This article was aimed to interpret the composition of Mahuang Decoction. The analysis was made on key points of medication, herbal combination, weigh ratio, the combined prescription treatment of Taiyang cold damage syndrome (wind-cold exterior-excess pattern) and heart-heat syndrome, heart-yang deficiency, heart-blood defi-ciency, heart-yin deficiency, liver-heat syndrome, liver-cold syndrome, liver-blood deficiency, liver-yin deficiency, spleen-stomach stagnated heat syndrome, spleen-stomach cold deficiency, spleen-stomach qi and yin deficiency, lung-heat syndrome, lung-cold syndrome, lung-yin deficiency, lung qi and yin deficiency, kidney qi insecurity, kid-ney-yang deficiency, kidney-yin deficiency, kidney yin-yang deficiency syndrome. Attention should be paid to use Mahuang Decoction as the combined prescription to receive the best treatment effect in the clinical practice.

Obstructive sleep apnea-hypopnea syndrome ( OSAHS) is a prevalent disorder often associated with multisystem dys-function.Available therapies are limited by either lack of long-term adherence or low response rates .Two emerging therapies hold promise in providing alternatives to patients with OSA .The first stems from the importance of the upperairway dilator muscles in main-taining pharyngeal stability .Electrical stimulation of the genioglossus muscle improves both upper-airway diameter and ameliorates pha-ryngeal obstruction .The results of phase ⅠandⅡclinical trials hold promise , but the reported improvements in the apnea-hypopnea index vary between subjects and long-term safety needs further studies .The second technology relies on creating an increased expiratory nasal resistance via a bidirectional valve designed to be worn just inside the nostrils .Initial findings of clinical trials suggest reduction in severity of sleep apnea and subjective daytime sleepiness .Considerable heterogeneity in response to the nasal device was noted de-spite the high adherence rates .It remains unclear which patients will likely benefit from these devices .

Magnetic Resonance Imaging (MRI) can form a three-dimensional positioning anatomical imaging.By comparing the tumor volume and signal intensity changes,there is great value of MRI in the assessment of the efficacy of cervical cancer.With the development of imaging,magnetic resonance diffusion weighted imaging (DWI),magnetic resonance spectroscopy (MRS) can provide qualitative and quantitative information of the cellular level,which reflects changes in the treatment of tumor cells.Magnetic resonance imaging can predict early locally advanced cervical cancer neoadjuvant chemotherapy,thus providing an important basis for individualized treatment of patients.

Sorafenib,a novel oral multikinase inhibitor,targts on serine/threonine kinase and tyrosine kinases receptor of the tumor cells and vasculature.So Sorafenib can inhibit the tumor cell proliferation and revascularization.400 mg sorafenib administered twice a day is chosen as the recommended dosage for several phase Ⅰ studies,and it shows broad-spectrum antitumor activity in renal cancer,hepatocellular carcinoma,melanoma and non-small-cell lung cancer(NSCLC)in phase Ⅱ and Ⅲ clinical trials.Now FDA has approved the usage of sorafenib in renal cancer therapy.

Objective: To study the mental health status and influential factors of elderly people in the rural areas. Methods: 714 elderly people were tested by the SCL-90. Results: All the factor scores of SCL-90 of the elderly people in the rural areas were higher than those of the retired people. Some factor scores of SCL-90 of elderly people showed significant differences because of existence of spouse, physical health, filial piety of sons and daughters, and economic independence. Conclusion: The mental health status of elderly people in the rural areas is poorer than that of retired people. Existence of spouse, physical health, filial piety of sons and daughters and economic independence all influence the mental health of elderly people in the rural areas.

