We experienced a case of D3 proliferative vitreoretinopathy complicated with a shortened retina in a 31-year-old male which was managed using 360-degrees circumferential retinotomy technique and a case of D1 proliferative vitreoretinopathy complicated with a shortened retina in a 26-year-old female which was managed using 260-degrees circumferential retinotomy technique. We report these cases with a review of the literature
Adult ; Female ; Humans ; Male ; Retina* ; Vitreoretinopathy, Proliferative

Perfluorodecalin, which is one of the perfluorocarbon liquids, is not established safety in use of long-acting intraocular tamponade. Therefore, to determine its safety we injected it alone and combined with silicone oil into the vitreous of vitrectomized eyes. We evaluated the changes of the fundus, electroretinogram, histopathology as light and electron microgragh after lensectomy and vitrectomy in pigmented rabbits periodically. In rabbits replaced with perfluorodecalin alone, fundus showed mild proliferative vitreoretinopathy and micrographs showed the destruction of the inner and outer segments of the photoreceptors. In rabbits replaced with perfluorodecalin and silicone oil, fundus showed more severe proliferative vitreoretinopathy than perfluorodecalin alone and micrographs showed the destruction of the entire retina. In electroretinogram, the amplitude was decreased markedly. So, it is considered that perfluorodecalin was not tolerant in case of longacting intraocular tamponade and also perfluorodecalin combined with silicone oil developed severe proliferative vitreoretinopathy.
Rabbits ; Retina ; Silicone Oils* ; Vitrectomy ; Vitreoretinopathy, Proliferative

Several studies have indicated that retinal pigment epithelial(RPE) cells migrate from their normal location into the vitreous cavity where they then undergo proliferation and membrane formation in proliferative vitreoretinopathy(PVR). Little attention has been given to the role of vitreous on cellular proliferation. Our study is to determine the effect of vitreous on RPE cell proliferation and to examine the morphology of cultured RPE cells on vitreous explants. The vitreous from pigmented rabbit was extracted and added to the cultured media RPE cells proliferated rapidly along the margin of the vitreous as fibrocyte like cells and were less invasive into the virtrous gel. Liquified vitreous with media stimulated the proliferation of RPE cells, but vitreous alone showed the decrease of inoculated RPE cells.
Cell Proliferation ; Membranes ; Retinaldehyde* ; Vitreoretinopathy, Proliferative

The authors performed experimental study to produce proliferative vitreoretinopathy by intravitreal injection of homologous fibroblasts in pigmented rabbits. Twenty four eyes of 12 rabbits were divided into control and experimental groups. In experimental group, the eyes were pretreated with expanding gas, perfluoropropane for the vitrectomy. In control group, no such procedure was preceded. In both groups, 5.0×10⁴, 1.0×10⁵ and 1.5×10⁵ cells of homologous fibroblasts were injected into the vitreous cavity. All the eyes were observed regularly with indirect ophthalmoscope followed by fundus photography. Those eyes were enucleated in 1, 2, 4 weeks for the light and electron microscopic studies. The development and severity of the proliferative vitreoretinopathy were correlated with the numbers of the injected fibroblast. This was more pronounced in the experimental group.
Fibroblasts ; Intravitreal Injections ; Ophthalmoscopes ; Photography ; Rabbits ; Vitrectomy ; Vitreoretinopathy, Proliferative*

We reviewed 71 cases of silicone oil injection for retinal detachment surgery with advanced proliferative vitreoretinopathy following failed vitrectomy between November 1982 and March 1986 in order to identify the anatomic and functional success rate and its complications. The causes of vitrectomy were as follows: advanced proliferative vitreoretinopathy after retinal detachment surgery and retinal vascular diseases(34 eyes), giant dialysis(10 eyes), severe perforating injuries and intraocular foreign bodies(17 eyes), and traction retinal detachments associated with proliferative diabetic retinopathy(10 eyes). In 71 cases of silicone oil injection, anatomic success rate was 34.8%(23/66) and functional success rate was 16.9%(16/71) and its complications were lens opacities(28.1%, 9/32) in phakia and corneal opacities(20.5%. 8/39) and increased intraocular pressure(17.9%, 7/39) in aphakia.
Aphakia ; Retinal Detachment* ; Retinaldehyde* ; Silicone Oils* ; Traction ; Vitrectomy* ; Vitreoretinopathy, Proliferative*

