1.Correlation between serum parathyroid hormone, 25-hydrohyvitamin D and bone mass density
Ujin Sh ; Arigbukh E ; Delgerekh B ; Munkhzol M ; Nomundari B ; Uuriintuya Sh ; Erdenekhuu N ; Lkhagvasuren Ts ; Odkhuu E
Innovation 2016;10(2):38-41
Osteoporosis is a disease in which the density of bone is decreased with consequent increase in bone fragility and susceptibility to fracture risk. Vitamin D deficiency may cause secondary hyperparathyroidism and low bone mineral density. Our study was aimed to assess relation between vitamin D status and parathyroid hormone and bone density in adults.
Relatively healthy 369 participants aged between 20-60 were randomly selected from Ulaanbaatar city. Specially designed questionnaire was used in the survey. Bone mass density was diagnosed according to the WHO criteria by the T-score. Respondents serum calcium and phosphorus levels were described by the fully automated analyzer (Cobas Integra 2800, Germany). Serum parathyroid hormone and 25-hydroxivitamin D levels were described by using ELISA kit (Eucardio Laboratory, Inc. USA) at the Molecular biology laboratory of MNUMS.The statistical result was analyzed by SPSS 21 program.
The subjects mean age was 47.61±12.92, with a range of 20-83. The mean T-score was -0.60±2.17. Our study showed that negative correlation between bone mass density values at parathyroid hormone (r=-0.58, p<0.05), 25-hydroxyvitamin D (r=-0.48, p<0.05) and serum calcium (r=-0.21, p<0.05).
Our study showed increased serum parathyroid hormone led the releasing calcium from bone and decreasing bone mass density.
2. Correlation between serum parathyroid hormone, 25-hydrohyvitamin D and bone mass density
Ujin SH ; Arigbukh E ; Delgerekh B ; Munkhzol M ; Nomundari B ; Uuriintuya SH ; Erdenekhuu N ; Lkhagvasuren TS ; Odkhuu E
Innovation 2016;10(2):38-41
Osteoporosis is a disease in which the density of bone is decreased with consequent increase in bone fragility and susceptibility to fracture risk. Vitamin D deficiency may cause secondary hyperparathyroidism and low bone mineral density. Our study was aimed to assess relation between vitamin D status and parathyroid hormone and bone density in adults.Relatively healthy 369 participants aged between 20-60 were randomly selected from Ulaanbaatar city. Specially designed questionnaire was used in the survey. Bone mass density was diagnosed according to the WHO criteria by the T-score. Respondents serum calcium and phosphorus levels were described by the fully automated analyzer (Cobas Integra 2800, Germany). Serum parathyroid hormone and 25-hydroxivitamin D levels were described by using ELISA kit (Eucardio Laboratory, Inc. USA) at the Molecular biology laboratory of MNUMS.The statistical result was analyzed by SPSS 21 program.The subjects mean age was 47.61±12.92, with a range of 20-83. The mean T-score was -0.60±2.17. Our study showed that negative correlation between bone mass density values at parathyroid hormone (r=-0.58, p<0.05), 25-hydroxyvitamin D (r=-0.48, p<0.05) and serum calcium (r=-0.21, p<0.05).Our study showed increased serum parathyroid hormone led the releasing calcium from bone and decreasing bone mass density.
3.Incidence and mortality of stroke in Ulaanbaatar and its last 20 years’ trend
Oyungerel B ; Chimeglham B ; Erdenechimeg Ya ; Sarantsetseg T ; Bolormaa D ; Tuguldur E ; Uuriintuya M ; Mandakhnar M ; Khandsuren B ; Punsaldulam B ; Tovuudorj A ; Baasanjav D ; Burmaajav B
Mongolian Medical Sciences 2021;197(3):64-79
Background:
Globally the incidence of stroke is not decreasing, and the deaths and disabilities
caused by stroke is increasing every year, especially in low and low-middle income countries.
Long-term trends in stroke incidence in different populations have not been well characterized, largely
as a result of the complexities associated with population-based stroke surveillance.
Having reliable data on stroke morbidity and mortality, as well as periodic identification of long-term
trends will be important information for proper prevention planning in the population, monitoring the
disease and further improving the quality of health care.
Material and Method:
A prospective cohort study has been conducted in adult citizens (972409 in
2019, 925367 in 2020) of 6 districts of Ulaanbaatar from the 1st of January, 2019 to 31st of December,
2020. All first-ever and recurrent stroke cases were included using special software, developed for
stroke registry, based on the WHO STEPS approach from participating radiology departments of state
hospitals, district hospitals, and some private hospitals. Information of stroke death was obtained
from forensic institute and state registration office of the capital city.
The trends of stroke incidence and mortality was compared to data between 1998-1999 and 2019-
2020 in UB.
Results:
The age-standardized crude incidence rate per 100.000 person-years of stroke were
209.0/100.000 (n=1934) in 2019 and 194.0/100.000 (n=1821) in 2020 among adults of UB city. The
above results were compared to 1998-1999 studies and the incidence rate declined by 94.0/100.000
in 2019-2020, whereas mortality rate increased by 10.0/100.000 in women aged 16-34. Stroke
mortality was 11.6% in 1998 and 26.5% in 1999, while in our study it was 33.87% in 2019 and 29.71%
in 2020. Although the incidence of stroke rates has decreased in 1998-1999, the mortality rate has
not decreased significantly.
Conclusion
Morbidity and mortality rates among the population of Ulaanbaatar citizen remain
highest in the world, compared to 20 years ago with overall morbidity declining but mortality has not
decreased.
In recent years, the Government of Mongolia has been focused on reducing non-communicable
diseases, but the primary and secondary prevention and control of stroke in the general population,
as well as the acquisition of knowledge attitudes, practices and access to health care still need to be
improved.
4.A population-based stroke registry in Ulaanbaatar: preliminary result
Oyungerel B ; Chimeglkham B ; Erdenechimeg Ya ; Sarantsetseg T ; Bolormaa D ; Tuguldur E ; Uuriintuya M ; Khandsuren B ; Mandakhnar M ; Baasanjav D ; Tovuudorj A ; Burmaajav B
Mongolian Medical Sciences 2020;193(3):11-21
Background:
Stroke is still one of the leading causes of morbidity and mortality worldwide. Registry-based data of
stroke are scarce in low and middle-income countries such as Mongolia. We aimed to investigate the
incidence and mortality of stroke in adult population of UB Mongolia by stroke registration method.
Material and Method:
Covering 611265 (≥15 years old) adult citizens of three districts of Ulaanbaatar, a population-based
prospective study was done from the first, January of 2019 to 31st, December of 2019. All first-ever
and recurrent stroke cases were included using special software, developed for stroke registry, based
on the WHO STEPS approach from participating radiology departments of state hospitals, district
hospitals, and family clinics. Information of stroke death was obtained from forensic institute and state
registration office of the capital city.
Results :
In a 1-year study period, 1068 (women 39.1%) stroke cases were registered in people with 60.16±13.66
years old. Stroke incidence rate was 169.81/100000 including first-ever and recurrent events. Stroke
incidence rate was higher in men and people with 80 and above years old. The ratio between IS and
ICH was 1.14:1.0. Stroke mortality was 27.1% and mortality rate was 45.94/100000. The highest rate
mortality was in ICH subtype, male population and older people.
Conclusion
We identified relatively high incidence and mortality rate of stroke in ICH indicating an urgent need for
improvement of arterial hypertension control, health education and primary prevention mainly among
men.