1.Studies on HPLC fingerprint of the hydrophilic constituents of Valeriana medicinal plants.
Jin-Li SHI ; Yong LIU ; Pei-Gen XIAO
China Journal of Chinese Materia Medica 2005;30(6):426-429
OBJECTIVETo establish the fingerprint of the hydrophilic constituents of Valeriana medicinal plants.
METHODThe HPLC-UV assay was used to establish the fingerprint of the hydrophilic constituents of Valeriana medicinal plants.
RESULTThe HPLC fingerprint profiles of the hydrophilic constituents of Valeriana medicinal plants contains 12 common peaks. The relative retention time and the ranges of relative area of the common peaks were determined.
CONCLUSIONThe fingerprint profile can be used for the identification and quality control of Valeriana medicinal plants.
Chromatography, High Pressure Liquid ; methods ; Plant Roots ; chemistry ; Plants, Medicinal ; chemistry ; Quality Control ; Valerian ; chemistry
2.Chemical constituents from whole plants of Valeriana hardwickii.
Shi-wei CHAI ; Yong-song ZHAI ; Man-yuan WANG
China Journal of Chinese Materia Medica 2015;40(20):4007-4011
Chemical investigation of the whole plants of Valeriana hardwickii has led to the isolation of 11 flavones and 2 monoterpe- noids by using various chromatographic techniques including column chromatography on silica gel and Sephadex LH-20, preparative TLC, and preparative HPLC. Their structures were identified by spectroscopic data analysis as syzalterin (1), 6-methylapigenin (2), 5-hydroxy-7,4'-dimethoxyflavone (3), genkwanin (4), acacetin (5), apigenin (6), quercetin (7), tricin (8), (-)-farrerol (9), sosakuranetin (10), 5,3',4'-trihydroxy-7-methoxyflavanone (11), (-)-bornyl ferulate ( 12) , and (-)-bornyl caffeate ( 13). All compounds were isolated from this plant for the first time, while compounds 1, 9-13 were obtained from this genus for the first time.
Drugs, Chinese Herbal
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chemistry
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isolation & purification
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Molecular Structure
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Spectrometry, Mass, Electrospray Ionization
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Valerian
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chemistry
3.Preparation and evaluation of valerian oil-beta-cyclodextrin inclusion complex.
Qi SI ; Dan WU ; Qing-Ri CAO ; Jing-Hao CUI
China Journal of Chinese Materia Medica 2013;38(14):2309-2313
The aim of this study was to improve the stability and cover the unpleasant odor of valerian oil by preparation of beta-cyclodextrin inclusion complex. The preparation method was established based on the yield of inclusion complex and entrapment efficiency of valerian volatile oil. After that, the formulation and processing parameters were optimized by uniform design table. The formations of inclusion complex were validated by DSC and X-RD method. The stability of valerian oil beta-cyclodextrin inclusion was studied under stressed conditions. In conclusion, relatively high yield of inclusion complex and entrapment efficiency were obtained by saturated solution-ultrasonication method. Inclusion complex yield and entrapment efficiency of the valerian oil were (84.78 +/- 3.23)% and (86.23 +/- 2.48)%, which were prepared under the optimized conditions, respectively. The results of DSC and X-RD were indicated the formation of inclusion complex. The stability of test showed that the valerian oil-beta-cyclodextrin inclusion complex was improved significantly.
Drug Stability
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Drugs, Chinese Herbal
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chemistry
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Odorants
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Oils, Volatile
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chemistry
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Valerian
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chemistry
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beta-Cyclodextrins
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chemistry
4.Development and research advances of iridoids from Valeriana jatamansi and their bioactivity.
