Matrix metalloproteinase (MMP)-9 is closely correlated with the pathophysiological processes of cerebral edema,inflammatory reaction and apoptosis after intracerebral hemorrhage.As a specific brain-derived protein,the different levels of S100B may present different physiological and pathological effects.Its concentration can reflect the degree of central nervous system damage.This article reviews the action mechanisms of MMP-9 and S100B in intracerebrai hemorrhage.

Objective To determine the influence of Fe2O3 coloring method to the mechanical and transparency parameter of dental zirconia.Methods Presintered zirconia blocks were coverd with zirconia powder blended with different ratio of Fe2O3,then sintered to 1450℃.Mechanical property and transparency parameter were calculated.Results The L* value was in the range from 64.91 to 90.94.The a* value was in the range from 1.27 to 12.70.The b* value was in the range from 1.02 to 38.66.There was no significant difference (P ＞ 0.05) of the flexural strength and in each group with the increase of Fe2O3.Conclusion This method produced dental zirconia specimens with light yellow to amber brown colors with the increase of Fe2O3 and no significant influence of mechanical property and transparency.

In-stent restenosis after interventional treatment remains an unsolved and important clinical problem. The proliferation and migration of arterial smooth muscle cells are key events frequently followed by vascular restenosis after angioplasty and continuous inflammation may also be the other important factor for the restenosis after stenting. Study of the pathogenesis of restenosis may find some potentially novel therapeutic pathways for attenuating in-stent restenosis.

Objective To study the effect of eicetaxin combined with psychological intervention on early cognitive function in the patients with hip arthroplasty.Methods From January 2015 to December 2016 in our hospital, 80 cases with hip arthroplasty were selected as the research object, which were divided into two groups (the control group and the observation group) according to intervention methods, 40 cases in each groups.The control group were given dicetaxin, the observation group were received dicetaxin combined with psychological intervention.The clinical data in the two groups were compared.Results After intervention, the cognitive function in the observation group was better than that in the control group;the clinical intervention effect in the observation group (95.0%) was better than that in the control group (72.5%);The incidence of adverse reactions (7.5%) in the observation group is lower than that in the control group (40.0%).The difference of the above data in the two groups was statistically significant(P< 0.05).Conclusion The clinical effect is significant that dezocine combined with psychological intervention were used on patients with hip arthroplasty, which can improve the early cognitive function in the patients, is worthy of clinical application.

This paper discusses the brachytherapy with tumour interventional radiology technology.The structure and security of the intravascular iridium-192 sources afterloader are reviewed in comparison with general afterloader.

Objective · To explore the clinical application value of hysteroscopic transcervical resection of endometrium (TCRE) combined with levonorgestrel-releasing intrauterine system (Mirena) in the treatment of adenomyosis. Methods · A total of 112 cases of adenomyosis patients were divided randomly into the combination group and Mirena group. The combination group (56 cases) was treated by TCRE endometrium endometrial resection, assisted Mirena treatment after operation. Mirena group (56 cases) was treated by Mirena only. The follow-up lasted 36 months after treatment, including measures of the volumes of menstrual bleeding, hemoglobin levels, dysmenorrhea scores, uterine volume, serum CA125 levels and incidences of complications.Results · The median follow-up duration was 42 months, and the three-year follow-up rate was 73.21% for the combination group and 50% for the Mirena group. After surgery, the volumes of menstrual bleeding of patients in 3-36 months decreased significantly, with an increase in hemoglobin level and a decrease in serum CA215 level and dysmenorrhea scores. Compared with their situations before surgery, the difference was significant (P<0.05). A comparison of uterine volume before and after surgery showed that there is a significant decrease in the uterine volume in both groups in6-12 months after surgery (P<0.05).Twenty-four months after surgery, it shows thatthe combination group has a much more significant decrease in uterine volume [(171.3±34.8) mm3] than Mirena group [(213.7±38.6) mm3] (P<0.05). The hysterectomy rate in Mirena group was significantly higher than that in the combination group (12.50% vs 5.36%); the ring expulsion rate was 16.07% in Mirena group and 5.36% in the combination group, and the break through bleeding happeningrate was 8.93% in Mirena group and 3.57% in the combination group. After 36 months an irregular small amount of vaginal bleeding rate was 62.25% in Mirena group, while it was only 12.50% in the combination group. There was significant differencewhen comparing above indices between two groups (P<0.05). There was no obvious differences in most common side effects of both groups. Conclusion · HysteroscopicTCRE combined with Mirena reduces significantly the irregular menstrual bleeding caused by merely applying Mirena. It has a prominent clinical efficacy and can be an effective approach in treatment of adenomyosis.

Objective:To study the relationship between graduate students'personalities, life events and psychic symptom.Methods:828 graduate students in Tianjin were investigated, their psychosomatic symptoms were rated with SCL-90 and psychosocial factors were assessed with Cattell 16 Personality Factors Questionnaire and Life Event Scale.Result:The first three factors in the psychosomatic symptoms were displayed in order: Obsession-compulsion(0.67?0.55), Interpersonal sensitivity (0.61?0.56), and Depression(0.50?0.51).The personalities were revealed as follows: E (6.23?1.69) , F(6.23?1.80) and Q 4(6.12?1.10), these factors were higher than Chinese norm, L (3.82?1.62), O (4.64?1.70) and I (4.86?1.62) were lower than norm.Conclusion:Male, having siblings, engineer and negative scores of work and study are risk factors for psychosomatic symptoms, whereas medical staff is a protective one.

