1.Studying the relationship between Cryoglobulinemia and liver fibrosis in patients with chronic Hepatitis C virus infection
Amin-Erdene G ; Gantogtokh D ; Turmanduul Ch ; Yumchinsuren Ts ; Dolgion D ; Enkhmend Kh ; Bolor U ; Otgongerel N ; Ganchimeg D ; Tegshjargal B ; Tulgaa L ; Batbold B
Diagnosis 2024;111(4):10-19
Introduction:
Hepatitis C virus (HCV) infection has both hepatic and extrahepatic manifestations, and it is one of the leading cause of liver transplantation. There’s limited research on extrahepatic symptoms of chronic HCV in Mongolia, thus we aimed to investigate the relationship between cryoglobulinemia and it’s related factors.
Methods:
The study included 200 participants with active HCV, collecting blood samples for various tests (biochemical analysis, kidney function, and cryoglobulinemia detection). The degree of liver fibrosis was assessed using APRI and FIB4 scores, and the study evaluated other health conditions through a questionnaire. Statistical analysis was performed using SPSS-26.
Results:
Out of 200 participants, 148 checked for cryoglobulin precipitation and 89 (60.1%) were positive. There
was a statistically significant age difference between those with and without cryoglobulinemia (54.62 vs. 50.44 years). A higher percentage of participants with cryoglobulinemia had significant liver fibrosis (10.8% vs. 4.7% without). Liver fibrosis scores tended to increase with age, especially in men.
Conclusion
Liver fibrosis scores above 3.25 are associated with older age, lower platelet counts, elevated AST and ALT levels, and the presence of cryoglobulinemia. FIB4 scores were higher in men with active HCV and cryoglobulinemia.
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