Introduction The use of phytochemical preparations is being promoted an supported worldwide. In order to investigate and confirm the usage of phytochemical preparations that are widely used in the traditional medicine, there is an urgent need to complete a chemical, phytochemical and clinical study for those medicinal preparations. Goal To investigate the effects of “Antitoxic preparation” on the test animal with previously developed acute hepatotoxic infection by LPS. Materials and Methods A pathology model of the acute liver infection was developed on a total of 50 Vister rats, weighing between 200 and 250 gr. The test animals were categorized info five five further groups, e.g. healthy, control, comparison and administered with 50 mg/kg and 100 mg/kg of “Antitoxic preparation”. The preparation for each group was individually and orally administeredfor a period of ten days. On day 11, 2nd, 3rd, 4th and 5th groups were administered 5 μg of LPS and 300 mg/kg of GaIN calculated in 2 ml of physiogial solution was injected in the abdomed of the test animal. After 8 hours, AST, ALT, cholesterol, triglycerides, level of MDA, cytokine levels such as TNF-α, IL-1β, IL-6, IL-10 contained in the blood plasma of test animals were analysed. Results A comparison between measurement of “Antitoxic preparation” group and control group has indicated that the AST was 24.9-30.8%, ALT 23.8-27.6%, Poenzyme activation was reduced by 29.1-32.6%, of cholesterol by 13.2-19.9%, of tryglyceride 23.4-30.5%, MDA in plasma 8.8-20.9%, MDA in urine 11.3- 22.9%, also reduction of TNF-α in plasma by 17.5-27.3% and IL-1β17.7-19.8% respectively. Also, it was determined that the cytokines activating the acute liver infection (TNF-α, IL-1β, IL-10) were impacted after administering the preparation and infection process was suppressed. Conclusions: 1. The pathological model for chronic toxic liver infection developed on the test animal indicated that “Antitoxic preparation” had a reducing effect on cholesterol, tryglycerides, inhibitory effect on activation of fat oxidation, choleretic, antioxidant, reducing effect on ALT, AST activation, reducing the destruction of liver cells and followed by hepatoprotective action. 2. “Antitoxic preparation” was effective in impacting the cytokines (TNF-α, IL-1β, IL-10) that activate the acute liver infection and also suppressing effect on infection process.

Abstracts Traditional drug Lider-5 traditional medicine, rheumatism and arthritis disease which has been used experimental animals we created arthritis disease antioxidant system of the Lider-5 studied the impact of the loss. As a result of the research that you created via a test animal collagen II arthritis pathological articular tissues and blood plasma contained malondialidyegid In addition to reducing the antioxidant Glutathione is provided a system of the body, including supyeroksidismutaza enzymes to increase the amount of influence. As you can see in the traditional drug Lider-5 disorders antioxidant system, loss prevention, and treatment is effective, the effects of its ingredients contained Tinospora sinensis, Gentiana decumbens, such as antioxidant effect might be associated with key plant attendant substances.

