is an endocrine disruptor with estrgenic properties,which is a widely used industrial platicizer.When exposure to BPA for long-term,it would impact on multiple systems and organs including reproductive.developmental,neurological,endocrine function and so on,particularly in obesity.ExpoSUre to BPA during pregnancy and postnate,it can increase the sensitivity to obesity in offsprings.BPA may be contributed to obesity by enhancing triglyceride accumulation and accelerating adipocytes differentiation,affecting endocrine function of adipocytes and blood glucose and insulin metabolism.However,the dosage effect of BPA is not a simple linear rehionship.The impact of environment-related dosage on the human is worthy ot research in future.

Real-time three-dimensional echocardiography(RT-3DE) has been validated for its accurate diagnoses and quantitave mearsurement of mitral valve disease,which could act as a guide in selecting the proper therapeutic strategy for each individual in clinical setting.In this article,the recent research achievements on RT-3DE in mitral valve disease were summarized,and the application of RT-3DE in surgical approach to mitral valve disease was discussed as well.

Age-related macular degeneration (AMD) can cause irreversible severe visual impairment.At present,a large number of basic and clinical research has documented several effective treatment for wet AMD.As for dry AMD,so far there is no effective therapy and preventive measure.Dry AMD probably worse for macular choroidal neovascularization (CNV) or geographic atrophy (GA) to its later stage,resulting in severe visual impairment.In recent years,some promising treatment strategies are emerging,mainly in the prevention of the damage of photoreceptor and retinal pigment epithelium,such as drug therapy,laser photocoagulation,surgery,plasma exchange,stem cell transplantation and gene therapy.These therapies are expected to be able to bring hope for arresting the development of dry AMD.This article reviews the current researches and possible future management of dry AMD.

OBJECTIVE:To evaluate the rationality of drug use in cancer patients in Tiantan Hospice Hospital.METHODS:By a retrospective study,the drug use in cancer patients in Tiantan Hospice Hospital who died during Jan.2008 and Sep.2008 were analyzed statistically.RESULTS & CONCLUSION:The drug use in cancer patients in Tiantan Hospice Hospital was rational on the whole.Step medication,oral medication,on time medication and individual medication were realized in Beijing Tiantan Hospice hospital and treatment on cancer patients in this hospital was in line with the Guideline for Cancer Pain Management Based on the Three-step Analgesic Ladder recommended by WHO.

ObjectiveTo compare the clinical efficacy and side effects of liver damage of the methylprednisolone (methylprednisolone tablets ) and prednisone treating nephrotic syndrome compicated with hepatitis B.Methods66 patients with nephrotic syndrome complicated with hepatitis B were randomly divided into control group and observation group,and each group had 33 cases.The control group was given prednisone in the morning,while the observation group was received methylprednisolone.The clinical efficacy and side effects of liver damage were compared between the two groups.ResultsAfter the treatment,the biochemical index significantly improved compared with the pre-treatment( all P ＜ 0.05 ) ;The total effective rate of observation group was 93.94％ higher than 84.85％ of the control group( x2 =1.44,P ＞ 0.05 ).However,there was no significant difference between the two groups( P ＞0.05) ;The observation group was significantly higher than the control group in negative rate of HBV-DNA (x2 =4.69,P ＜ 0.05 ) ;The side effects of liver damage in the observation group were lower than the control group (t =5.62,5.13,P ＜ 0.05 ).ConclusionMethylprednisolone and prednisone for treating patients with nephrotic syndrome compicated with hepatitis B had good clinical efficacy,and methylprednisolone was more effective than prednisone,especially it had less side effects of liver damage than prednisone.

Objective:To investigate the effect of sonodynamic therapy with hematoporphrin on the expression of VEGF in Chick Chorioallantoic Membrane and provide experimental basis for appling sonodynamic therapy(SDT)on anti-angiogenesis in tumor therapy.Methods:The hatching eggs cultured for 7 days were randomly divided into 4 groups:blank control group,ultrasound group,hematoporphrin group,sonodynamic therapy group.The express of VEGF in CAM was detected by immunity histochemistry.Result:There were significant differences between control group and ultrasound group(P0.05),conclusion The results show that sonodynamic therapy with hematoporphrin has a significant inhibitionary effect on the express of VEGF in CAM and this maybe is the most important mechanism of its anti-angiogenesis effect.

Collaborative inquiry applied in teaching of literature retrieval course is beneficial for the unity and cooperation between teachers and students,and their independent study ability. Described in this paper is the collabo-rative inquiry in teaching of information retrieval course with its target, methods and program carefully designed for medical postgraduates according to the students-oriented construction theory, which can promote the growth up of teachers and students, and learn the frontier and innovative theories, and practical knowledge.

Objective:To establish an HPLC method for the determination of two components in aspirin and phenobarbital pow-ders.Methods:AThermoBDSC18column(250mm×4.6mm,5μm)wasusedwithacetonitrile-methanol-0.01mol·L-1KH2PO4so-lution -triethylamine(10∶35∶55∶0.1)(adjusting pH to 3.5 with phosphoric acid )as the mobile phase. The flow rate was 1.0 ml· min-1 and the detection wavelength was 242nm. The column temperature was ambient and the injection volume was 20 μl. Results:There was a good linear relationship when the content of aspirin and phenobarbital was within the range of 0. 402 0 ~1. 608 0 mg· ml-1(r=0.999 7) and 0.061 2 ~0.244 8 mg·ml-1(r =0.999 6), respectively. The average recovery was 99.21%(RSD =0. 49%,n=9) and 99. 63% (RSD=0. 39%,n=9), respectively. Conclusion:The method is simple and accurate with good repro-ducibility, and can be used to control the quality of the preparation.