Introduction: Wound care is a very important part of managing diabetic foot ulcers. The importance of choosing the right topical therapy for managing diabetic foot ulcers aims to help speed up the wound healing process. Aloe vera is one of the traditional natural ingredients that is often used in wound care and can maintain a moist atmosphere in wound care. So it is necessary to have a systematic review to provide comprehensive evidence regarding the topical effects of aloe vera in increasing wound healing in diabetic foot ulcers. This study aims to determine the topical effect of aloe vera in healing diabetic foot ulcers. Methods: This research is a systematic completion that will use six databases (CINAHL, Academic, PubMed, ProQuest, ScienceDirect, SpringerLink, and google scholar) to search for randomized controlled trial and Quasi-Experimental articles randomly in 2007-2022. The Systematic Review protocol used follows PRISMA as a guide in preparing insights and The Joanna Briggs Institute (JBI) Critical Appraisal Tools to assess research quality. This study will determine the effect of topical aloe vera on wound healing in diabetic foot ulcers. Discussion: The results of this study can be useful for knowing the topical effects of aloe vera for wound healing in diabetic foot ulcers. Trial Registration: This protocol has been registered on the protocol registration site for systematic review namely PROSPERO with registration number CRD42022318695.

Bilateral pleural effusion is fluid accumulation in both lungs of pleural spaces. The clinical manifestations of bilateral pleural effusion (chylothorax) caused by filariasis are so rare that they are often challenging to diagnose. This case study described a 21-year-old woman, domiciled in Sumatra, with complaints of shortness of breath and swollen legs. Radiological examination results found bilateral pleural effusion. Initially, it was suspected that the effusion was caused by tuberculosis, Systemic Lupus Erythematosus (SLE), and malignancy; however, treatments for these did not improve the patient’s condition. A Water Seal Drainage (WSD) was inserted and a chylous or chylothorax pleural effusion was obtained, and microfilaria was founded in the nocturnal blood examinations. Oxygen and nursing interventions were administered using lung expansion and postural drainage techniques, supported by education on effective coughing and deep breathing, along with the fulfillment of nutritional needs and dietary adjustments