Introduction: We began treatment of multi drug resistant tuberculosis first from 2003. At that time there was a 1960 cases and most of the cases were from Ulaanbaatar, Darkhan, Selenge, Tuv, Dornod provinces. From all the cases only 62% or 1058 cases were included in treatment. From that 336 patient or 19% deceased, 296 patient or 18% didn’t get a treatment. We did this study because there were never done any research or study of surgical treatment of multi drug resistant tuberculosis in Mongolia. Materials and Methods: We studied cases of patients who undergone lobectomy, since 2007. There were 48 cases of 46 patients, 2 patients surgery were done on both sides. Respondents aged between 14- 45, 25 male (52%), 23 female (48%), all patients got a first - line anti-tuberculosis treatment, such as cat-1, cat-1+cat-2 and 10 variants of these drugs. It was done based on sputum culture test results of NCCD TB surveillance and research department’s laboratory. Results: From the all patients only 77.08% had undergone surgery within the first 3 years. 92% patients were diagnosed with multi drug resistance TB only with the sputum and sputum culture test results, and the rest of the patients were diagnosed using a tissue analyses on the above tests. It was revealed that HR resistant -91.66%, HR+(Z,E,S) -3 drugs resistant -18.78%, HR+(ZSE)-4 or 5 drugs resistant. In the patients TB lesion locations was on the right upper lobe 54%, left upper lobe 31%, on a both upper lobes 85%, cavernous fibrosis tubercles 60%, combined TB lesions 77%, tubercles 21%.87.5% of total patients received a multi - drug resistant TB treatment between 7 - 24 months prior surgery. All 48 patients had a totally 69 surgeries. Surgeries included 9% pneumonectomy, 28% lobectomy, 30% Wedge resection, 23% pleurectomy decortication, 7% Wedge resection on both sides, one bilobectomy. There were no complications during the surgery but 5 of patients had an empyema after surgery. No fatal cases.Three patients out of 5 who had a surgery due to pulmonary hemorrhage developed an empyema after surgery. Drainage tubes were taken after the surgery within 2-3 months.Therewere no complication and escalations in the patients who received a surgical treatment, after the surgery from 6 months to 5 years. Conclusion: In study it shows that surgical treatment is effective to do after 6 months of anti-tuberculosis drug treatment in multi -drug resistant TB patients.Also it shows that combining of medical and surgical treatment is healing up to 98% in the patients who were rightly chosen according to surgical indications.This research result shows that in our country multi - drug resistant TB surgical treatment complication is only 10.41%, which is below in the other countries who have same anti-tuberculosis drug treatment.

Essential oils have evoked interest as sources of natural products, which their potential uses an alternative remedies for the treatment of many infectious disease and to restore healing mouth sores or kill oral bacteria. Gum disease is one of the major factor for systemic disease, which to recommend the latest study of world medical scientist. This study aimed to evaluate the anti-inflammatory activity and wound healing effect of the GINGITA® natural essential oils mouth wash in rats. Treatment was by topical application of the GINGITA® natural essential oils mouth wash onto wound surface for 21 days. Wistar rats divided into 2 groups of 15 animals each and anesthesia was administered. The dorsal area of skin of the each rats was shaved and clipped fully-thickness 10x10mm skin wound was made. The test group was treated with GINGITA® natural essential oils mouth wash, which control group untreated. A better healing pattern was observed in rats treated with GINGITA® natural essential oils mouth wash compared with the control group. There was a significant reduction in wound length and closure rats was faster treated by GINGITA® natural essential oils mouth wash compared with control group. Immunohistochemical analysis demonstrated that an increase of epithelial cells in wound lesions treated with GINGITA® natural essential oils mouth wash wish as compared untreated control group. Conclusions: The present study revealed that GINGITA® natural essential oils mouth wash may be effective in stimulating the enclosure of wounds in sort period time.

To explore the characteristics of this Lonicera Altaica, the author and her colleagues have been involved in the isolation and structure elucidation on this plant. During the course of this work, we were studied the plant was using by X-ray fl uorescence method at the institute of Physics and Technology of the Mongolian Academy of Sciences (MAS). Based on the results of multiemelent analyses, it was evident that potassium (23227 ppm) was found mainly in the plant and Se (0.34 ppm) preferably in the straw. In this study, the fatty acid composition plant was investigated. The fatty acid profi le analysis of the oil was also carried out by Gas Liquid Chromatography. The oil has three main fatty acids: palmitic, oleic and linoleic acids, linoleic acid being the most abundant. The plant content of the oil showed that 97.75% is unsaturated. It`s high content of linoleic acid is of particular interest especially in the fi ght against antioxidant and atherosclerosis. From the result of the study it was determined the preparation has no toxicity. This preparation has an anti infl ammatory and diuretic activity comparing with the control group. In this study, the protective effect preparation from Lonicera Altaica on liver infl ammation and fi brosis induced by carbon tetrachloride (CCl4) has been investigated in rats. Preparation from Lonicera Altaica signifi cantly suppressed CCI4-induced hepatic necrosis and infl ammation, as determined by the serum enzymatic activities of alanine and aspartate aminotransferase and serum alkaline phosphatase levels. In the histopathological study we carried out liver tissues from each rat were dissected; fi xed in 10 % neutralbuffered formalin. Microscopic examination was conducted on four m thick H. & E. stained sections from paraffi nembedded specimens. Treatment with preparation from Lonicera Altaica attenuated the necro-infl ammation and fi brogenesis in the CCI4-induced hepatic fi brosis, and thus it might be effective as a therapeutic anti-fi brotic agent.

