Objective Bio-ceramics has been widely utilized as a common type of bone repair material.The research was designed to focus on preparation and characterization of porous TCP.Methods By using hydroxyapatite (HA) as the raw materials,and adding calcium phosphate bio-glass to adjust the ratio between calcium and phosphate,in order to achieve making porous TCP bio-ceramic scaffolds during high temperature heating process.Results Test results showed that by applying this method,TCP scaffolds had significantly higher mechanical strength then those were made from powdered TCP,and its compressive strength reached 9.11 MPa.Conclusion Tri-Calcium Phosphate (TCP) has excellent biocompatibility and it is also biodegradable.In the physiological environment,it is able to be gradually decomposed,absorbed and to promote bone growth ultimately,it is capable of replacing the damaged bone components with brand new bone tissues.

Objective:To explore therapeutic effect of rehabilitation intervention on aged patients with vascular de‐mentia (VD) .Methods :A total of 108 aged VD patients hospitalized in our hospital from Jan 2011 to Oct 2013 were selected .According to random number table ,they were randomly and equally divided into routine treatment group (received routine drug therapy and nursing ) and rehabilitation intervention group [received rehabilitation interven‐tion based on routine treatment group ,including trainings of computing ability ,thinking ability ,memory and activi‐ty of daily life (ADL) ability etc .] .ADL ability score ,mini-mental state examination (MMSE) score ,Wechsler memory scale (WMS) score were assessed ,compared and analyzed between two groups before and one year after in‐tervention .Results:There were no significant difference in ADL ,MMSE and WMS scores before intervention be‐tween two groups (P>0.05) .Compared with before intervention after one -year intervention ,there were signifi‐cant rise in ADL ability score [ (36.87 ± 9.09) scores vs .(47.54 ± 9.72) scores] ,MMSE score [ (16.87 ± 3.55) scores vs .(22.25 ± 3.41) scores] and WMS score [(59.14 ± 6.84) scores vs .(62.88 ± 6.59) scores] in rehabilitation intervention group ( P<0.05 all) ,and they were significantly higher than those of routine treatment group [ADL score :(38.31 ± 8.95) scores ,MMSR score :(16.72 ± 4.25) scores ,WMS score :(59.25 ± 6.11) scores] ,P<0.05 all .Conclusion:Rehabilitation intervention can improve cognitive function and memory and improve self -care a‐bility and quality of life in aged VD patients ,so its therapeutic effect is significant .

Extra-cellular signals, including T lymphoc ytes, cytokines,growth factors,interferons and neuropeptides, which could modulate matrix metalloproteinases expression in synoviocytes of rheumatoid arthritis(RA), are often mediated by G-protein-coupled Receptors (GPCR)-initiated signaling and mitogen-activated protein kinase (MAPK) cascades. Drug targets which aim at the extra-cellular signals or intra-cellular cascades is required for ameliorating inflammatory reaction and preventing joint destruction in RA.

Objective To understand the clinical characteristics of lower respiratory tract infection,pathogenic distribution and drug resistance in intensive care unit to provide a basis for reasonable use of antibiotics. Methods From January 2008 to August 2010,the clinical data from our hospital ICU impatients of lower respiratory tract infection were retrospectively analyzed. The isolated strains were identified, the antibiotic susceptibility test was performed by K-B methods and the results were read according to CLSI 2007. Results There were 509 patients, 147 cases of lower respiratory tract infection were found. Lower respiratory tract infection rate was 28.9% (147/509); 283 strains of pathogens had been isolated by culture and most of which were Gram negative bacilli(86. 9%), the other pathogens included Gram positive cocci(7.4%) and fungi(5.7%). The most common pathogens were Acinetobacter spp, Pseudomonas aeruginosa, Klebsiella pneumoniae,Stenotrophomonas oligotrophic aeromons, Fungi, Escherichia coli, Staphylococcus aureus, Burkholderia cepacia,etc,accounting for 24. 7% ,20. 5% ,12. 7% ,6. 4% ,5.7% ,5. 3% ,5.3% and 4. 6% ;The main pathogens were highly resistant to the most antibiotics. Conclusion ICU had a higher lower respiratory tract infection rate, Gram negative bacilli are the main pathogen, and showed the multi-drug resistance features to the antibiotics.

