The high mobility group A2 (HMGA2) is a non-histone chromatin protein. It has no transcriptional activity of itself but could alter chromatin structure to regulate the transcription of other genes. HMGA2 gene is weakly expressed or does not express in normal tissues. The expression of HMGA2 is up-regulated during embryogenesis and malignant neoplasias. In several malignant tumors, HMGA2 is used as a diagnostic molecular marker or an independent prognostic indicator. Furthermore, HMGA2 not only elicits epithelial-mesenchymal transition but also maintains the differentiation potential and self-regeneration capability of stem cells. It plays an important role in initiation, proliferation, and metastasis of malignant neoplasias.

ObjectiveTo investigate the clinical efficacies of ultramicro needle knife plus Maitland technique in treating knee osteoarthritis.MethodEighty patients were randomly allocated to observation and control groups, 40 cases each. The observation group received ultramicro needle knifeplus Maitland technique and the control group, Maitland technique alone. The subjects’ symptoms were scored using the Visual Analogue Scale (VAS) and the Lysholm Knee Score Scale (LKSS) before and after four and six weeks of treatment. The clinical therapeutic effects were evaluated in the two groups.ResultAfter four weeks of treatment, the total efficacy rate was 91.9% in the observation group (37patients) and 76.3% in the control group (38 patients); there was a statistically significant difference between the two groups (P<0.01). The VAS score and the LKSS score improved significantly in the two groups compared with before treatment (P<0.01) and improved more in the observation group than in the control group (P<0.01). There were no statistically significant differences in the VAS score and the LKSS score between after six and four weeks of treatment in the observation group (P>0.05). There were statistically significant differences in the VAS score and the LKSS score between after six and four weeks oftreatment in the control group (P<0.05). No adverse reactions occurred during the whole treatment course.ConclusionUltramicro needle knife plus Maitland technique is significantly superior to Maitland technique alone and can markedly relieve the pain and dysfunction in patients with knee osteoarthritis. It is characterized by short time to produce an effect, a lasting therapeutic effect and high safety.

The hospital culture constrction should stick to a human-orientedconcept ,and aim to provide humanitarian brand services.Hospitals should create a favorable hospitalizing condition,and foster a standard treatment,which embodies the feathers of the present time while bearing its own characteristics .It should focus on the in-depth cultural constrction and try to carry out cultural management of the hospital,the leaders of the hospital play a critical role in the cultural constrction

The study was undertaken to determine whether low dose of endotoxin could induce rat brain damage, and its relation to the metabolism of oxygen free radicals. Male Wistar rats were treated with E. Coli endotoxin intraperitoneally (2 mg/kg body wt). Fourteen hours later, the lipoperoxide level was markedly elevated in animals given endotoxin compared with that in the controls (5.0?1.0 vs 3.9?0.7, P

ObjectiveTo study the validation of rehabilitation for deaf children with multichannel cochlear implant and to explore the relationship between the age and the rehabilitation effectiveness, and the change of the effectiveness over time.Methods24 prelingually deafened children with multichannel cochlear implant were investigated. And they were divided into two groups (more than 3 years old and less than 3 yeas old). The validation of rehabilitation was assessed in different times before the operation, 3 months, 6 months, 9 months, 12 months after the operation.ResultsThe longer the rehabilitation, the better the validation(P<0.05). The speed of the first group (more than 3 yeas old) is slower than the other group by the time(P<0.05).ConclusionDeaf children with cochlear implant may take more rehabilitation training after the operation.

Ricin is a plant-derived ribosome-inhibitor which can be easily purified in large quantities from castor beans. It is a potent irreversible inhibitor of protein synthesis. The mode of intoxication could be inhalation, ingestion, intravenous injection.Ricin has been classified as a schedule 1 threat agent by the Chemical Weapons Convention.A fast and sensitive method for the detection of this threat agent is an important tool for preventing or dealing with the consequences of intoxication. An ideal method should be highly sensitve, highly selective, and well capable of identifying ricin in a short assay time. Several methods have been established for ricin detection. This review summaries the development of detection methods for ricin in recent years.