Introduction: We began treatment ofmulti drug resistant tuberculosis first from2003. At that time there was a 1960 cases andmost of the cases were from Ulaanbaatar,Darkhan, Selenge, Tuv, Dornod provinces.From all the cases only 62% or 1058 caseswere included in treatment. From that 336patient or 19% deceased, 296 patient or 18%didn’t get a treatment. We did this studybecause there were never done any researchor study of surgical treatment of multi drugresistant tuberculosis in Mongolia.Materials and Methods: We studiedcases of patients who undergone lobectomy,since 2007. There were 48 cases of 46patients, 2 patients surgery were done onboth sides. Respondents aged between 14-45, 25 male (52%), 23 female (48%), allpatients got a first - line anti-tuberculosistreatment, such as cat-1, cat-1+cat-2 and 10variants of these drugs. It was done basedon sputum culture test results of NCCDTB surveillance and research department’slaboratory.Results: From the all patients only77.08% had undergone surgery within thefirst 3 years. 92% patients were diagnosedwith multi drug resistance TB only with thesputum and sputum culture test results, andthe rest of the patients were diagnosedusing a tissue analyses on the above tests.It was revealed that HR resistant -91.66%,HR+(Z,E,S) -3 drugs resistant -18.78%,HR+(ZSE)-4 or 5 drugs resistant. In thepatients TB lesion locations was on the rightupper lobe 54%, left upper lobe 31%, ona both upper lobes 85%, cavernous fibrosistubercles 60%, combined TB lesions 77%,tubercles 21%.87.5% of total patientsreceived a multi - drug resistant TB treatmentbetween 7 - 24 months prior surgery.All 48 patients had a totally 69 surgeries.Surgeries included 9% pneumonectomy,28% lobectomy, 30% Wedge resection,23% pleurectomy decortication, 7% Wedgeresection on both sides, one bilobectomy.There were no complications during thesurgery but 5 of patients had an empyemaafter surgery. No fatal cases.Three patientsout of 5 who had a surgery due to pulmonaryhemorrhage developed an empyema aftersurgery. Drainage tubes were taken afterthe surgery within 2-3 months.Therewere nocomplication and escalations in the patientswho received a surgical treatment, after thesurgery from 6 months to 5 years.Conclusion: In study it shows that surgicaltreatment is effective to do after 6 monthsof anti-tuberculosis drug treatment in multi -drug resistant TB patients.Also it shows thatcombining of medical and surgical treatmentis healing up to 98% in the patients whowere rightly chosen according to surgicalindications.This research result shows that inour country multi - drug resistant TB surgicaltreatment complication is only 10.41%,which is below in the other countries whohave same anti-tuberculosis drug treatment.

Introduction. Monos Group, Drug Research Institute is starting to investigate of Ellipin preparationfrom the mid-1990s, Ellipin has anti cancer activity in liver and several studies were investigated withscientists from Japan and China. Especially Hayashi K., Khurelbaatar L and Ambaga M were determinedanti-cancer action of the preparation and they were explained of mechanism of action, which apoptosisis seduced by influence of unsaturated fatty acids in tumor cells. However, changes of fatty acidscomposition at production stage were did not study yet. Therefore, we studied that composition of fattyacids in different term of production stage and compared of Ellipin dense substance.Materials and Methods. Samples of study were collected from production stage of “Ellipin” series130304, which was tacked in 48th hour, 120th hour of production. Each sample was dried at freezedryer “Labconco freezone12L” in Drug Research Institute. Total lipids of sample were extracted withchloroform: methanol (2: 1 v/v) according to Folch et al. Fatty acid methyl esters were analyzed usingAgilent Packard Gas Chromatograph (GC) (Model HP-6890 Agilent Packard) with mass-spectrumdetector (Model HP MSD 5973N) of Buryat State University, in Ulan-Ude.Results. Ellipin preparation is derived from bovine liver, and which is based on homogenization of bovineliver for isotonic. In this process, unsaturated fatty acids were extracted in organic solution. We studiedchanges which saturated and unsaturated fatty acids of bovine liver in process of homogenization andconsist of each fatty acid contents of end product. Results have shown that unsaturated fatty acidswere decreased by 0.4-44% till 120th hour of homogenization process. While, there were decreasedby 4-12% in the end product, although, ω-6 fatty acids were increased by 13.1-38.4%. Moreover, 25saturated fatty acids and 12 unsaturated fatty acids were detected in the Ellipin dense substance (endproduct). Hence, 67.5% of total fatty acid was saturated fatty acids, 32.5% was unsaturated fatty acidsin the Ellipin dense substance. Resent results and results of previous studies indicated that Ellipindense substance may contains saturated fatty acids on in average 50.34%, unsaturated fatty acids onin average 49,32%, respectively.Conclusion. Proportion of saturated and unsaturated fatty acids in Ellipin production was about 2:1.Saturated fatty acids and unsaturated fatty acids were found 25 and 12, respectively. Saturated fattyacids were gradually decreased and unsaturated fatty acids were slowly increased in production period,which from 48th hour of production-conveyer till end product. Moreover, content of ω-3-6-9 fatty acidswas consist 83,9-87,5% of total unsaturated fatty acid.

