1.The clinical analysis of late infection after AF instrumentation
Yue WANG ; Wanchun WANG ; Sanzhong XU
Chinese Journal of Orthopaedics 2001;0(06):-
Objective To study the clinical presentations,risk factors of delayed infection a fter AF internal fixation and find out an eff ective treatment for this complication.Methods Eight cases of delayed infection following AF internal fix ation were reviewed.Clinical sympt oms,laboratory tests and culture re ports were studied.All patients were treated with debridement,instrumentation removal and irrigation.The woun d was primary closed followed by posto perative administration of antibio tics.The specimen obtained in the op-eration was sent to bacteria culture.Results These 8patients experienced develo pment of late infection in10-27months(a mean of 18months)after the initial procedure.The cli nical presentations were variable b ut all patients reported back pain and t he development of draining sinus.Si x patients had elevated erythrocyte sedimentation rate.None had elevated white blood cell counts.After re-operation,all patients gained reli ef of back pain and the wounds were healed u p.Low-virulence skin normal organi sms were yielded in 4cases with general culture.Conclusion These late infections after AF internal fixation may have been caused by i n-traoperative contamination.The in fection affect deep soft tissue with out involving the bone.It can be suc-cessfully treated with debridement ,device removal and irrigation,primary skin closure and short-term an-tibiotics.[
2.Expression and clinical significance of urokinase type plasminogen activator in giant cell tumor of bone
Jian QIN ; Wanchun WANG ; Zhonghe XU ;
Cancer Research and Clinic 2001;0(04):-
Objective To investigate the relationship of uPA and uPA R protein expression in bone giant cell tumors(GCT)with their pathological grades and relapse. Methods By using Avidin biotin complex(ABC) immunohistochemistry method, monoclonal antibodies against uPA and uPA R proteins were used to measure their expression in 23 cases of GCT (including 8 cases of pathological grade Ⅰ, 10 cases of pathological grade Ⅱ and 5 cases of pathological grade Ⅲ accord to Jaffe classification). Results According to the level of these immunoreaction, over expression of uPA and uPA R were detected in 10 and 8 patients (positive rate 43.5 % and 34.8 %). In cases with relapse or not, the positive expression rate of uPA and uPA R was 66.7 %, 28.6 %, 66.7 %, 14.3 % respectively, abnormally high expression of both uPA and uPA R proteins was found in 6 cases(66.7 %). A significant correlation existed between the uPA R expression or co over expression of uPA and uPA R proteins in GCT and its relapse (P
3.Discussion on Electrical Safety and Quality Control of Radio Knife
Yueqi YANG ; Wanchun XU ; Ying QIAN
Chinese Medical Equipment Journal 2004;0(09):-
Fluke Electrical Safety analyzer (ESA-601) and Electrical Surgery analyzer(Model 454A)are used to measure some relative parameters of radio knife. By combining our measuring activity with the problems existing in the daily managements and usage of radio knife,our viewpoints are described in the following four aspects:management rules,electric shock prevention,patient electrode system and output power. An immature scheme about the quality control of radio knife is also put forward.
4.Application of reference methods suggested by IFCC and analysis of the 2006 ring trial results
Tao WANG ; Lili QI ; Haiyan LIU ; Zhen TIAN ; Zhenkun HE ; Shukui LI ; Wanchun DAN ; Guobin XU
Chinese Journal of Laboratory Medicine 2008;31(3):264-269
Objective To establish reference methods for the measurement of catalytic activity concentrations of enzymes at 37℃ which have been published by IFCC and evaluate accuracy of reference methods.Methods Six reference methods for the measurement of catalytic activity of enzymes were established with two sets of apparatus systems of PE and Agilent according to International Federation of Clinical Chemistry(IFCC)37℃ reference procedures in two reference labs respectively.The commercial Roche calibrator c.f.a.s was used to monitor the precision of two reference labs as quality control material.Certified Reference Materials(CRMs)represented an efficient tool to assess the analytic performance for the verification of trueness and in two labs.The measurement accuracy of the assays for catalytic activity concentrations of 6 enzymes [alanine aminotransferase(ALT),aspartate aminotransferase(AST),lactate dehydrogenase(LDH),creatine kinase(CK),gamma-glutamyhransferase(GGT),amylase(AMY)]was further verified and validated by international ring trial program.Results The within-laboratory variations of 6 enzymes in both of the reference lab were ranged from 0.5%-1.9%.Their results showed fully agreement with deviation less than 2.1%.The value of CRM was in the tolerant limit and analytic accuracy was verified.The results of four enzymes(ALT,AST,GGT,AMY)lay within (x)±s.However,the result of CK and LDH lay within (x)±2s.Except sample A for the LDH testing,we did not find any deviation variable in the detection of other enzymes.Conclusions The reference methods for the measurement of catalytic activity of enzymes(ALT,AST,LDH,CK,GGT,AMY)at 37℃ in the two labs by use of two sets of apparatus systems of PE and Agilent have been established and these methods showed excellent stability and accuracy.
