1.Conservative Management of Calcaneal Fractures. A Retrospective Review of Treatment Outcome
Malaysian Orthopaedic Journal 2008;2(1):28-32
Int roduction: Treatment of calcaneal fracture is still
controversial and indication for surgery is not well
established. We are reporting the mid term outcome of
calcanel fractures treated conservatively.
Material and Methods: Patients admitted with calcaneal
fractures from 1st November 2002 till 31st December 2004
and were treated conservatively were included in this study.
The fractures were grouped according to Essex-Lopresti
classification and their outcomes were assessed with the
Maryland foot score. We also looked at time to weight
bearing and returning to occupational activity.
Results: Forty-four patients were included for evaluation.
Patients with extraarticular calcaneal fractures had
significantly higher rating scores compared to those with
intraarticular fractures (98.2 and 88.8 respectively, with a p value = 0.0001). Generally, both group of patients had a good clinical outcome. 18 of the 44 patients (41%) started partial weight bearing before or at 6 weeks and 31 patients (72%) were able to start full weight bearing by 12 weeks. 31 patients (72%) were back to work 12 weeks after the injury.
Conclusion: Conservative management for calcaneal
fractures is an acceptable mode of treatment with satisfactory functional outcome.
2.Pharmacognostic evaluation of Lens culinaris Medikus seeds
Vohra Kripi ; Gupta Kumar Vivek
Asian Pacific Journal of Tropical Biomedicine 2012;(z3):1221-1226
Objective: To present a detailed pharmacognostic study of the Lens culinaris Medikus (Fabaceae) seeds, a food grain used as Dhal in India. Methods: The macroscopy, microscopy, fluorescence analysis of powdered drug, physicochemical analysis, preliminary testing and other WHO recommended methods for standardization were investigated. Results: Seeds are greyish brown in colour. Treatment of powdered drug with various chemical reagents showed the presence of proteins, cellulose, lignins and fixed oils. Microscopy of seeds revealed the presence of starch grains in seed. The colour of seed coat changed from brown to greenish grey in day light and brown to black at 254nm when treated with acetic acid. Total ash value of the seeds was found to be 1.86% w/w whereas foreign organic matter was found to be nil. Qualitative phytochemical analysis revealed the presence of tannins and flavonoids in acetone extract. Conclusions: The present study on pharmacognostic profile of Lens culinaris Medikus seeds provides an important tool in identification and authentication of this plant to researchers in future.
3.Description of Risk Factors among Asthma Patients who were Intubated in CWM Hospital
Fiji Medical Journal 2018;24(1):29-35
Introduction:
Risk factors for life-threatening asthma resulting in intubation and ventilation are well documented in the international literature. Patients and health systems differ and it is not known whether such risk factors apply to the Fijian population. This study documents the prevalence of risk factors and describes the outcomes of patients who were intubated for severe asthma in Suva, Fiji.
Methods:
Retrospective descriptive study of patients intubated for asthma at the Colonial War Memorial Hospital between December 2012 and January 2014
Results:
There were 53 patients with 64 intensive care admission episodes. There were equal numbers of males and females. Regarding the risk factors identified from other studies, 75% of our study population reported increased beta agonist use and 32% reported increased inhaled steroid use. 68% had previous hospital admissions for asthma and 23% had been previously intubated. Twenty-one percent of the patients died during admission. Most deaths were due to hypoxic brain injury following cardio-respiratory arrest on presentation to hospital. At one year follow up, 15% of the discharged patients had died and 4 % had suffered another severe asthma attack resulting in intubation.
Conclusion
Internationally-reported risk factors were present in similar proportions in our study population. This suggests similar strategies should be employed to reduce morbidity and mortality from asthma in Fiji. These include: improving asthma education among patients and clinicians, increasing utilization of preventer medications, use of a spacer devices and asthma action plans.
4.Unlocked Nailing vs. Interlocking Nailing for Winquist Type I and II Femoral Isthmus Fractures. Is there a Difference?