We reviewed charts of patients on the clinical characteristics and factors which affect the prognosis of surgical results in the 77 patients(77 eyes) who were diagnosed with rhegmatogenous retinal detachment and operated on and followed for at least 3 months postoperatively at Korea University Guro hospital. We evaluated the characteristics of rhegmatogenous retinal detachment in Korea by comparing with other reports on retinal detachment as well. The factors associated with anatomic success were the duration of retinal detachment and the prescence of proliferative vitreoretinopathy. High success rate was achieved when the duration was less than 1 month and there was no proliferative vitreoretinopathy. The factors associated with functional success included the duration of retinal detachment, proliferative vitreoretinopathy, preoperative refractive error and the degree of retinal detachment(P<0.05).
Humans ; Korea ; Prognosis ; Refractive Errors ; Retinal Detachment* ; Retinaldehyde* ; Vitreoretinopathy, Proliferative

Scleral buckling used alone to treat retinal detachment with proliferative vitreoretinopathy(PVR) of grade C resulted in an overall anatomic reattachment rate of 86%(39/45); 96%(27/28) in stage C1, 83%(10/12) in stage C2, and 40%(2/5) in stage C3. The success rate declined with increasing severity of PVR. Stage C3 eyes showed a significantly lower rate of retinal reattachment than stage C1 and C2 eyes(p<.05). We currently recommend scleral buckling alone as the surgery of choice for stage C1 and C2 PVR; we reserve vitrectomy with preretinal membrane removal for the more advanced cases.
Membranes ; Retinal Detachment ; Retinaldehyde ; Scleral Buckling* ; Vitrectomy ; Vitreoretinopathy, Proliferative*

Inspite of technical advances, the need for pharmacologic treatment of proliferative vitreoretinopathy was increased. In order to evaluate the antiproliferative effect of various antimetabolites to the rabbit retinal pigment epithelial cell, we treated cultured rabbit retinal pigment epithelial cell with different concentration of drugs to perform dose inhibition studies. We found that the antimetabolites inhibited the proliferation of rabbit retinal pigment epithelial cell in a dose dependent and a time dependent manner. The drug concentration required for 50% inhibition of cell growth (ID50) were found to be as follows (BCNU; 6.51 mg/L, 5-FU ; 8.94 mg/L, Daunorubicin; 0.03mg/L, Mitomycin-C; 0.26mg/L).
Antimetabolites* ; Daunorubicin ; Epithelial Cells* ; Fluorouracil ; Mitomycin ; Retinaldehyde* ; Vitreoretinopathy, Proliferative

We studied retrospectively the results of consecutive vitrectomy following traumatic ruptured globe repair in 31 patients, who had been followed six months or longer postoperatively. Twenty-seven patients (87%) were male and 21 (68%) were between the second and fourth decades. Functional success was achieved in 13 patients(42%) and anatomic success in 14 patients(45%). Nine patients vitrectomized within two weeks after primary repair had 100% success rate, and seven patients operated between two weeks and one month had 96% success rate, but 15 patients vitrectomized after one month had 80% success rate. Five among eight eyes which underwent other operations prior to vitrectomy showed success, in contrast to 96% (22 eyes) success among 23 eyes which underwent planned vitrectomy without any other intervening surgical procedure. Better previtrectomy conditions including simple vitreoretinal incarceration or proliferative vitreoretinopathy of Grade B or milder achieved success in 96%, but poor conditions including prephthisical status and proliferative vitreoretinopathy of Grade C or more severe in 67% In conclusion, the overall success rate of consecutive vitrectomy in repaired ruptured globe was 87%. Prephthisical condition and severe proliferative vitreoretinopathy showed poor prognosis. We emphasize the necessity of well-planned vitreous surgery and the importance of its adequate timing in the management of penetrating injury.
Humans ; Male ; Prognosis ; Retrospective Studies ; Vitrectomy* ; Vitreoretinopathy, Proliferative

In vitro PVR(Proliferative vitreoretinopathy) models allow identification of factor which may inhibit porliferation and contraction. In this study we evaluated the contraction of collagen matrix by choroidal fibroblast and the inhibition of contraction by antipoliferative drug. Each antiproliferative drug showed inhibition of collagen matrix contraction : Colchicine (0.1microgram/ml), Cytochalacin (0.05microgram/ml), Puromycin(10microgram/ml). Transmission electron microgram of collagen matrices containing colchicine, cytochalacin or puromycin showed no collagen fiber surrounding choroid fibroblast and showed cell destruction. Scanning electron microgram of collagen matrices containing colchicine, cytochalacin and puromycin showed that collagen fibers were well preserved without distortion. Colchicine, cytochalacin and puromycin are effective inhibitor of cell mediated contraction in additon to it`s potent antiproliferative effect wherease Interfereon has no anticontractile effect. The current study present a model to investigate the effect of antiproliferative drug on fibroblast mediated collagen matrix contraction.
Choroid ; Colchicine ; Collagen* ; Fibroblasts ; Interferons ; Puromycin ; Vitreoretinopathy, Proliferative