5.Performance of IFCC enzyme reference method laboratory network in China
Jing WANG ; Chuanbao ZHANG ; Yi JU ; Baorong CHEN ; Man ZHANG ; Guobin XU ; Wanchun DAN ; Yueguo ZHOU ; Yaohong SONG ; Ziyu SHEN ; Jian GUO ; Wenxiang CHEN ; Zhenhua YANG
Chinese Journal of Laboratory Medicine 2008;31(3):258-263
Objective To review the performance of the IFCC enzyme reference methods in China laboratories and to evaluate the competence of enzyme reference measurement in China.Methods The Intemational Federation of Clinical Chemistry and Laboratory Medicine(IFCC)enzyme reference methods were performed in 8 China laboratories.Reference procedures were developed by each laboratory and the performances were evaluated.The Clinical and Laboratory Stadards Institute(CLSI)EP-5 protocol was used for the evaluation of precision and certified reference materials(CRMS)were used for the verification of trueness.Seven of the 8 laboratories participated in the 2006 IFCC external quality assessment program for reference laboratories(RELA)for the assessment of the measurement performance.Results Within-run CVs of less than 1.5%and between-run CVs of less than 2%were achieved bv all the China laboratories.Results on CRMs by some of the laboratories agreed with the certified value within the stated uncertainty.In the 2006 RELA,the averages and the interlaboratory CVs of the China laboratories were similar to those of international laboratories.Conclusion A preliminary enzyme reference method laboratory network has been established in China.
6.Study on the Application of Named Entity Recognition in Electronic Medical Records for Lymphedema Disease
Haocheng TANG ; Wanchun SU ; Xiuyuan JI ; Jianfeng XIN ; Song XIA ; Yuguang SUN ; Yi XU ; Wenbin SHEN
Journal of Medical Informatics 2024;45(2):52-58
Purpose/Significance The paper discusses the application of artificial intelligence technology to the key entity recognition ofunstructured text data in the electronic medical records of lymphedema patients.Method/Process It expounds the solution of model fine-tuning training under the background of sample scarcity,a total of 594 patients admitted to the department of lymphatic surgery of Beijing Shijitan Hospital,Capital Medical University are selected as the research objects.The prediction layer of the GlobalPointer model is fine-tuned according to 15 key entity categories labeled by clinicians,nested and non-nested key entities are identified with its glob-al pointer.The accuracy of the experimental results and the feasibility of clinical application are analyzed.Result/Conclusion After fine-tuning,the average accuracy rate,recall rate and Macro_F1 ofthe model are 0.795,0.641 and 0.697,respectively,which lay a foundation for accurate mining of lymphedema EMR data.
7.Evaluation from Composite Adaptation of Assistive Devices Program in Shanghai
Zhuang TIAN ; Yu SONG ; Rong JIN ; Bin XU ; Wanchun CHEN ; Heng LI ; Min JI ; Jun LV
Chinese Journal of Rehabilitation Theory and Practice 2016;22(2):221-226
Objective To analyze the results from adopted evaluation of Composite Adaptation of Assistive Devices Program (CAADP) in Shanghai. Methods 1996 potential adaptation objects were evaluated by professional assessment panel with the questionnaire developed by our research group in the early. Results and Conclusion Physical disabilities were the majority. 97.69% of the objects needed different assistance from others or aids in their daily lives, with low quality of life. The assistive devices recommended were an average of 4.3 per person with complete species.