Goal: Research impact of “Sharkh - 2” preparation on pathological model of burning wound which was formed on experimental animal. Material and methods of the research: The experiment and research was made on pathological model of burning wound of 45 rats of Vistar breed on the basis of lab and material base of Institute of Traditional Medicine of School of Medicine, University of Medical Science, University of Medical Science in Huhhot city in Inner Mongolian Autonomous Region, National Corporation of Technology and Production of Traditional Medicine and “Sharkh - 2” preparation was applied by thin layer once on wound. Result: Wound area was decreased by 9.5% in control group in the 14th day and by 38.5% n the 28th day. In comparing group of “Sharkh - 2” with control group, there was not invisible and considerable result in the seventh day of the exerpeiment. But in “Sharkh-2” preparation, wound area decreased by 7.7% in the 14th day and by 62.9% in the 28th day. In comparison with control group, leukocyte of animals which used “Sharkh -2” preparation is less by 12.1% in the 7th day of the experiment, by 28.1% in the 14th day, 38.2% in the 28th day, sedimentation speed of red cell is less by 8.2% in the 7th day, by 12.3% in the 14th day and by 31% in the 28th day and TNF- α is not considerable I the 7th day of the experiment, 10.4% in the 14th day and by 13% in the 28th day. Conclusion: “Sharkh - 2” preparation which was extracted from raw materials of traditional medicine as Pulsatilla flavescens and Rosa aciccularis has impact to improve cure of burning wound of experimental animals.

Abstract Experimental animals created in adriamycin-induced nephropathy effects of traditional drug “Sarmisan tuulga” 1.7-3.9 times the amount of protein in the urine, serum triglycerides contained 2.3 times and 3.4 times the total amount of cholesterol reduction. And on disorders SOD increased 1.6-2 times the amount of MDA's 1.5-1.7 times, TNF-α-1.3-1.7 times the amount of IL-8 is 1.8-1.9 times the amount of reduction. According to the results of traditional drug “Sarmisan tuulga” in experimental animals acute inflammatory kidney disorder created by the generation of fat, protein exchange, antioxidant system loss, expedient gesture cytokine and podotsit kidney renal protective effect by preventing cell damage.

BACKGROUND: Assessing the customer’s satisfaction of the health care services, professional organizations suggest the special methods to study what they want and don’t want and how much can pay for the service. For this purpose, we conducted the study to determine the satisfaction of the customers of Darkhan-Uul province health care organizations in 2016, according to the international experience. The survey was conducted in the Darkhan-Uul province Health Department, in general hospitals, public and private medical institutions in 2015 and 2016 respectively. On the basis of a unified methodology according to the order of the Ministry of Health No. 13 of 2014, the survey was conducted on the basis of a special questionnaire prepared in accordance with articles 22 and 23 of the Minister of Health No. 448. The results of the consumer survey, customer satisfaction in Darhan-Uul province by 2016 were higher than in 2015, a good estimate of 1.4%, an average rating of 10.4% and below was a poor estimate of 11.8%. The survey shows the need to consider the issue of equality, which is a key issue in the field of human rights, the formulation of political environments and the regulation of their situation.