ObjectiveTo evaluate therapeutic effect and the possible mechanism of smecta on paraqual plasma concentrations and multiorgans injury induced by paraquat intoxication in rats. Methods A total of 76 healthy adult SD rats were randomly ( random number) divided into group A (control group n =6),group B ( poisoned group n =30 ),group C (smecta-treated group n=30).Rats in groups B and C were treated intragastrically with PQ at 50 mg/kg,the rats in the group C were given with smecta at 50 mg/kg,while the rats in the other two groups were only intragastrically adminstered with saline.Live rats in groups B and C were sacrificed at 2,6,24,48,72 h after administration of PQ for the determination of paraquat plasma concentrations and for HE staining of lung,stomach and jejunum.The rats were executed at the end of trial by the same way in group A.All measurement data were expressed as means + standard deviation ((x) ±s).The data of pathological score were compared with Independent-samples T test and the data of PQ concentration compared with analysis of variance (ANOVA) followed by LSD-t multiple comparison test.P-values of less than 0.05 were considered statistically significant.ResultsThe paraquat plasma concentration ( ng/ml ) was 440.314 ± 49.776 to 4320.6150 ± 413.947.There were different pathological changes of lung,stomach and jejunum in group B. Lung injuries gradually deteriorated,congestion,edema,leukocyte infiltration,incrassated septa and lung consolidation were observed.The pathological changes were obvious such as abruption of mucosa,hyperemic gastric mucosa and leukocyte infiltration in stomach.Haemorrhage of jejunum mucosa,abruption of villus,gland damage and inflammatory cell infiltration were found. Compared with group B,all the pathological changes mentioned above were obviously alleviated in group C ( P ＜ 0.05 ),and the concentrations reduced ( P ＜ 0.01 ).Conclusions Smecta reduced paraquat plasma concentrations and alleviated pathologic injury of rats with PQ poisoning.

Objective To observe the clinical effect of manipulation combined with physical therapy on middle-elderly knee osteoarthritis (KOA).Methods 32 KOA patients (49 knees) were treated with manual operation, such as manipulation relaxing the end of quadriceps, triceps, surae and other manipulation method for knee joint and combined with physical therapy.Results 11 cases (18 knees) were clinical curative, 16 cases (23 knees) had good effective, 5 cases (knees) had effective. The good effective rate was 84%.Conclusion Manipulation combined with physical therapy is effective on middl-elderly KOA patients.

Objective To observe the effect of manipulation treatment on headache induced by pure pillow linea nuchae inferior adhesion muscle spasm.Methods 36 headache patients caused by pure pillow linea nuchae inferior adhesion muscle spasm were treated by manipulate the methods of finger press and palm root circle press in base on fixing Ash points according to the symptoms and physical signs.Results After 5 to 10 times by manipulation,of 36 patients,25 cases were recovery,10 cases were excellent,1 case was effective,and the excellence effective rate was 97.22%.Conclusion The manipulation treatment is effect on headache induced by pure pillow linea nuchae inferior adhesion muscle spasm;the curative effect is satisfactory and stable.

Objective To explore the relationship between the somatosensory evoked potential (SEP) diversification during operation and the short term outcome of ossification of posterior longitudinal ligament (OPLL) of cervical spine. Methods 70 OPLL inpatients from February 2008 to February 2011were included in this study. All patients received anterior cervical operation. According to the diversification of the SEP during surgery, the patients were divided into 2 groups. The preoperative and postoperative JOA scores of the OPLL patients were collected. Results There were 35 patients in the SEP no change group and 30 in SEP improved group. There was no difference in the preoperative JOA scores between them (P>0.05), but was significantly different in the postoperative JOA scores (P>0.05). Conclusion There is some relationship between the SEP diversification during operation and the short term outcome of OPLL of cervical spine.

Objective To study the test-retest reliability of grip strength assessment in the bed-ridden elders above 80 years old. Methods The left and right grip strength of 20 patients who were bed-ridden for more than 1 year, older than 80 years were measured on the lying position with the JAMAR Hand Dynamometer, and they were measured again in the same way by the same conner a week later. Results The intraclass correlation coefficient were 0.985 and 0.970 in the grip strength of left and right hands, respectively. Conclusion The assessment of grip strength showed good test-retest reliability in the bed-ridden elders above 80.