Ning-ning ZHANG ; Guang-zhi DING
China Journal of Chinese Materia Medica 2015;40(10):1893-1897
Valeriana jatamansi (syn. V. wallichii), a traditional Chinese medicine recorded in Chinese Pharmacopeia (1977 and 2010 edition), has been used for treatment of a variety of conditions including sleep problems, obesity, nervous disorders, epilepsy, insanity, snake poisoning, eye trouble, and skin diseases. Also, it was used as an important substitute for the European V. officinalis, whose root preparation, popularly known as valerian, has been employed as a mild sedative for a long time. In recent years, much attention has been draw to the iridoids, one of the major bioactive constituents of V. jatamansi, leading to the discovery of a series of new iridoids with anti-tumor and neuroprotective activities. Their action machnism also has been discussed. This paper summerized the iridoids and their bioactivities from V. jatamansi in recent years, which could provide basic foundation for development and research of V. jatamansi.
Animals
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Drugs, Chinese Herbal
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chemistry
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pharmacology
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Humans
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Iridoids
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chemistry
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pharmacology
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Valerian
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chemistry
5.Pharmacologic misadventures with herb-drug interactions
Philippine Journal of Anesthesiology 2003;15(2):82-89
This article review and discuss the complimentary and alternative medicine (CAM), where it all began, practices and ideas self- defined by their users as preventing and treating illnesses or promoting health and well-being.
HERB-DRUG INTERACTIONS
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HERBALS
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ECHINACEA
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TANACETUM PARTHENIUM
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GARLIC
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GINKGO BILOBA
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PANAX
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KAVA
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VALERIAN
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HYPERICUM
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EPHEDRA
6.A Systematic Review and Meta-analysis on the Effect of Herbal Medicine to Manage Sleep Dysfunction in Peri- and Postmenopause
Talat KHADIVZADEH ; Somayeh ABDOLAHIAN ; Masumeh GHAZANFARPOUR ; Leila KARGARFARD ; Fatemeh Rajab DIZAVANDI ; Imaneh KHORSAND
Journal of Menopausal Medicine 2018;24(2):92-99
OBJECTIVES: Some conventional medications used to treat insomnia, such as benzodiazepine, non-benzodiazepine, and hormone therapy, are associated with side effects. Therefore, there is a growing interest in the use of herbal medicine. The aim of this systematic review is to assess the effects herbal medicines have on sleep disorders of peri- and postmenopausal women. METHODS: Three databases were searched including MEDLINE, Scopus, and the Cochrane Library from inception to March 2018. RESULTS: Six trials assessed the effect of soy on sleep disorders. Forrest plot for 2 studies showed that the standardized mean difference (SMD) of the sleep problems was lower in the soy group than the placebo group (SMD = −0.996; P < 0.001; 95% confidence interval, −1.42 to −0.563). Three trials showed soy had no significant effect on sleep disorders and one study showed a positive effect on sleep disorders. Accordingly, it is difficult to reach a definite conclusion regarding the effects of soy on sleep disorders based on these findings. According to a trial, significant beneficial effect associated with taking Schisandra chinensis. Findings suggested that some herbal medicines like red clover, lavender combined with bitter orange and pin bark extract had attenuating effects on sleep disorders. After intake of 530 mg of valerian twice a day for one month, statistically significant effects were observed regarding the quality of sleep of postmenopausal women. CONCLUSIONS: The present systematic review and meta-analysis found inadequate evidence to draw conclusions regarding the effectiveness of herbal medications, especially soy.
Benzodiazepines
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Citrus sinensis
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Female
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Herbal Medicine
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Humans
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Lavandula
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Postmenopause
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Schisandra
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Sleep Initiation and Maintenance Disorders
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Sleep Wake Disorders
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Trifolium
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Valerian
8.Advance of pharmacological studies on Valeriana jatamansi.
Chang CHEN ; Shaojing LI ; Shihuan TANG ; Hongwei WU ; Haiyu XU ; Hongjun YANG ; Zhiyong YAN
China Journal of Chinese Materia Medica 2012;37(14):2174-2177
As a traditional Chinese medicine, Valeriana jatamansi has a long history of application in China. It is widely distributed and commonly adopted by many ethnic groups. In particular, its roots have a wide range of medicinal value. With the increasingly more attention on it from domestic and foreign researchers, there have been more and more studies on its pharmacological activity and mechanism. This essay summarizes domestic and foreign reports on its pharmacological activity and mechanism.