CK Yu ; HY Wong ; AS Vivek ; BC Se To
Malaysian Orthopaedic Journal 2008;2(1):23-27
Interlocking intramedullary nailing is suitable for
comminuted femoral isthmus fractures, but for noncomminuted
fractures its benefit over unlocked nailing is
debatable. This study was undertaken to compare outcomes
of interlocking nailing versus unlocked intramedullary
nailing in such fractures. Ninety-three cases of noncomminuted femoral isthmus fractures (Winquist I and II)
treated with interlocking nailing and unlocked nailing from 1 June 2004 to 1 June 2005 were reviewed; radiological and clinical union rates, bony alignment, complication and knee function were investigated. There was no statistical significant difference with regard to union rate, implant failure, infection and fracture alignment in both study groups. Open fixation with unlocked femoral nailing is technically less demanding and requires less operating time; additionally, there is no exposure to radiation and cost of the
implant is cheaper. We therefore conclude that unlocked
nailing is still useful for the management of non-comminuted isthmus fractures of the femur.
5.Distal Radius Morphometry in the Malaysian Population
Chan CYW ; Vivek AS ; Leong WH ; Rukmanikanthan S
Malaysian Orthopaedic Journal 2008;2(2):27-30
The goal of treatment in distal radius fracture is to restore the anatomy of the distal radius, however the criteria currently used to evaluate the quality of reduction are based on Western based published figures. This goal of this study was to investigate whether there are variations in the morphology
of the distal radius among the multiracial population of
Malaysia. Consecutive normal wrist radiographs of patients
who presented to the accident and emergency unit in three
major hospitals in Malaysia were measured. . The palmar tilt of the distal radius averaged 12.6o ± 3.55o, and the radial inclination averaged 25.1o ± 3.42o. The ulnar variance averaged – 0.1 ± 1.31mm, 38.4% of the patients had neutral ulnar variance, 28.8% have negative ulnar variance and 32.9% have positive ulnar variance. Our results indicate that distal radius morphometric parameters in the Malaysian population are comparable to Western figures.
6.Cannulated Screw Fixation For Femoral Neck Fractures: A 5-year Experience In A Single Institution
Khoo CCH ; Amber Haseeb ; Vivek Ajit Singh
Malaysian Orthopaedic Journal 2014;8(2):14-21
Cannulated screw fixation is a widely accepted surgical
method for management of fractures of the neck of femur
especially in patients with poor premorbid conditions,
minimally displaced fractures and those from a younger
age group. A five year retrospective study was carried
out in 53 consecutive patients between 2006 to 2010 to
determine the pattern of injuries, management, outcomes
and the associated predictive factors.All the patients
underwent cannulated screw fixation, with 37 (69.8%)
having had surgery within 24 hours and the remaining
16 (30.2%) 24 hours after the initial injury. All patients
were followed up to union of fractures and complications
thereafter if any. Good outcome was observed in 43
(81.1%) patients leaving only 10 (18.9%) patients with a
poor outcome, of whom nine developed avascular necrosis
(90%) and one non-union (10%). We found no significant
relationship between the incidence of avascular necrosis
and age of patient, fracture displacement, numbers of
cannulated screws used, fracture reduction acceptability
and anatomical location of the fracture. The time interval
from injury to surgery and the presence of posterior
comminution did seem to influence the rate of avascular
necrosis but due to the small number of patients, was not
statistically significant.We conclude that cannulated screw
fixation is a viable option of treatment for fractures of the
neck of femur.
Femoral Neck Fractures
7.Bilateral Mirror Image Cervical Neurofibroma in an Adult with Neurofibromatosis Type 1
Sharad Pandey ; Kulwant Singh ; Vivek Sharma ; Mohammed Tabish Khan
Malaysian Journal of Medical Sciences 2017;24(1):117-120
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterised by
various phenotypic features like hyperpigmented spots, neurofibromas, Lisch nodules, skeletal
abnormalities and tendency to develop neoplasms. Only few cases of Non-Familial Spinal
Neurofibromatosis-1 (Non-FSNF1) have been described in literature with tumors involving
the spinal roots at every level being even rarer. We reported an interesting case of bilateral
symmetrical cervical neurofibroma with multiple spinal neurofibromas appearing as mirror
image on CT, associated with non familial NF-1 as a rare presentation in a 25-year-old adult male.
