1.Heterotopic ossification in skeletal muscle metastasis from colonic adenocarcinoma--a case report.
Venkatesh R Naik ; Hasnan Jaafar ; Samarendra S Mutum
The Malaysian journal of pathology 2005;27(2):119-21
Colonic adenocarcinoma metastasising to the skeletal muscle is rare. A-56-yr-old Malay man was diagnosed to have adenocarcinoma of the right colon [Dukes B] for which a right hemicolectomy was performed, followed by radiotherapy and chemotherapy. Five years later the patient presented with a mass in the rectus abdominis muscle. The serum carcinoembryonic antigen was 71 ng/Ml. The mass was resected. Gross and microscopical examination showed multiple deposits of mucin-secreting adenocarcinoma with prominent heterotopic ossification in the stroma. The exact pathogenesis and significance of heterotopic ossification is not clear, but bone morphogenetic proteins may play an important role.
Adenocarcinoma
;
Muscle, Skeletal
;
Heterotopic
;
Neoplasm Metastasis
;
Mass, NOS
2.Melanocytic variant of medullary thyroid carcinoma in a previously treated papillary carcinoma patient.
Irfan MOHAMAD ; Nazli ZAINUDDIN ; Norzaliana ZAWAWI ; Venkatesh R NAIK
Annals of the Academy of Medicine, Singapore 2011;40(6):300-301
Calcitonin
;
Carcinoma, Papillary
;
drug therapy
;
pathology
;
surgery
;
Female
;
Humans
;
Melanins
;
Melanocytes
;
cytology
;
pathology
;
Middle Aged
;
Prognosis
;
S100 Proteins
;
Thyroid Neoplasms
;
drug therapy
;
pathology
3.Prevalence of goblet cell metaplasia in endocervical and endometrial adenocarcinoma: A histochemical study.
Lauren Nieuwenhuizen ; Mohd Khairy Khalil ; Venkatesh R. Naik ; Nor Hayati Othman
Malaysian Journal of Medical Sciences 2007;14(1):56-61
To determine the prevalence of goblet cell metaplasia in endocervical and endometrial adenocarcinomas by histochemial staining and to investigate the most sensitive histochemical staining method to detect this metaplasia, a total of 90 tissue blocks representing 30 non-neoplastic cervix, 30 non-neoplastic endometrium, 30 endocervical and endometrial adenocarcinoma cases were obtained for histochemical staining with Toluidine Blue (TB), Methylene Blue (MB), Mucicarmine (MUC), Periodic Acid Schiff before and after Diastase digestion (PAS, PAS-D), Alcian Blue pH 2.5 (AB), and Periodic Acid Schiff after Alcian Blue pH 2.5 (PAB). The cases were blinded and evaluated by a pathologist [NHO] for the presence of goblet cell metaplasia, the amount of goblet cells present and the histochemical differentiation of the goblet cells compared with its surrounding glandular epithelium. Goblet cell metaplasia was present in 2 out of 30 cases in non-neoplastic cervix, 0 out of 30 cases in non-neoplastic endometrium, 7 out of 15 cases in endocervical adenocarcinoma and in 2 out of 15 cases in endometrial
adenocarcinoma. Relatively few goblet cells were seen in endometrial adenocarcinoma, few to moderate amounts were seen in endocervical adenocarcinoma and relatively more goblet cells were seen in non-neoplastic cervix. The differentiation of the goblet cells with its surrounding glandular epithelium was moderate to strong in non-neoplastic cervix and endocervical adenocarcinoma, while the differentiation in endometrial adenocarcinoma was weak to moderate. The various staining methods showed differences in presence, amount anddifferentiation of the goblet cells. Goblet cell metaplasia of the reproductive organs is not as rare as previously reported. There was no statistical difference in presence, amount and differentiation of goblet cells according to the various cases. The must optimum staining methods for staining goblet cells in non-neoplastic cervix, endocervical adenocarcinoma and endometrial adenocarcinoma were PAS, PASD and AB.
4.Brain Metastasis of Atrial Myxoma: Case report
Badrisyah Idris ; Saiful Razman ; Rahmat Harun ; Venkatesh R Naik ; Tan Y C
The Medical Journal of Malaysia 2012;67(6):613-615
Metastasis of an atrial myxoma to the brain is extremely
rare1. Thus far there are only 17 cases reported, including
our present case. Most of the brain metastases manifest
only in 3 to 6 decades, after an average time frame of one to two years after surgical removal of parental tumour. We
present a case of brain metastases of atrial myxoma in a
teenager of the youngest age among all reported cases,
unusually as early as 15 years old 3. The progress of the
metastatic process had been insidious for three years after
heart surgery, The imaging demonstrated a rather sizeable
tumour by the time when the patient is symptomatic. The
location of the metastatic tumour is anyhow superficial to
the cortical surface, enabling complete surgical excision of the tumour easily achievable with favourable outcome.
5.Salivary duct carcinoma in the neck.
Mohd Izani SHIYUTI ; Irfan MOHAMAD ; Shah Jihan Wan DIN ; Venkatesh R NAIK ; Venkata M K BHAVARAJU
Annals of the Academy of Medicine, Singapore 2011;40(10):473-474
Carcinoma, Ductal
;
pathology
;
surgery
;
Female
;
Head and Neck Neoplasms
;
pathology
;
surgery
;
Humans
;
Middle Aged
;
Neck Dissection
;
Salivary Ducts
;
pathology
;
surgery
6.Large full thickness medial canthal reconstruction: a report of two cases and review of literature
Nor Idahriani Muhd Nor ; Azhany Yaakub ; Venkatesh R. Naik ; Wan Hazabbah Wan Hitam ; Liza Sharmini Ahmad Tajudin
Archives of Orofacial Sciences 2012;7(1):28-33
The reconstruction of the upper eyelid with medial canthal involvement post extensive removal of malignant tumour remains a challenge. Proper eyelid reconstruction is necessary to re-establish anatomic integrity, restoration of its functions and to maintain the best cosmetic appearance. These case reports illustrate an alternative reconstructive technique for large upper eyelid full thickness defect with medial canthal involvement. Two cases of upper eyelid tumours involving medial canthal region underwent staged reconstruction by glabellar flap advancement and reconstruction of the posterior lamellar with autologous graft using buccal mucosa and ear cartilage. The posterior lamellar graft and flap survived without any complication except for mild eyelid margin notching in one of the two cases. The staged reconstruction with glabellar flap advancement provides adequate defect coverage, excellent blood supply, maintains eyebrow contour and function of the eyelid. The flap also perfectly matches the surrounding tissue with minimal donor site morbidity.