Animals
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Anti-Infective Agents
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pharmacology
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Antihypertensive Agents
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pharmacology
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Antineoplastic Agents, Phytogenic
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pharmacology
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Central Nervous System Depressants
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pharmacology
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Gastrointestinal Tract
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drug effects
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Humans
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Plant Extracts
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adverse effects
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pharmacology
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Valerian
9.Chemical constituents from ethyl acetate-soluble extraction of Valeriana jatamansi.
Sheng LIN ; Peng FU ; Yun-Heng SHEN ; Ji YE ; Zhong-Xiao ZHANG ; Xian-Wen YANG ; Hui-Liang LI ; Run-Hui LIU ; Xi-Ke XU ; Wei-Dong ZHANG
China Journal of Chinese Materia Medica 2018;43(1):100-108
Application of a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, macroporous adsorbent resin, and reversed-phase HPLC, led to the isolation of 173 compounds including irdidoids, monoterpenes, sesquiterpenes, triterpenes, lignans, flavonoids, and simple aromatic derivatives from the ethyl acetate-soluble fraction of the whole plants of Valeriana jatamansi(Valerianaceae), and their structures were elucidated by spectroscopic methods including 1D, 2D NMR UV, IR, and MS techniques. Among them, 77 compounds were new. In previous reports, we have described the isolation, structure elucidation, and bioactivities of 68 new and 25 known compounds. As a consequence, we herein reported the isolation and structure elucidation of the remaining 9 new and 71 known compounds, the structure revision of valeriotriate A(8a), as well as cytotoxicity of some compounds.
Acetates
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Chromatography, High Pressure Liquid
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Flavonoids
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analysis
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Iridoids
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analysis
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Lignans
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analysis
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Molecular Structure
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Monoterpenes
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analysis
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Phytochemicals
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analysis
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Plant Extracts
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chemistry
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Sesquiterpenes
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analysis
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Triterpenes
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analysis
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Valerian
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chemistry
10.Effect of Valeriana jatamansi extract on fecal UPLC-MS/MS metabolomics in rats with diarrheal irritable bowel syndrome.
Yao-Yu LIU ; Fang-Yuan MU ; Yi-Cheng WANG ; Man-Yu WANG ; Chun-Guo WANG ; Xing-Li YAN
China Journal of Chinese Materia Medica 2021;46(3):678-684
The purpose of this study was to understand the pharmacodynamic effect of Valeriana jatamansi extract in diarrhea predominant irritable bowel syndrome(IBS-D) rat model induced by maternal separation combined with three kinds of stress, and observe the changes of endogenous metabolites in feces after intervention to find potential biomarkers and related metabolic pathways. The animal model of IBS-D was established by maternal separation combined with restraint, ice swimming and tail clamping. The therapeutic effect of each dose group of V. jatamansi extract was evaluated in terms of abdominal withdrawal reflex pressure threshold, fecal water content and immobility time of forced swimming test. In addition, rat feces were collected for detection of metabolic profiles of small molecular metabolites with UPLC-LTQ-Orbitrap MS platform, so as to find the biomarkers of differential metabolism with multivariate statistical analysis methods such as principal component analysis(PCA) and orthogon partial least squares discrimination analysis(OPLS-DA). The results showed that as compared with the normal group, the threshold of abdominal withdrawal reflex pressure was decreased, the fecal water content was increased, and the immobility time of forced swimming test was prolonged in the model group. The results of fecal metabonomics showed that the levels of 39 metabolites were down-regulated and those of 37 metabolites were up-re-gulated. Further analysis showed that these metabolites were related to bile acid metabolism, unsaturated fatty acid metabolism, amino acid metabolism, ceramide metabolism and other metabolic pathways. This study proved that the extract of V. jatamansi had definite pharmacodynamic effect on IBS-D model rats, and the mechanism was discussed from the perspective of fecal metabonomics.
Animals
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Chromatography, High Pressure Liquid
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Chromatography, Liquid
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Diarrhea
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Feces
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Irritable Bowel Syndrome/drug therapy*
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Maternal Deprivation
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Metabolomics
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Rats
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Tandem Mass Spectrometry
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Valerian