1.Diagnosis of acute and chronic pancreatitis and differential diagnosis
Badamsed Ts ; Uyanga M ; Bilguun N
Mongolian Medical Sciences 2014;169(3):26-32
Background
Abdominal ultrasonography assesses the size, echotexture, shape, contour and adjacent structures of
pancreas.
Goal
The goal of our study is to determining ultrasonography criteria of acute and chronic pancreatitis and
developing algorithm of differential diagnosis.
Objectives
1. To determine ultrasonography criteria of acute and chronic pancreatitis
2. To develop algorithms of differential diagnosis of acute and chronic pancreatitis
Material and Method
During the study period, 81 patients with acute pancreatitis, 66 patients with chronic pancreatitis has
examined byultrasonography in Reference centre on Diagnostic Imaging named after R. Purev state
laureate, people’s physician,hoporary professor of the State III nd Central Hospital,AchtanClinicalHospi
tal,Central Clinic of Ulaanbaatar railway and Hepatological clinic centre of traditional medicine
Result
48 (59.3%±5.5) patients with acute pancreatitis had reported pancreatic swelling /Exudative pancreatitis/,
18 (22.2%±466) had acute hemorrhagic pancreatitis, 15 (18.5%±463) had necrotizing pancreatitis.
Conclusions
1. Determined ultrasonographic criteria of acute and chronic pancreatitis
2. Acute and chronic pancreatitis has diagnosed by ultrasonographic criteria and developed differential
diagnosis algorithm.
2. COMPARATIvE STUDY OF SOLUTION OF DICLOFENAC SODIUM TABLET, PRODUCED IN VARIOUS COUNTRIES, IN DIFFERENT SOLVENT MEDIA BY THE in vitro METHOD
N. Khishigsuren ; U. Uyanga ; D. Khongorzul
Mongolian Pharmacy and Pharmacology 2013;2(1):29-
Introduction: the background and importance of present research work consists on demonstrating how the drug substance digestion changes depending from the media of fluid to be taken. Purpose: consists in comparative study of solution of the diclofenac sodium film coated tablets, produced in various countries, in different solvent media by the in vitro method. Materials and Methods: the solution research of each 50mg total 54 pieces of film coated diclofenac sodium, produced in three different factories such as A, B and C, was conducted in three different medias in juice (pH=3.8); distilled water (pH=6.7) and mineral water (pH=6). The solution was determined in centrifuge and measured 276 nm in spectrophotometer. Result: the solution of 50mg diclofenac sodium film coated tablet, produced in three different countries such as A,B and C: • The amount of drug substance released in the distilled water (pH=6.7) media has been counted in 15 minutes after begin of solution process the A factory-66%, the B factory-58% and the C factory-20%. At continuation of duration of solution had in 30 minutes the A factory-80%, the B factory-86%, the C factory-72%; in 45 minutes the A factory-82%; the B factory-88%; the C factory-66%; in 60 minutes the A factory-82%; the B factory-82%; the C factory-72% each respectively. • The amount of drug substance released in the juice (pH=3.8) media has been counted in 15 minutes after begin of solution process the A factory-50%, the B factory-42% and the C factory-60%. At continuation of duration of solution had in 30 minutes the A factory-82%, the B factory-40%, the C factory-72%; in 45 minutes the A factory-80%; the B factory-44%; the C factory-38%; in 60 minutes the A factory-56%; the B factory-66%; the C factory-58% each respectively. • The amount of drug substance released in the mineral water (pH=6) media has been counted in 15 minutes after begin of solution process the A factory-54%, the B factory-30% and the C factory-10%. At continuation of duration of solution had in 30 minutes the A factory-66%, the B factory-62%, the C factory-36%; in 45 minutes the A factory-82%; the B factory-82%; the C factory-38%; in 60 minutes the A factory-74%; the B factory-84%; the C factory-74% each respectively. Conclusion: from the above-mentioned experiment it is evident that the solution of the diclofenac sodium film coated tablet, produced in different countries, in different solvent media as distilled water, juice and mineral water is relatively different. It has showed how important is to take into account the auxiliary substance quality contained in current drug at choosing the fluid to be taken after the drug. Bibliography: - “Drug analysis” D. Dungerdorj, Z.Anuu 2012 - “Bioformation” A.I. Tikhonov, T.G. Yarnykh, I.A. Zupanets, O.S. Danikevich, E.E. Bogutskaya, N.V. Bezdetko, Yu.N. Azarenko 2003
3.Comparative Effects of Aqueous Solution of Juniper Berry and Gold Extract on Mechanical Bone Injury in Rabbit Marrow
Uyanga B ; Ariunjargal N ; Seesregdorj S
Journal of Oriental Medicine 2012;2(1):56-59
Recent years non communicable disease moribidity isincreasing due to broken bone caused by bone rarity and accident. National Trauma Orthopedic Research Center (2009) survey showed that in recent years the number of inpatients broken bone is 30.8% and 60.5% of this people concern tibial fracture. Recovery after bone rarity and bone breakage is important. To aid faster recovery, traditional medicine often used Calcite and Rhodiola rosea. L to cure breakage. It attracts attention that Natural calcite consistsof 10 minerals and almost 64% of calcum. In our study, we used masculine calcite from Bayankhongor aimag “ Tsagaanagui”, Altpant which made from Rhodiola rosea basis and 30 rabbits from “Introduction of corporation of traditional medical science, technology” laboratory. We observed rabbits at 2nd, 14th, 28h, 49th, 60thdays controlled with 2 angle projection using Hitachi-TU 51 X ray machine. Also, at the 7th, 28th, 60thdays samples were taken for histopathology analysis. As a result, control group had 10 degree turn as compared to calcite treated group. However both group rabbits were healing fine. In histological analyses callus and endost were fine. Osteoblast structure is fine, osteocite is placed in lacun. Volkmann cannal is seen good.