OBJECTIVE: To study the feasibility and the generalizability of the Remote fitting models of hearing AIDS from primary hospitals. METHOD: we comparative analyzed the speech recognition scores and satisfaction of 45 cases with traditional hearing AID fitting and with a hearing aid remote test respectively. RESULT: 45 cases were analyzed in each group, including traditional hearing AID fitting model and remote test, and 35 recovered in traditional fitting model group, and the recovery rate was 77.8%; Remote fitting model rehabilitation 42 cases, recovery rate was 93.3%, the difference was statistically significant (P < 0.05). In 6 weekend wear hearing AIDS, traditional fitting model of speech recognition rate increased by 19.40% on average, the average distance fitting model speech recognition rate increases by 27.47%, the average distance fitting model than traditional fitting the speech recognition rate increased significantly more (8.07%). Effect of hearing aid international questionnaire results suggest: 45 cases using traditional model fitting hearing AIDS patients, 33 cases (73.3%) satisfaction, 12 cases (26.7%) patients after use. Remote and 45 cases of using hearing AIDS fitting model, satisfied with 40 cases (88.9%), 5 cases (11.1%) patients after use. CONCLUSION the curative effect and the satisfaction of remote fitting models of hearing AIDS on hearing impairment are better than that in patients with traditional fitting models. Therefore it is more worthy of clinical application especially in basic level hospitals.
Audiometry ; Hearing Aids ; Hearing Loss ; rehabilitation ; Hearing Tests ; Humans ; Patient Satisfaction ; Remote Consultation ; Speech Perception ; Surveys and Questionnaires

BACKGROUND:As a more common method in the orthopedic field, the method of intra-articular injection drugs has distinct curative effects, but there are some complications. In a certain extent, this method caters to the psychological fear of surgery, and can serve as a kind of conservative treatment. But some experts believed that because of the limit of sterile conditions, intra-articular injection of drugs wil increase the risk of intra-articular infection and they opposed this method.
OBJECTIVE:To review the efficacy and adverse reactions of intra-articular injection drugs in recent years, and explain clinical applications of intra-articular injection drugs in orthopedics.
METHODS:A computer-based search was conducted in PubMed and Wanfang database for articles related to the application of intra-articular injection drugs in orthopedics published between January 2007 and December 2013. The English and Chinese key words were“intra-articular, injection, orthopaedics, tranexamic acid, hyaluronic acid, corticosteroid, drugs”. Data were checked in the first trial, old articles and repetitive studies were excluded. The relevant 43 articles accorded with inclusion criteria were reviewed.
RESULTS AND CONCLUSION:In orthopedics, the method of intra-articular injection drugs is simple, economic and effective, but at the same time, there are some side effects. Tranexamic acid by intra-articular injection can significantly reduce blood loss after total joint replacement, is safety and economic. Intra-articular injection joint lubricant can reduce internal friction of joints and improve the adhesion of joint cavity, can be used as a good conservative treatment for osteoarthritis. Intra-articular injection hormone drugs can treat inflammatory arthritis, and short-term curative effect is obvious, but due to large long-term side effects, the method is not recommended now. Intra-articular injection of analgesic drugs and other drugs have both advantages complications. The efficacy of intra-articular injection drugs in orthopedics is obvious;meanwhile, this method has some complications. Orthopedic surgeons should select related drugs by indications. We stil need to further make reasonable regimen with intra-articular injection drugs in future large-scale study.

BACKGROUND:Tranexamic acid has been more and more used in reducing bleeding after joint replacement, but its usage method and dosage remain controversial, and become a hot focus in recent years. OBJECTIVE:To investigate the efficacy of intra-articular injection of tranexamic acid on postoperative blood loss and limb circumference changes in patients who received unilateral total knee arthroplasty. METHODS:From March to October 2013, clinical data of 90 patients undergoing primary unilateral total knee arthroplasty were randomized to the tranexamic acid group and the control group, including 19 males and 71 females. The 30 patients in the tranexamic acid group received 50 mL of 3%tranexamic acid dilute solution inside knee joint after capsule closure, and 60 patients in the control group received the same volume of physiological saline. No significant difference in age, height, body mass index, anticoagulation, the type of prosthesis, tourniquet time and preoperative diagnosis was detected between the two groups (P>0.05). The amounts of intraoperative and postoperative blood loss and blood transfusion, postoperative drainage volume, the preoperative and postoperative limb circumference 10 cm above the operated knee were recorded. Routine blood test was reviewed after the surgery. RESULTS AND CONCLUSION:There were no significant differences in total blood loss, postoperative drainage volume and limb circumference changes between tranexamic acid and control groups (P>0.05). The amount of postoperative hidden blood loss was significantly less in the tranexamic acid group than in the control group (t=-2.683, P<0.05). These data suggested that the intra-articular injection of tranexamic acid intraoperatively in patients receiving total knee arthroplasty could significantly reduce the amounts of postoperative hidden blood loss, and did not affect the postoperative limb circumference changes.