8.Awareness and Involvement of the Arts, Commerce and Science College Teachers in Students’ Mental Health and Behavioural Problems: A Cross-sectional Study from Sangli District (MH), India
Vivek Baliram Waghachavare ; Alka Dilip Gore ; Girish Bhimrao Dhumale
The International Medical Journal Malaysia 2017;16(1):37-44
Background: Teachers play an important role in reducing adolescent health problems. However, the
involvement of teachers in adolescent health is not well understood. This current study was conducted to
address this. Methods: A cross-sectional study was conducted among teachers of randomly selected arts,
commerce and science colleges in Sangli, (Maharashtra) India. The data was collected by cluster random
sampling. The study period was from November 2014 to April 2015. The study tool was self-administered
questionnaire. Due ethical considerations, consents were taken. Analysis was done using Microsoft Excel
2003 and IBM SPSS version 22. Results: Out of 319 study participants; 246 (77.1%) participants had good
awareness regarding adolescent health problems, 254 (79.6%) participants had good attitude towards
reproductive health. Forty-three (13.5%), 22 (6.9%) and 15 (4.7%) participants had good practices regarding
behavioural problems, psychological problems and substance abuse respectively. Practices about
behavioural problems and substance abuse were associated with adolescent health training. In bi-variate
analysis, age was a significant predictor for all the three practices. Conclusion: Most teachers had good
attitude and awareness; but poor knowledge and practices regarding adolescent issues. All teachers should
undergo training regarding adolescent health; with periodic refresher courses or lectures. Anonymous
feedback from students should be sought to keep vigilance over efforts of the teachers.
9.Ruptured Aortic Aneurysm Secondary to Psoas abscess after Intravesical Bacilli Calmette-Guérin
Ashish Khandelwal ; Ankur Gupta ; Vivek Virmani ; Kanika Khandelwal
The Medical Journal of Malaysia 2012;67(5):534-535
Bacillus Calmette-Guérin (BCG) is a live attenuated strain of Mycobacterium bovis that has been used as effective
treatment for early-stage transitional carcinoma of the
urinary bladder. We present a case of a 68 year old man who
had an abdominal aortic aneurysm following BCG therapy
for bladder cancer. Contrast enhanced computerized
tomogram (CECT) of abdomen and pelvis revealed bilateral
hypodense lesions suggestive of psoas abscesses. In
addition, a saccular abdominal aortic aneurysm measuring
4x3.6 cm involving infrarenal aorta with surrounding
hematoma was seen. At surgery, he was found to have a
psoas abscess and hemorrhage. He underwent ligation of
the aorta and an axillary-bifemoral bypass. He was given one year of anti-tubercular therapy to which he responded
clinically.
10.Therapeutic potential of snake venom in cancer therapy:current perspectives
Vyas Kumar Vivek ; Brahmbhatt Keyur ; Bhatt Hardik ; Parmar Utsav
Asian Pacific Journal of Tropical Biomedicine 2013;(2):156-162
Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer. Snake venom toxins contributed significantly to the treatment of many medical conditions. There are many published studies describing and elucidating the anti-cancer potential of snake venom. Cancer therapy is one of the main areas for the use of protein peptides and enzymes originating from animals of different species. Some of these proteins or peptides and enzymes from snake venom when isolated and evaluated may bind specifically to cancer cell membranes, affecting the migration and proliferation of these cells. Some of substances found in the snake venom present a great potential as anti-tumor agent. In this review, we presented the main results of recent years of research involving the active compounds of snake venom that have anticancer activity.