1.Relationship Between Incidence of Pseudoaldosteronism and Daily Dose of Glycyrrhiza : Review of the Literature
Naoki MANTANI ; Hiroshi OKA ; Yoshiro SAHASHI ; Ayao SUZUKI ; Motoko AYABE ; Mayumi SUZUKI ; Hiroshi KAMIYAMA ; Uruu OSADA ; Yoko KIMURA ; Takashi ITO
Kampo Medicine 2015;66(3):197-202
Incidence of glycyrrhiza-induced pseudoaldosteronism is not well understood. We examined relationships between pseudoaldosteronism incidence and daily glycyrrhiza dose in previous clinical studies. The incidence in patients administered glycyrrhiza 1 g/day was 1.0% (mean). The incidence with 2 g/day, 4 g/day and 6 g/day were 1.7% (mean), 3.3% and 11.1% (mean), respectively. Thus a dose-dependent trend toward pseudoaldosteronism incidence was suggested by previous literature.
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