Objective:To verify the applicability of Dynamic Contrast Enhanced Magnetic Resonance Imaging(DCE-MRI)to evaluate the breast cancer therapy using the high intensity focused uhrasound(HIFU).Methods:Both DCE-MRI and conventional T_1W/T_2W images were acquired for the total 8 subjects.Two consecutive scans were performed for every patient(before operation and 2 weeks after operation)while four were performed for only 2 patients(additional for 6 months and 12 months after operation).The breast cancer therapy by HIFU was assessed hy comparing the changes of signal,the dynamic patterns of time-signal intensity curve,the early-phase contrast enhancement ratios and vessel anatomies around cancer focuses.Results: The shortened T_2 signals were observed in cancer focuses of 5 subjects while 3 still showed longer T_2 values which were differentiated by the high intensity in T_2W images.The early-phase contrast enhancement ratios of those 5 subjects decreased from 60%～80% to

Objective To explore the risk management factors and preventive measures in obstetric care. Methods The implementation of risk management in our hospital was retrospectively analyzed. Results Maternal satisfaction degree was significantly increased, complaints and errors of nursing care were significantly decreased. Conclusions Strengthening of risk management in obstetric care can benefit to eliminate and prevent unsafe factors, so that obstetric care quality is improved.

Objective To identify the relationship among chronic inflammatory state, malnutrition and cardiovascular diseases in peritoneal dialysis patients. Methods Cardiovascular diseases and dialysis regime in 90 clinically stable continuous ambulatory peritoneal dialysis (CAPD) patients were investigated. Then, dietary energy intake (DEI) and protein intake (DPI) through dietary diaries were measured. The serum albumin (Alb), prealbumin(PA), transferring (TF), lean body mass (LBM), LBM% and the normalized protein equivalent of total nitrogen appearance (nPNA) were examined or calculated. Subjective global assessment (SGA) was also evaluated. Serum interleukin-6 (IL-6), tumor necrotic factor-?(TNF-?) and C-reactive protein (CRP) were measured as markers of chronic inflammation. Serum leptin and plasma NPY were detected too. Results Serum IL-6 and TNF-? levels of CAPD cases were (17. 17?27.72) pg/ml and (34. 21?25. 92) pg/ml, which were significantly higher as compared to control group. Serum CRP level in CAPD patients was (9. 88?20. 93)mg/L. There were 24 patients(26. 67% ) with CRP above normal level. 55 patients(61. 11% ) had cardiovascular diseases. The patients with angina pectoris, old myocardial infarction and chronic heart failure had higher CRP levels than those without above complications ( P

Objective To acknowledge the psychological authority status under the foundation of autho0rization management,in order to analyze the effectiveness of authorization management.Methods 364 clinical nurses were investigated with Psychological Empowerment Scale and the results were performed statistic analysis through descriptive statistical method and variance analysis.Results The average score of clinical nurses was(3.22±0.70),which was at the moderate point.The four dimensional scores listed in descending order were self efficient,career significance,autonomy and job influence.Clinical nurses of different ages,different ranking,different working period,different marriage status had statistical outstanding variance.But nurses of different education background showed no significant difference in score of each dimension.Conclusions The nursing management shall not only focus on the authorization management itself,but also on the psychological authority status of clinical nurses.Through an efficacious incentive,we can enhance the psychological recognition and experience on authorization and activate the working motivation,maximize the working initiative and thus promote the innovation and expansion of nursing work.

Objective To study the effect of letrozole plus metformin on infertility of polycystic ovary syndrome(PCOS).Methods According to the digital table,90 patients with infertility of PCOS were randomly divided into the control group(n =45 cases) and the treatment group(n =45 cases).The patients of the control group were treated though clomiphene,while the patients of the treatment group were treated though letrozole plus metformin.The ovulation rate,pregnancy rate,sex hormones and insulin resistance were detected.Results The homeostasis model assessment of insulin resistance index (HOMA-IR) was (5.72 ± 2.37) before treatment and (3.16 ± 1.39) after treatment in the treatment group.HOMA-IR was (5.69 ± 2.40) before treatment and (4.81 ± 2.06) after treatment in the control group.There was a significantly decrease in the treatment group (t =3.7246,P ＜ 0.05).The ovulation rate was 80％ in the treatment group,while 60％ in the control group,the difference between the two groups was significant(x2 =4.06,P ＜0.05).The pregnancy rate was 48.9％ in the treatment group,while 28.9％ in the control group,the difference between the two groups was significant (x2 =5.77,P ＜ 0.05).Conclusion Letrozole plus metformin could promote the ovulation and decrease insulin resistance.

