Peroxisome proliferator-activated receptors(PPAR) are ligand-activated nuclear transcription factors which regulate the expression of many genes.Numbers of researchs indicate PPAR exert anti-inflammatory activities by inhibiting the expression of inflammatory singal transcription passage such as NF-?B,AP-1,STAT,meanwhile preserve from acute lung injury.This review will focus on structure of PPAR and their ligand and activity regulation and antiinflammation mechanism of action and protection to acute lung injury.

There are about 170 kinds of medical plants of Commelina all over the world.Experimental studies showed that the main chemical compositions in the plants included alkaloids,flavonoids,terpenes,and sterols etc.Plants of commelina,especially commelina communis,have pharmacological activities of antibacterial,antiinflammation,resisting-oxidation,lowering-glycemia,relieving-pain and stopping-cough etc.It is necessary that their pharmacological effects and chemical compositions are further developed and investigated systematically.

On the one hand, diabetes mellitus and psychological diseases can affect each other to bring about many bad consequences, such as insomnia. On the other hand, insomnia can also cause diabetes mellitus and psychological diseases. TCM also has some knowledge on the relations between them. The present paper is a general survey of recent studies on this field in China and abroad.

Objective To observe the clinical effect of warming needle moxibustion and acupuncture therapy for knee osteoarthritis of deficiency cold type , and explore effective ways to treat knee osteoarthritis of deficiency cold type .Methods Eighty three patients with cold knee osteoarthritis in our hospital from May 2010 to April 2014 type were randomly divided into warming acupuncture group (42 ca-ses) and control group (41 cases).Patients in warming acupuncture group were given the treatment of warming needle moxibustion meth -od, and those in the control group were given the treatment of simple acupuncture .After three courses of treatment , the treatment effect and compliance of two groups during treatment was closely obserred .Results Efficiency of warming acupuncture group was 95.0%.It had significant difference compared with 85.7%in the control group (P<0.05).Treatment compliance rate of warming acupuncture was 95.2%, which was significantly higher than 85.4%of control group (P<0.05).At the end of each treatment period , Joint pain relief degree of warming acupuncture group patients were significantly higher than those in control group (P<0.05), and joint pain degree of warm acupuncture group reduced significantly after a course reduced compared with it before a course (P<0.05).Conclusion The cur-ative effect of warm acupuncture in the treatment on knee osteoarthritis of deficiency cold type is better than that of simple acupuncture therapy.It is worth in clinical application .

Objective:To investigate the clinical curative effect of focused ultrasound on vulval condyloma acuminatum.Methods:108 cases of vulval condyloma acuminatum confirmed by pathology were randomly divided into two groups with the same number in each group:ultrasound group and laser group(controls).54 cases in the ultrasound group were treated with focused ultrasound,other 54 cases underwent laser treatment.The symptoms and local changes of the patients were observed before and after the treatment.The warts were obtained for pathological analysis to evaluate the efficacy of focused ultrasound treatment.Results:1.In the ultrasound group,49 cases recovered after the first treatment,the efficacy rate was 90.7%(49/54),while in the laser group,the rate was 68.5%(37/54).There was significant difference between the two groups(P

Objective:To explore the effect of cholecystokinin on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius.Methods: The effects of gastric distention and intravenous CCK on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius were investigated in urethane anesthetized rats.Results:Intravenous CCK could obviously influence the spontaneous activity of gastric distention related neurons in the nucleus of tractus solitarius.Intravenous CCK could increase the discharge of gastric distention(GD)excited neurons(9/14)and decrease the discharge of GD inhibited neurons(5/14) in NTS.Howerer,the effect of CCK on gastric distention-induced discharge of GD related neurons was always inhibitory.Conclusion:Circulating CCK and gastric distention have both excitatory and inhibitory effects on the electricity activity of gastric distention related neurons in NTS,but the effect of CCK on gastric distention-induced discharge of GD related neurons is inhibitory.The effect of gastric distention on spantenous discharge of neurons in NTS is similar to circulating CCK.

Objective:To discuss the clinical value of pelvic devascularlization in prevention and treatment for gynaecology and obstetrics refractory hemorrhage.Methods:To analyze retrospectively the effect of 15 cases of obstetrics,2 cases of preventing hemorrhage,5 cases of gynaecology refractory hemorrhage,all of these are treated by pelvic devascularlization.Results:There are 2 cases of placenta praevia of central type,(hemostatic scrap interdict uterus artery blood flow,volume of hemorrhage

OBJECTIVE:To evaluate the economic effectiveness of different pharmacotherapeutic schemes for the same disease METHODS:Using retrospective study and pharmacoeconomical cost-effective analysis,five schemes for child virus pneumonia were compared RESULTS:There were no significant differences in efficacy among scheme A,B,C,D and E (X2=3 248,P=0 517) The costs of scheme A,B,C,D and E were 2 457 76,2 446 74,1 642 56,2 062 26 and 1 476 6 yuans and cost-effectiveness ratios obtained by sensitivity analysis were 26 08,30 58,17 67,26 16 and 19 61 respectively CONCLUSI_ON:Pharmacoeconomically,scheme C is the most effective,the safest and the most economical one among five schemes

Diffuse large B-cell lymphoma (DLBCL) has a high degree of heterogeneity in clinical manifestations,pathological morphology and genetic features.According to its classification by WHO in 2008 WHO,DLBCL is defined as large B-cell lymphoma with diffuse growth and having nuclei similar with or larger than those of normal macrophages.In recent years,the clinical features,morphology,immunohistochemistry,and even gene expression pattern are integrated for classification of DLBCL.It's a new era to stratify DLBLC by gene expression profile.This article summarized research progress in DLBCL classification based on gene expression profile and immunohistochemistry and its effects on prognosis of DLBCL.

Alport syndrome, characterized by hematuria, renal failure, sensorineural deafness, and ocular abnormalities, is an inherited glomerular disease caused by mutations in the COL4A5 (X-linked), or COL4A3 and COL4A4 (autosomal recessive) genes.The ultrastructural changes of Alport syndrome can be observed in the electron microscopic analysis of renal biopsies, which are characterized by irregular thinning/thickening, layering and splitting dense layer of the glomerular basement membrane.In the basement membrane of skin and renal biopsy tissue, type IV collagen α chain immunofluorescence test can be used to diagnose Alport syndrome, screen the carriers and determine the mode of inheritance.The analysis and detection of Alport syndrome gene are not only useful for genetic counseling, but also useful for identification of gene carriers, prenatal diagnosis, and identification of suspected patients who can not be confirmed by clinical and pathological examination results.