Tumor progression is often associated with immune suppression or the ability of the tumors to avoid immune surveillance.Immunotherapy improves the ability of the immune system to recognize and clear tumor cells with a little influence on the normal tissues.Immunotherapy is a hot spot in the research of advanced esophageal cancer.Innnunotherapy of esophageal cancer includes immune checkpoint inhibitors,adoptive cellular immunotherapy,tumor vaccines and antibody therapy.At present,a large number of clinical trials are underway to evaluate the role of immunotherapy in esophageal cancer.Checkpoint inhibitors represented by Pembrolizumab and Nivolumab,has achieved initial success in the treatment of advanced esophageal cancer to improve the prognosis and life quality of esophageal cancer patients.In the future,further studies are needed to have a research on the effects of tumor heterogeneity,prediction of therapeutic targets,and immune tolerance.

Epidermal growth factor receptor(EGFR) family plays an important role in the development of gastric cancer. EGFR-targeted therapeutic agents include extracellular monoclonal antibodies and intracellular tyrosine kinase inhibitors. Many new agents such as trastuzumab, cetuximab, panitumumab and lapatinib, have been tested in randomized phase Ⅲ clinical trials. Results from ToGA trial may shed some light on the treatment of advanced gastric cancer.

Objective To study of vascular false as the clinical effect and safety of acromastitis were treated by com -pound anisodine treatment , to provide reference for the treatment of vascular pseudo optic .Methods From June 2013 to June 2015, 132 cases of patients with vascular pseudo optic papilla in our hospital were selected as the observation objects , and were divided into observation group and control group each 66 cases according to the treatment method .The control group was treated with routine drug therapy , and the observation group in the control group on the basis of daily injections of Com -pound Anisodine Hydrobromide Injection .Two groups before and after the treatment of vision changes , and the treatment of safety and efficacy were compared .Results The curative effect:The two groups of patients after treatment were improved , but the observation group was significantly higher than the control group after treatment ;The cure rate and total effective rate of the observation group were 39.51%and 88.89%respectively, which was significantly higher than the control group of 24. 36%and 73.08%, and had better curative effect in observation group .Security aspect:The total incidence of adverse reac-tions in the observation group and the treatment group was 10.61%, significantly less than 24.24% of the control group, higher safety .Conclusion In the treatment of vascular pseudoaneurysms as papillitis drugs , the curative effect of compound anisodine is much better with better security , which can significantly improve the visual acuity of the patients .

Objective:To study the effect of exogenous hyaluronidase on proliferation of human breast cancer cells in vitro.Methods:The proliferation of human breast cancer cell line ZR-75-30 were detected by MTT-assay and flow cytometry.Results:The absorbency value(A) of ZR-75-30 in study group treated with Hyase (0.674?0.221) was significantly higher than that in control group(0.563?0.046).The percentage of phase S cells in study group(18.36?0.65) was higher than that in control group(2.19?0.10);the percentage of phase G0/G1 cells in study group(44.49?4.33) was lower than that in control group(62.14?26.97).The absorbency value(A) of MDA-MB-435 in study group (0.674?0.221) was significantly higher than that in control group(0.563?0.046).The absorbency valve(A) of MDA-MB-231 in study group (0.674?0.221) was significantly higher than that in control group(0.563?0.046).Conclusion:Exogenous hyaluronidase may promote the proliferation of breast cancer cell lines in vitro.

Arginine ; therapeutic use ; Burns ; therapy ; Humans ; Nutrition Therapy ; Wound Healing

Burns ; Periodicals as Topic ; Surgery, Plastic

The description of the circulation of qiand blood in twelve meridians and the symptoms of diseases in which they dominate inMiraculous Pivot·Meridianshas a certain guiding significance for clinical diagnosis and treatment. But in the book, six yang meridians “dominating in bodily diseases is considered as “fluid”, “humor”, “qi”, “blood”, “sinew” and “bone” dominating in bodily diseases. That is puzzling and prone to doubt. The authors perform a multi-angle analysis from the characteristics of circulation of qi and blood and functional activityof qi in meridians and give a reasonable explanation by referring also to other sections and chapters inHuangdi’s Internal Classic.

Objective To discuss the influences of responsibility administration system by family doctors and nurses on knowledge management and treatment compliance of hypertension patients. Methods Two hunderd hypertension patients (≥40 years old) registered in a community of Shenzhen were selected and randomized into two groups with 100 cases in each group based on the digit random number table. According to the management requirement of Work Manual of Community Comprehensive Prevention and Treatment Project on Hypertension and Diabetes in Shenzhen, patients in the control group were classified for follow-up and management, while the patients in the experiment group signed protocol of family doctor service and were managed by family doctors and nurses in addition to the management by the control group. After 1 year intervention, the two groups were compared in changes of awareness rate of hypertension related knowledge, treatment compliance, blood pressure and BMI. Results The awareness rate of hypertension related knowledge, treatment compliance, blood pressure and BMI in the experiment group after intervention were statistically better than those before intervention (P<0.01). After intervention, those indexes of the experiment group were significantly better than those of the control group (P<0.01). Conclusion Responsibility administration system by family doctors and nurses can effectively improve the awareness rate of hypertension related knowledge and treatment compliance of hypertension patients , thus effectively control the blood pressure.

Myeloid-derived suppressor cells (MDSCs) play an important immunosuppressive role during the tumor development process.And the progression of many tumors are always accompanied with abnormal accumulation of MDSCs.Moreover,both the accumulation and functions of MDSCs could be affected by complicated factors.Therefore,how to effectively reduce the immunosuppressive effects of MDSCs in oncotherapy has become the focus of scholars.Recent studies show that anti-tumor drugs can affect many biological behaviors of MDSCs.

Objective To study the effect of Tongxiening Keli in combination with Birid Triple Viable (BIFICO) in treatment of post-infectious irritable bowel syndrome(PI-IBS) .Methods 112 cases of diarrhea-predominant PI-IBS were divided into combina-tion treatment group(n=60) and control group(n=52) .Combination treatment group received both Tongxiening Keli and BIFICO treatment ,while the control group received BIFICO treatment only .After 6-week treatment ,the therapeutic effect were compared between the two groups .Results The intestinal symptoms grading of combination treatment group was significantly lower than that of control group(P<0 .05);The total effective rate of combination treatment group was 91 .7% ,the total effective rate of con-trol group was 65 .4% ,curative effect in combination treatment group was superior to the control group (P<0 .01) .Conclusion Tongxiening Keli combined with BIFICO is evident effective in treatment of diarrhea-predominant PI-IBS .