We reported a case of nasal malignant granular cell tumor. The patient was a 51 years old man who went to the hospital because of "right nasal intermittent bleeding for half a year". The pathological examination after resection showed malignant granular cell tumor. No recurrence was noted during a year after resection. The etiology and pathogenesis, clinical features, pathological features and treatments of malignant granular cell tumor were reviewed.
Epistaxis ; Granular Cell Tumor ; pathology ; surgery ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Nose ; Nose Neoplasms ; pathology ; surgery

Objective:To explore the influence of radiofrequency ablation (RFA)on P-wave dispersion (difference between maximum and minimum P-wave interval)in patients with paroxysmal atrial fibrillation (PAF).Methods:A total of 95 PAF patients underwent circumferential pulmonary vein isolation.The preoperative and postoperative 12-lead ECG were recorded for 24h,maximum P-wave interval (Pmax)and minimum P-wave interval (Pmin)were measured,and P-wave dispersion was calculated.Since three months after operation,patients received outpatient follow up and dynamic ECG every month for six months.The operation was judged for successful or not according to symptoms of atrial fibrillation and dynamic ECG results,and patients were divided into success group (n=70)and recurrence group (n=25).Results:Compared with before operation,there was significant reduction in P-wave dis-persion [(48.84±4.08)ms vs.(42.22±4.02)ms,P <0.01]in all PAF patients after RFA.Compared with be-fore operation,there was significant reduction in P-wave dispersion [(47.63±3.58)ms vs.(40.67±4.82)ms,P<0.01]in success group;and reduction in P-wave dispersion [(49.51±1.64)ms vs.(48.26±3.48)ms]in recur-rence group,but no significant difference (P =0.346).After circumferential pulmonary vein isolation,P-wave dis-persion in success group was significantly lower than that of recurrence group (P <0.01).Conclusion:Circumferen-tial pulmonary vein ablation can improve P-wave dispersion in patients with atrial fibrillation,and it's more signifi-cant for success group.P-wave dispersion can predict the recurrence of atrial fibrillation after circumferential pulmo-nary vein ablation.

0.05). The rate of antibody elimination [70.83% (17/24)]was significantly higher than that of control group [29.17%(7/24 ) ( P

Objective To investigate the pathogenesis of endometriosis by studying endometriosis coexisting with variable genital tract anomalies and analysis the association between obstructive or nonobstructive anomalies with endometriosis.Methods From January 2000 to April 2010,a total of 67 cases of endometriosis coexisting with genital tract anomalies undergoing treatment in Peking Union Medical College Hospital were studied retrospectively.Results According to subtypes of concurrent genital tract anomalies,67 cases were divided into 19 cases in obstructive group and 48 cases in non-obstructive group.(1) Age and symptoms:the mean age were (22 ± 8) years in obstructive group and (32 ± 7) years in non-obstructive group,which reached statistical difference (P ＜ 0.05).The major symptoms were dysmenorrheal or chronic pelvic pain (14/19) and amenorrhea (8/19) in obstructive group.However,in non-obstructive group,the major symptoms were dysmenorrheal or chronic pelvic pain (31％,15/48) and infertility (35％,17/48) and abortion (21％,10/48).(2) Degree and incidence of endometriosis:the moderate or severe endometriosis was 11/19 in obstructive group and 40％ (19/48) in non-obstructive group,which did not show statistical difference (P ＞ 0.05).The incidence of peritoneal endometriosis,ovarian endometriosis,adenomyosis did not show significant difference between two groups (all P ＞ 0.05).The rate of moderate or severe endometriosis coexisting with duplex uterus,uterus bicornis and uterus septus did not show significant difference in non-obstructive group (P ＞ 0.05).Conclusions The severity of endometriosis showed no association with obstructive anomalies.The results implied that there might be other factors involved in pathogenesis of endometriosis.