4.ANTIBACTERIAL ACTIVITY OF TRADITIONAL MEDICINE “TIISHAL” AND ITS FIVE COMPONENT HERBS
Khongorzul U ; Uyanga N ; Sukhdolgor J ; Batjargal B
Innovation 2018;12(1):31-34
BACKGROUND. Traditional medicine is the oldest form of health care in the world and is used in the prevention and treatment of physical and mental illnesses3. Traditional medicine is also variously known as complementary and alternative, or ethnic medicine, and it still plays a key role in many countries today11. Plant produces a wide variety of secondary metabolites which are used either directly as precursors or as lead compounds in the pharmaceutical industry. It is expected that plant extracts showing target sites other than those used by antibiotics will be active against drug resistant microbial pathogens7.
Antibacterial activities of various extracts, including methanol, ethanol, butanol and ethyl acetate crude extracts from traditional Tiishal medicine and its medicinal plants ingredients were carried out. Staphylococcus aureus, Pseudomonas aeruginosa, Micrococcus luteus, Salmonella enterica. For this purpose extract of drug Tiishal were prepared and tested by “Disc Diffusion Method”. As a result of this study it was found that the extract of Tiishal generally revealed antimicrobial activity against both gram positive bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Micrococcus luteus) and gram-negative bacteria (Salmonella enterica). The to study found that antibacterial activity of the ethanol extracts of each 6 samples showed little inhibition on Sal. enterica.
METHODS. Traditional medicine Tiishal was produced from the Manba Datsan clinic and training center for traditional Mongolian medicine. Tiishal medicine was prepared by the standard MNS 5585:2006, № 0333151207 Tiishal medicine instructional method. The main medicinal herbs of Tiishal include Juniperus pseudosabinaFisch., Gentiana barbata Froel., Cynomorium songaricum Rupr., Sophora alopecuroides L., and Tricholoma mongolicum Imai (1:1:1:1:1) ratio. The antimicrobial activity of the ethanol, methanol, butanol and ethyl acetate extracts was carried by disc diffusion method.
RESULTS. A total 4 strains were used for the antibacterial activity test. The extracts of methanol, and ethanol of J. pseudosabina revealed the highest antibacterial activity against Bac. subtilis, Ps. aeruginosa, S. aureus, and S. enteric with the diameters of inhibition zones between 6.0 - 10.0 mm.
СONCLUSION. “Tiishal”, ethanol and methanol extracts of 5 different plants showed relatively low inhibition of bacterial growth.
5.Results of a questionnaire survey assessing the risk, habits, and attitudes of toxoplasmosis among herders in Khovd provinсе
Oyun B ; Uyanga B ; Burmaajav B ; Uranshagai N
Mongolian Medical Sciences 2024;210(4):45-52
Background:
Toxoplasmosis is an infection caused by the parasite Toxoplasma gondii. Cats are the
reservoir of the parasite. Humans can become infected either by ingesting the cysts (by
direct contact with cats or through food or water contaminated by cat faeces) or by eating
poorly cooked meat containing cysts. We aimed to study on knowledge, attitude, risk of
Toxoplasmosis among herder in Khovd province.
Materials and Methods:
Study methods: The study used a descriptive cross-sectional design and included herders
from Bulgan, Buyant, Darvi, Zereg, Myangad, Khovd, Erdeneburen, Jargalant soum, which
have the largest livestock number in Khovd province. A questionnaire was administered to
determine the knowledge, attitudes, and risk factors for toxoplasmosis among herders.
Study ethics:
Before starting the study, the methodology was discussed at a meeting of the
Ethics Committee of “Ach” University of Applied Sciences, and the research (Resolution No.
23/02) was approved.
Data processing:
The data collected during the study were coded into Microsoft Office Excel
and a database (file) was created. Open Epi Info and SPSS 20 were used to statistically
process the results of the study (mean, standard deviation, relative risk).
Result:
In result, 180 herder’s average age was 48.1±17.8 years old, most of them were female.
