[Objective] To sum up Mr. Wang Xugao's experience in treating infants diseases. [Method] By analysis on infants medical cases treated by Mr. Wang Xugao such as fetus scare, child tuberculosis, Severe Malnutrition, acute asthmatic attack in children,etc., sum up his features in treating such dis-eases. [Result] In treating infants diseases, he pays attention to differentiation and analysis of organs deficiency and excessiveness, very according with the gist of Mr. Qian Yi's theory of infants physiologytender organs, un-enough Qi bloodand pathology easy deficiency and excessiveness, easy cold and hot. [Conclusion] Mr. Wang's treatment on infants diseases is flexible and changeable, with good cure effect.

[Objective]Analyzing the effect of the theory thought of treating liver diseases from Zhang Zhongjing to Wang Xugao ’s book named“Xixi Library recorded”.[Method]To summarize the methods and experiences of treating liver diseases from Wang Xugao ’s book and to analyze the inheritance of the theory thought of treating liver diseases from Zhang Zhongjing to Wang Xugao.[result]Wang Xugao ’s book originated“the thirty methods of treating liv-er diseases”,based on his methods and experiences;he also generalized “liver qi,liver wind and liver fire ”as the essential points in liver diseases.[Conclu-sion]Dr. Wang Xugao was a famous physician skil ful at liver diseases ,and his theory thought of treating liver diseases basical y came from the theory of Dr. Zhang Zhongjing.

Segmentation of cryo-electron micrograph (Cryo-EM) image is crucial to identification of macromolecular particles. In this paper, the features of Cryo-EM image are discussed and a new automatic segmentation algorithm for Cryo-EM image based on wavelet transformation and difference of Gaussian (DoG) is also provided. This method uses wavelet decomposition to do the multi-resolution analysis, which can depress noise and enhance contrast. After DoG image is segmented by using OTSU method, main edges are selected by the combination of gray and grads information. Experiment results show that the algorithm has good result.

The current situation of education in biomedical engineering in China is introduced.The necessity of training innovative talents is analyzed.The exploration and practice in talents training are introduced including personnel training modes,construction of experiment base,reform of teaching methods and material,training of teachers,participation of scientific research,etc.

The real-time dynamic display of physiological parameters curve is a key element to observing users' various physiological information directly in telemedicine system. The real-time dynamic display of B/S waveform is realized with ActiveX, DelphiActiveForm and network data communication based on Sockets.

As survival of premature infants has increased,nutritional support has become a more prominent component of patient care.Aggressive nutritional strategies can reduce the incidence of extrauterine growth retardation (EUGR),speed up the physical growth and promote the development of intelligence.But excessive weight gain may also increase the risk of obesity and cardiovascular diseases in the future.This review mainly introduces and interprets the enteral nutrient supply for preterm infants:commentary from the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN),2010,to provide an evidence-based medicine nutritional guideline for preterm infants.

OBJECTIVE:To provide references for the improvement of civil relief system for adverse drug reactions.METHODS:The approaches for Japan in handling the "quinoform" drug injury event were compared with the way of China in dealing with drug injury events.RESULTS & CONCLUSION:The approaches for Japan in handling the"quinoform" drug injury event give some hints for China,i.e.the defective drugs should be comprehensively judged by judges,the causal relations should be determined by using the probability theory and the time point of producers' exemption should be revised.

OBJECTIVE:To facilitate the evolvement of Chinese ADR monitoring.METHODS:Approaches concerning prescription-event monitoring in England and its progresses were investigated.RESULTS:Early warning signals that of precaution effect were available through prescription-event monitoring on primary safeguarded newly marketed drugs.CON?CLUSION:Voluntary ADR reporting system is now prevalent in China,the prescription-event monitoring system assumed by England set a good example for us to follow.

Objective To assess the clinical diagnosis value of CT guided transthoracic core needle biopsy in patients with pathological changes.Methods The pathological diagnosis was performed after getting the tissue by the groovy needle punctured the lesion.Results The 165 patients included 153 focal pulmonary diseases and 12 diffuse pulmonary diseases,the defined pathological diagnostic rate was 92.1%,false negative rate was 3.9%,18.9%in malignant and benign pathological changes;and complication presented in 33.3%,pneumothorax,bleeding,hemoptysis and hypodermic haematoma were 17.0%,7.9%,7.3%and 1.2%,respectively.Conclusion The technique of pulmonary percutaneous biopsy under CT guided is a perfect method for qualitative diagnosis of difficult pulmonary pathological changes:it is of great clinical application.

Objective To investigate the characterized imaging in conventional MRI, get information about the metabolites in basal ganglia from proton MR Spectroscopy(~1H-MRS) of acute bilirubin encephalopathy(ABE) and find out the relationship between those changes and bilirubin levels. Methods Twenty-eight patients with acute bilirubin encephalopathy and 15 normal neonates underwent MR and ~1H-MRS examinations T_1 WI, T_2WI and DWI were collected via conventional MRI scanning of all neonates. All patients underwent multi-voxels scanning and 15 of them had single voxel scanning. ~1H-MRS used point resolved spectroscopy (PRESS) both in multi-voxels and single voxel scanning. The data of them were acquired from the ROIs placed in basal ganglia and globus pallidus, respectively. The metabolites including NAA choline, Lactate, glutamate and glutamine, myoinositol and creatine were quantitatively analyzed to compare them between the control group and the case group. Equality of variance between patient data and normal values were tested by using the two-tailed t test. The case group was divided into three groups of 342.0 μmol/L < TSB ≤ 427. 5 μmol/L,427.5 μmol/L < TSB ≤ 513.0 μmol/L, TSB > 513.0 μmol/L including 8,9,11 patients, respectively. Analysis of variance was used for statistics. Results Conventional magnetic resonance imaging showed symmetrical high signal of T_1WI in globus pallidus of 23 patients. The case group and the control group were significantly different. Single voxel ~1H-MRS revealed that the relative concentrations of Glx/Gr and mI/Cr in the control group were 0.95±0.23, 0.57±0.20, respectively, While those in case group were 1.45±0.37, 0.74±0.23, respectively. There were significant differences between two groups (t =2. 13,4. 40,P =0.04,0.00 respectively). Multi-voxels scanning 1H-MRS revealed that Glx / Cr were 0.51±0.36 in case group and 0.29±0.18 in control group. There was also a significant difference between two groups (t =2.17,P =0.03). And the values of Cho/Cr, NAA/Cr and Lac/Cr were not significantly different. The results were same in multi-voxels ~1H-MRS. Total bilirubin level and the concentration of metabolites in the brain do not have obvious correlation. Conclusions ABE has a characteristic signature which is symmetrical high signal of T_1 WI in globus pallidus on conventional MBI; The values of mI/Cr and Glx/Cr remarkably increase as detected by ~1H-MRS, which is generally in agreement with what has been known about bilirubin pathology.