An endogenous suppressor of apoptosis, the inhibitor of apoptosis proteins(IAP) plays a key role in the occurrence and progression of cancer. In recent years cancer researches have been focused on gene-specific inhibitors with IAP as the target, so as to seek gene therapeutic strategies of less toxicity and higher efficiency. As members of IAP family, survivin and livin are over-expressed in tumors. Meanwhile, Smac can directly inhibit IAP. These findings suggest a promising alternative strategy for developing novel anticancer therapies.-

[Objective]To investigate the effects of bone marrow stromal stem cells(MSCs) on the bone defect around the implant and the osteointegration of implant-bone interface.[Method]Fifteen healthy clean New Zealand rabbits were studied.MSCs were separated,cultured and induced to osteoblasts.Cancellous bone defects(0.6?1.2 cm)were created in bilateral femur condyle in rabbits.Titanium alloy columns(0.3?1.0 cm)were implanted into both defects.Tissue engineering bone was implanted around the left titanium alloy implant,but only hydroxyapatite ceramic in the right.The biological characteristics were evaluated by X-ray examination,SEM,energy dispersive X-ray analysis and histologic studies at 4,8,and 12 weeks postoperatively.[Result] X-ray examination showed the density of bone tissue around the implant was aequalis.The interspace between implant and bone was filled with lots of bone trabeculae in the experimental group at 12 weeks postoperatively.The density of bone tissue was inhomogeneous,and low-density umbra existed in the interspace in the control group.Energy dispersive X-ray analysis showed the content of the Ca and P in the experimental group was statistically higher than that in the control group at different time points(P0.05.The ratio of Ca to P became higher and reaching the peak level at 8 week.Histological study showed the bone defects around the implant were repaired by new mature bone in the left at 12 weeks postoperatively,while in the right no new bone was found at any time point.[Conclusion]The compounds of hydroxyapatite ceramic and osteoblasts induced by MSCs can repair the bone defect around the implant and improve the osteointegration of implant-bone interface.

[Objective]To dynamically monitor revascularization and metabolism of tissue-engineered bone graft in repairing bone defects by radionuclide bone imaging.[Method]Twenty-four healthy New Zealand rabbits were studied.Mesenchymal stem cells(MSCs) were separated and cultured from bone marrow.Cancellous bone defects(0.6 cm?1.2 cm) were created on bilateral femoral condyles in rabbits.The compound of coral hydroxyapatite ceramic(CHA) and defects were treated with the induced osteoblasts inplanted into the left defects(experimental group).While CHA alone was used for the right(control group).The counts of regions of interest(ROI) was evaluated by radionuclide bone imaging at 4,8 and 12 weeks postoperatively.[Result]ROI in the experimental group was significantly higher than that of control group at 4,8 and 12 weeks postoperatively.ROI in either group had a tendency to increase with time.Eight weeks postoperatively,ROI in experimental group tended to increase at a lower speed,while ROI in control group had a tendency to increase at a higher speed.ROI in either group reached a peak at 12 weeks postoperatively.[Conclusion]The tissue-engineered bone graft is an effective method for repairing cancellous bone defects.Radionuclide bone imaging can dynamically monitor the changes of revascularization and metabolism of tissue-engineered bone graft.

OBJECTIVE:To investigate the use of antibiotics in our hospital.METHODS:The data regarding the use of antibiotics retrieved in July 2006 from 184 discharged histories were analyzed retrospectively.RESULTS:The application rate of antibiotics in our hospital reached 77.3%,of which,34.6% were used in combination of two kinds,and 32.6% were used in combination of three kinds.Only 5.9% of the specimens had been sent for pathologic examination.CONCLUSION:The application rate of antibiotics in the inpatients of our hospital as well as the postoperative use of antibiotics were all on the high side,while the rate of specimens sent for pathologic examination was on the low side,therefore,it is urgent to strengthen control on the rational use and standardized management of antibiotics.

OBJECTIVE: To establish an HPLC method for the determination of Matrine in Baishan tablets. METHODS: The analytical column was Aminopropyl (200 mm?4.6 mm, 10 ?m) with mobile phase consisted of acetonitrile-0.5% phosphate solution - ethanol(100∶8∶10) at a flow rate of 1.0 mL?min-1. The column temperature was set at 30 ℃ and the detection wavelength was set at 220 nm. RESULTS: The linear range of Matrine was 0.27～ 8.66 ?g(r=0.999 8) and the average recovery of Matrine was 99.52 %(RSD=0.91%,n=6). CONCLUSION: The method is simple, accurate and reproducible, and it is applicable for the quality control of Baishan tablets.