Objective To detect the expression of the vascular endothelial growth factor (VEGF) and its receptors, the fms like tyrosine (flt 1), kinase insert domain containing receptor (KDR) in normal human endometrium during menstrual cycle and investigate the functions of VEGF and its receptors for development and differentiation of human endometrium Methods Immunohistochemistry and in situ hybridization techniques were used to measure the level of VEGF, flt 1 and KDR protein and mRNA in normal endometrium from 50 women Few samples of endometrium respectively in the proliferative and secretory phase were homogenized for Western Blot analysis of VEGF subtypes The blood vessel density was estimated by counting staining with a endothelial marker Ⅷ factor Results The VEGF and its receptors mainly expressed in endometrial endothelial cells and gland epithelium The level of VEGF, protein and mRNA, as well as flt 1 in mid secretory and menstrual phase were highest ( P 0 05) Western Blot analysis showed stained VEGF bands in 34 000 (VEGF 121 ), 46 000 (VEGF 165 ), 54 000 (VEGF 189 ), 68 000 (VEGF 206 ), predominantly in 34 000 and 46 000 Conclusions VEGF, flt 1 and KDR, including both protein and mRNA, showed a pronounced menstrual cycle dependent expression in cycling endometrium VEGF and its receptors expressing higher in secretory phase and menstruation probably be involved in embryonic implantation and endometrial shedding

Objective To study the relationship between neural apoptosis and the expression of Bcl-2,Bax proteins in the perihematomal brain tissue of patients with intracerebral hemorrhage(ICH).Methods The rate of neural apoptosis of perihematomal brain tissue was examined by TUNEL method and the Bcl-2,Bax proteins expression were detected by immunohistochemisty method. Correlation analysis was done not only for the expression of Bcl-2,Bax proteins and apoptosis rate with hematoma volume but also for the apoptosis rate with hematoma volume, the scores of clinical nervous impairment and the course of disease.Results The apoptosis rate and the expression of Bcl-2,Bax proteins in the perihematomal brain tissue of ICH patients significantly increased in comparison with the control group (all P

Attention is being paid to the treatment of hyperopia(presbyopia) with laser thermokeratoplasty.This article mainly presents the theory of laser thermokeratoplasty(LTK),equipment configuration and some key techniques in laser delivery system.

Through analyzing the ethical status quo in reproductive medicine treatment unit, this article dis-cussed the social ethical issues brought by ART technology development related to the reproductive medical treat-ment unit. Then it put forward the measures to solve those ethical problems: strengthening the ethical principles and ethical committee construction, sharing data information, fully informed consent, and suggestions to improving ethics education.

Microscopic polyangiitis (MPA) is an anti-neutrophil cytoplasmic antibody (ANCA) associated systemic small vessel vasculitis and is uncommon in children.Pathologically characterized by paucity immune deposition,fibroid necrosis and crescent formation in glomeruli.MPA is a multi-organ involvement disease.Renal is the mostly involved and commonly manifested as aggressive glomerulonephritis.Lung is the most common involved extrarenal organ.Most MPA patients have positive myeloperoxidase-ANCA and positive perinuclear-ANCA.The onset of MPA is usually obscure,which makes early diagnosis difficult.Detection of ANCA is performed in order to discriminate suspected MPA patients earlier.Confirmed diagnosis relies on pathology.Early standardized treatment is a key factor in prognosis.Standard inductive treatment is currently the combination of corticosteroids with the cytotoxic agent cyclophosphamide.Azathioprine is suggested as the first-choice medication in maintenance therapy.Bio-agents,such as Rituximab,have shown good curative effect both in the inductive treatment and maintenance therapy.