Most of herder were herding their livestock over six years. During their herding period, 31%
of herder household has registered rabies, anthrax, brucellosis, swine fever, blood infection,
blindness, smallpox, horse pox, scabies, foot and mouth disease among their livestock. By
questionnaire, toxoplasmosis has not registered among livestock. When assessing self
protection practices when dealing with suspected infected animals, 14-22.3% use masks
and aprons when dealing with sick animals, 1.4-3% use goggles, coveralls, and disinfectants,
and the lowest percentage is 0.2% of gloves. This indicates a very high risk of transmission
of zoonotic diseases among herder of Khovd province.
Conclusion
In our study, although no cases of toxoplasmosis were recorded among
livestock in the soums of the Khovd province by questionarie, the lack of self-protection
practices and attitudes against animal-to-human transmission and the high risk of infection
indicate the importance of disseminating information and organizing training on zoonotic
diseases
6.The Effect Of Elixir Subdued Calcite To Early Stagefracture Healing Of Rat Femur
Uyanga B ; Ariunjargal N ; Vaanchigsuren S ; Seesregdorj S
Journal of Oriental Medicine 2013;4(1):84-87
In recent years medicine faces growing number of bone fractures
caused by accident
injuries and osteoporosis, which became a big problem. Today in
medicine praxis Calcium supplements is widely used, however Lai B,
Cervell MJ’s research shows that using calcium during long time
conversely bad for stomach. We chose for our research work Calcite
known in traditional medicine as bone nutrition contains up to 67% of
calcium, attract our attention. Otherwise, elixir subdued calcite also
has a treatment action for gastric ulcer and protects stomach.
Therefore we made a fracture in a Kriscner wire using Bannarens
Einhorn method and at the early stage of fracture healing (2nd and
4th week) started observing the effect of elixir subdued calcite using
radiography analyses. At the result, our research showed that callus
of the group of rats used elixir subdued calcite are
statisticalsignificance more fast than the group which used calcium
supplement. However compared to the group used standard rat chow
ad libitum, the group which used calcite, curing effect statistically
accelerated in 28 days, while in 14 days there were no statistical
significant of difference. Finally, result shows that compared to other
groups elixir subdued calcite is accelerating the curing effect, but for
supervising later or posterior bone healing process there is a
requirement of using additional analysis methods.
7.Geographical Distribution of Tick Borne Encephalitis in Mongolia
Uyanga B ; Uranshagai N ; Burmaajav B ; Undraa B ; Tserennorov D ; Tsogbadrakh N
Mongolian Medical Sciences 2020;191(1):50-56
Background:
Medical geography deals with the application of major concepts and theories derived from human and
physical geography to issues of health and disease. Between1970-1980, Russian scientists were first
figured landscape, geographical distribution of TBE in Mongolia. Since human cases of TBD were
registered from 2005, around 2000 cases of TBD were registered. From 15% of diseases and 78%
of fatal cases were tick-borne encephalitis. Therefore, were tried to create current geographical
distribution of TBE in Mongolia and detect risk areas.
Мaterials and Methods:
287 TBE cases data, information of TBE positive tick and human data were analyzed which registered
in NCZD between 2005-2017. Arc GIS 9 were used for create map. Mongolian map was divided by 5
landscape range such as forest-taiga, forest-steppe, steppe, steppe-desert, gobi and high mountain.
Result:
In forest-taiga range, 57% of TBE cases and incidence was 9.51 per 10000 population. 56.4%
of I.persulcatus tick, 1.9% of D.nuttalli tick were found and infection rate of tick was Ixodes
persulcatus-6.97%, Dermacentor nuttalli-5.2%. Seroprevalence of TBE was 25±12.1 among
population.
In forest-steppe range, 40% of TBE cases and incidence was 0.56 per 10000 population. 43.6% of
I.persulcatus tick, 44.3% of D.nuttalli, 24.4% of D.silvarum tick tick were found and infection rate of
tick was Ixodes persulcatus-3.08%, D.silvarum-1.56% and D.nuttalli-1.56%. Seroprevalence of TBE
was 14.5±11 among population.
In steppe range, 0.7% of TBE cases and incidence was 0.12 per 10000 population. 62.2% of
D.silvarum tick, 23.9% of D.nuttalli tick were found and infection rate of tick was D.nuttalli-2.81% and
D.silvarum-1.2%. Seroprevalence of TBE was 16.3±6.5 among population.
In other range including steppe-desert, gobi and high mountain, 2.8% of TBE cases and incidence
was 0.1-0.27 per 10000 population. 62.2% of D.silvarum tick, 47.6% of D.nuttalli tick were found and
infection rate of tick was D.nuttalli-0.84%. Seroprevalence of TBE was 2.5-13.1 among population.
Conclusion
Natural foci of tick-borne encephalitis have been registered in all landscape ranges of Mongolia and
higher risk area of those ranges were forest-taiga and forest-steppe.
Dermacentor silvarum, Dermacentor nuttalli tick becoming dominant vector of TBE in steppe range.