Objective To explore the curative effect of the single pore video-assisted thoracoscopic surgery and thoracic closed drainage for patients with acute pyothorax by comparing the advantage and disadvantage of two methods.Methods The clinical data of 65 patients with acute pyothorax in our hospital from January 2012 to June 2015 were retrospectively analyzed.Of which 30 patients underwent single pore video-assisted thoracoscopic surgery were as observation group,35 cases received thoracic closed drainage were as the control group.The cura-tive effect of two methods for acute pyothorax was compared by analyzing the result data of two groups.Results The postoperative chest tube indwelling time,length of hospital stay,postoperative antibiotics of observation group were significantly less than those of the control group,the difference was statistically significant(P<0.05).And the incidence of postoperative complications,the proportion of the chronic pyothorax and secondary tube rate of observation group were lower than those of the control group,the difference was statistically significant(P<0.05). Conclusion The single pore video-assisted thoracoscopic surgery is safe and effective for treatment of acute pyothorax, which is worth promoting.

The harm of tobacco is one of the most serious public health issues nowadays, and the social cost produced by smoking is increasing year by year. There are about 6 million people dying from smoking-related diseases each year, and the number of death will surpass 8 million by 2030. Helping smokers quit is the most direct and effective method to reduce the burden of disease caused by tobacco. M-health based on smartphone shows huge potential in prompting health behavior. Progress of studies on smartphone applications (APP), a new way of tobacco control, is reviewed to provide reference for future tobacco control practice and exploration.

Since the development of molecular biology,the treatment of advanced non-small cell cancer is shifting from traditional chemotherapy into molecular targeted therapy with genotyping as a guide′s help.The most widely used is epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs).With the appli-cation of EGFR-TKIs,the resistances to EGFR inhibitors are paid more and more attention,in recent years. The main mechanisms of acquired resistances are as follows:secondary mutation of the EGFR gene,amplifica-tion of c-MET,Her2 and other target genes,histological transformation,activation of the bypass mechanisms, loss of p53,the relief of negative feedback loops,overlap of mechanisms,etc.

The establishment animal model of Graves’ disease contributes to the study of etiology, pathogenesis and therapeutic modalities. After decades of studies and making improvements, the method of building mice model of Graves’disease has achieved a great development. Although there were many reports of animal model building in Graves’disease, as a mature technology A-subunit of thyrotropin receptor( TSHR)-expressing adenovirus was used to establish Graves’disease mice model, which has been accepted widely because of its high efficacy.

Objective To investigate the treatment of moed high anal fistula operation.Methods 110 cases of high anal fistula patients were randomly divided into the incision line selective suture group(treatment group 55 cases) and incision group(55 cases in the control group),on two groups of treatment time,the cure rate,the anal function were analyzed.Results The cure rate of the treatment group and control group were 98 ％,86％,respectively,the cure rates of two groups have no significant difference (x2 =1.557,P ＞ 0.05),the healing time and postoperative anal function evaluation in treatment group was superior than those in control group (t =3.440,4.671,all P ＜ 0.01).Conclusion Incisionunder selective suture in the treatment of high anal fistula operation is a better way.

Objective To observe and evaluate the efficacy of the preventing antibiotic-associated diarrhea in infant with bacterial pneumonia using the live Clostridium butyricum and Bifidobacterium combined Powders. Methods 103 infants with bacterial pneumonia were randomly divided into the two groups,53 infants as the trial group,another 50 infants as the control group with normal antibacterial therapy,two or three hours afterword the live Clostridium butyricum and Bifidobacterium combined Powders was administered at dose of 0.5g ti-daily in the trial group,After diarrhea taken place,the live Clostridium butyricum and Bifidobacterium combined Powders was adminis-tered at dose of 0.5g ti-daily in the control group,to contrast the rate of secondary diarrhea and clinical efficacy in the two groups.Results The incidence of antibiotic-associated diarrhea was 13.2%( 7/53 ) in the trial group and 56.0%(28/50) in the control group (χ2 =21.00,P<0.01).There were significant differences between the two groups.Duration of diarrhea and period of treatment in the trial group was obviously shorter than that of the control group,the rate of dehydration in the trial group was lighter than that in the control group(χ2 =6.64,P<0.01). Conclusion The live Clostridium butyricum and Bifidobacterium combined powders with antibacterial therapy at reg-ular intervals can prevent antibiotic-associated diarrhea.It is worthy of preventive application.