No abstract available.
Vitamin K Deficiency* ; Vitamin K* ; Vitamins*

No abstract available.
Vitamin K Deficiency* ; Vitamin K* ; Vitamins*

Background: Intracranial hemorrhage (lCH) is a common disease with high rate of mortality and neurological sequel. Objectives:to estimate preventive effectiveness of intracranial hemorrhage by vitamin K1 and K3 for newborns just after birth". Subjects and methods: An epidemiological, randomized control study with intervention was conducted. The study included all children under 3 months with and without ICH during period 1/1/2000 -30/6/2004 living in Hatay province. Among them all the newborns during period 1/6/2002 - 30/6/2004 were injected either 1 mg vitamin K1 or K3. Results: Children injected with vitamin K in the intervention period were followed up in three months and evaluated by a united process. Effects of intervention were calculated by preventive value. 62.057/82069 newborns were injected vitamin K1 or Vitamin K3 (25.725 newborns were injected Vitamin K1; 36.332 newborns were injected vitamin K3). Single dose 1M reduced the rate of ICH in infants: The morbidity changed from 3.3\ufffd?to 0.82\ufffd? the prevention value was 96%. There were no complications and side effects of vitamin K injections reported. Conclusions: Injection of vitamin K1 and K3 have similar preventive effectiveness. Vitamin K injection 1M with recommended dose was safe for newborns.\r\n', u' \r\n', u'\r\n', u'
Intracranial Hemorrhages ; Vitamin K Deficiency

No abstract available.
Humans ; Infant, Newborn* ; Vitamin K Deficiency* ; Vitamin K* ; Vitamins*

No abstract available.
Diagnosis* ; Intracranial Hemorrhages* ; Vitamin K Deficiency* ; Vitamin K* ; Vitamins*

No abstract available.
Diagnosis* ; Intracranial Hemorrhages* ; Vitamin K Deficiency* ; Vitamin K* ; Vitamins*

A hemorrhagic disease due to prothrombin complex deficiency os described in 4 infants from 1 to 11 months of age. This disease is different from the hemorrhagic disease of the newborn. The main differences are that it is found in an older age group and that intracranial hemorrhages are frequent. Rapid clinical and laboratory response after vitamin K therapy are observed. Severe prothrmbin complex deficiency due to vitamin K deficiency is a accounted for the pathogenesis of bleeding. Possible causes of vitaimn K deficiency are reviewed.
Hemorrhage ; Humans ; Infant ; Infant, Newborn ; Intracranial Hemorrhages ; Prothrombin ; Vitamin K ; Vitamin K Deficiency

Hemorrhage ; etiology ; physiopathology ; Humans ; Time Factors ; Vitamin K Deficiency ; complications

Vitamin K intake has been reported as an essential factor for bone formation. The current study was conducted under the hypothesis that insufficient vitamin K intake would affect inflammatory markers and bone mineral density in young adult women. The study was a cross-sectional design that included 75 women in their 20s. Physical assessments, bone mineral density measurements, 24-hr dietary recalls, and biochemical assessments for high sensitivity C-reactive protein (hs-CRP) and percentages of undercarboxylated osteocalcin (%ucOC) were performed. An analysis of vitamin K nutritional status was performed comparing first, second, and third tertiles of intake based on %ucOC in plasma. Vitamin K intake levels in the first, second, and third tertiles were 94.88 +/- 51.48 microg, 73.85 +/- 45.15 microg, and 62.58 +/- 39.92 microg, respectively (P < 0.05). The T-scores of the first and third tertiles were 1.06 and -0.03, respectively, indicating that bone mineral density was significantly lower in the group with lower vitamin K intake (P < 0.05). There was a tendency for different serum hs-CRP concentrations between the first (0.04 +/- 0.02) and third tertiles (0.11 +/- 0.18), however this was not statistically significant. Regression analysis was performed to identify the correlations between vitamin K nutritional status, inflammatory markers, and bone mineral density after adjusting for age and BMI. Serum hs-CRP concentrations were positively correlated with vitamin K deficiency status (P < 0.05). And bone mineral density, which was represented by speed, was negatively correlated with vitamin K deficiency status (P < 0.05). In conclusion, status of vitamin K affects inflammatory status and bone formation. Therefore, sufficient intake of vitamin K is required to secure peak bone mass in young adult women.
Bone Density ; C-Reactive Protein ; Female ; Humans ; Nutritional Status ; Osteocalcin ; Osteogenesis ; Plasma ; Vitamin K ; Vitamin K Deficiency ; Vitamins ; Young Adult

Clinical findings in neonates and infants with cholestasis characteristically include prolonged jaundice, acholic stool, pruritus and failure to thrive. We report two cases of cholestasis presenting with spontaneous bleeding due to vitamin K deficiency. Laboratory studies on admission revealed moderate liver dysfunction and a bleeding tendency due to vitamin K deficiency. After administration of vitamin K, the bleeding tendency disappeared. Vitamin K deficiency was resulting from a combination of cholestasis-induced fat malabsorption and low vitamin K supplementation due to breast-milk feeding. Cholestasis should be considered in neonate and infant with a bleeding tendency.
Cholestasis* ; Failure to Thrive ; Hemorrhage* ; Humans ; Infant ; Infant, Newborn ; Jaundice ; Liver Diseases ; Pruritus ; Vitamin K Deficiency* ; Vitamin K* ; Vitamins*