1.The association between the attention deficit hyperactivity disorder (ADHD) symptoms and bully/victim problem among Malaysian sixth-graders
Wan Salwina Wan Ismail ; Nik Ruzyanei Nik Jaafar ; Tuti Iryani Mohd Daud ; Shamsul Azhar Shah ; Aniza Ismail ; ; Zasmani Shafiee
ASEAN Journal of Psychiatry 2010;11(1):79-86
Objective: School bullying in Malaysia is on the rise. While efforts are put together to combat the problem, the psychiatric aspect has been neglected. This is a cross-sectional study aimed to determine the association between the symptoms of ADHD and bully/victim problems among Malaysian sixth-graders attending primary schools in Kuala Lumpur. Methods: A total of 410 sixth-graders from seven randomly selected schools were assessed with regards to bully/victim problems and ADHD symptoms using self-reported questionnaires. Malaysian Bullying Questionnaire was used to rate bully/victim problems while ADHD symptoms were assessed using Conners-Wells’ Adolescent Self-report Scale (CASS). Teachers and parents also assessed students’ ADHD symptoms using Conner’s Teachers Rating Scale (CTRS) and Conner’s Parents Rating Scale (CPRS), respectively. Results: Self-reported questionnaires showed that 61.2% of the children were involved in bully/victim problems. The ADHD symptoms were found significant in relation to bully/victim problems as tested by multiple logistic regression. Only students and parents reported significant ADHD symptoms among the bully/victim groups. The ADHD symptoms reported by students were significant among bullies(OR=0.59,CI=0.42-0.83, p<0.01) and bully-victims(OR=0.55 CI=0.37-0.81,p<0.00). Parents reported significant ADHD symptoms only in victims(OR=1.260,CI=1.02-1.56,p=0.03). Conclusion: The ADHD symptoms were significantly present among bullies, victims and bully-victims. These findings open a new perspective of managing bully/victim problems since effective treatment is available for ADHD.
2.Neurological Disorder Brain Model: A Lesson from Marine Worms (Annelida: Polychaeta)
Mohd Ulul Ilmie Ahmad Nazri ; Izwandy Idris ; Othman Ross ; Wan Iryani Wan Ismail
Malaysian Journal of Medical Sciences 2019;26(6):5-18
The incidence of neurodegenerative diseases is directly proportional to age. The
prevalence of non-communicable diseases, for example, Alzheimer’s and Parkinson’s, is expected
to rise in the coming years. Understanding the etiopathology of these diseases is a crucial step
that needs to be taken to develop drugs for their treatment. Animal models are being increasingly
used to expand the knowledge and understanding on neurodegenerative diseases. Marine worms,
known as polychaetes (phylum Annelida), which are abundantly and frequently found in benthic
environments, possess a simple yet complete nervous system (including a true brain that is
centralised and specialised) compared to other annelids. Hence, polychaetes can potentially be
the next candidate for a nerve disease model. The ability to activate the entire nervous system
regeneration (NSR) is among the remarkable features of many polychaetes species. However, the
information on NSR in polychaetes and how it can potentially model neurodegenerative diseases
in humans is still lacking. By exploring such studies, we may eventually be able to circumvent the
developmental constraints that limit NSR in the human nervous system. This article is intended to
briefly review responsible mechanisms and signalling pathways of NSR in marine polychaetes and
to make a comparison with other established models of neurodegenerative disease.