ObjectiveTo explore the convenient and effective therapeutic methods for acute lumbar strain on the basis of classification and mechanism of acute lumbar strain.MethodsAcute lumbar strain was classified into post-lumbar joint disturbance type, post-lumbar joint embedded type, muscular strangulated type, muscular strain, sacroiliac joint malposition and mixed type.The repulsion reposition, orthodromic allocation, repulsion ilium and moving leg combioned with high electric frequence were chosen according to the patients' age and somatic condition.ResultsAfter 1-3 times curing, the symptom and appearance of the patients were obviously improved, even more recovery. In these 100 cases,52 patients were cured,39 patients were obviously improved, 9 patients were better than before, the rate of obvious effect was 91%.ConclusionsManipulation combined with high electrical frequence is a convenient, safe and effective method for acute lumbar strain.

ObjectiveTo investigate the relationship of lower extremity muscle strength and the pain or physical function in patients with knee osteoarthritis. Methods25 patients with knee osteoarthritis diagnosed with have radiological and clinical data were assessed with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and isokinetic muscle strength testing. ResultsThe lower extremity extensor muscle strength correlated with WOMAC pain scores, WOMAC activity of daily life scores, and WOMAC total scores （P<0.05）. ConclusionThe lower extremity extensor muscle strength correlated with the pain and physical function in patients with knee osteoarthritis.

ObjectiveTo determine the value of the five-times sit-to-stand test (FTSST) on assessment of physical performance for older people.Methods65 volunteers participated in this study. 21 of them were evaluated the FTSST twice by the same raters within one week. Test-retest reliability assessed using intraclass correlation coefficients (ICC). 65 volunteers were tested for the FTSST, the Timed "up & go" test(TUGT) and the strength of lower limbs. The Pearson's correlation (r) and stepwise regression analysis was used to examine the relationship between these variables and the FTSST time.ResultsThe FTSST showed good test-retest reliability(ICC=0-91, 95%CI:0-79～0-96). The TUGT, the strength of lower limbs and age were significantly related to the FTSST time (P<0-05). The strength of lower limbs was important clinical factor to consider in determining the FTSST time.ConclusionThe FTSST showed good test-retest reliability and can reflect the physical functional status of older people.

ObjectiveTo observe the effect of acupoint rotating magnetic field(RMF) therapy on the pain and Fricton's index in patients with temporomandibular disorders(TMD).Methods65 TMD patients, who met the inclusive criteria, were randomly divided into two groups: the acupoint rotating magnetic therapy group(treatment group, n=35) and the ultrashortwave diathermy group (control group, n=30). The treatment group received XZC-A rotating magnetic field therapy at the acupoints in the affected side, including Xiaguan(ST7), Tinggong(SI19), Jiache(ST6), Yifeng(SJ17) and Ashi, 10 minutes for each acupiont, the course of treatment was performed twice daily for 10 days. The control group was treated with ultrashortwave diathermy for 15～20 min once daily, and considered 10 days as a course of treatment. The patients were evaluated before and after the treatment through Visual Analogue Scale (VAS) and Fricton's Craniomandibular Index(CMI) respectively.ResultsThe values of VAS and CMI in the both groups significantly reduced after a course of treatment respectively (P<0-05), and there were significant differences regarding the post-therapy values of VAS and CMI (P<0-05) between two groups. The values of VAS and CMI in the treatment group reduced more significantly than those in the control group(P<0-05).ConclusionAcupoint rotating magnetic field therapy can relieve the pain and improve the functions of TMD in patients with temporomandibular joint disorder.

Objective To investigate the balance function of the knee osteoarthritis (KOA) patients and the clinical value about static fallindex test and dynamic fall index test for the patients with knee osteoarthritis. Methods The osteoarthritis patients without knee pain (controlgroup, n=30) were tested with postural stability (PS), limits of stability (LOS), dynamic fall index (DFI) and static fall index (SFI). Theosteoarthritis patients with knee pain (treatment group, n=30) accepted 10 times of diclofenac diethylamine emulge imported by pulsed ultrasoundand 6 times of massage therapy. They were also tested with above four balance tests and Western Ontario and McMaster UniversitiesOsteoarthritis Index (WOMAC) before and after treatments. Results There was significant difference in overall of PS, anterior/posterior indexand medial lateral index (P<0.05) between the control group and the treatment group before treatments, and there was very significantdifference in time to complete LOS, overall of LOS and DFI (P<0.01); but there was no significant difference in SFI (P<0.05). There wassignificant difference in WOMAC scores, overall of PS, anterior/posterior index, time to complete LOS, overall of LOS and DFI (P<0.05) inthe treatment group before and after treatments, but there was no significant difference in medial lateral index and SFI (P<0.05). ConclusionCompared with osteoarthritis patients without knee pain, KOA patients with knee pain are in poorer balance function and greater fall risk.After effective treatments, the balance function and fall risk of the KOA patients may significantly improve. Compared with SFI test, theDFI test is more sensitive to the improvement of balance function of the KOA patients.