Background: Healthcare works are high risk of infection through occupational exposure that contact with blood and other body fluids, including infected person, uses needles, syringes, equipment or exposures to sharp instruments. The World Health Organization (WHO) estimates, approximately 66,000 health workers are infected with the hepatitis B virus (HBV) and 200-5000 workers arc infected with human immunodeficiency virus (HIV) each year due to carelessness. HBV infection is a global health problem that remains to preventive. Hepatitis B can be prevented by vaccines that are safe, available and effective. In our country, which has a high prevalence of hepatitis B virus infection, it has been concluded that the coverage of hepatitis B vaccination and the level of immunity of health workers are insufficient. Aim: To evaluate post vaccination immunity against HBV in the staff of National center for transfusion medicine Methods: 63 workers with negative surface antigen of hepatitis B (HBsAg) and absent anamnesis of infection were selected for this study. In 2019 and 2020 all 63 workers were evaluated post vaccination immunity against HBV. Analysis done by Sysmex HSCL800 that is an automated immune assay system. Results and discussion: This center was begun to conduct the vaccination of workers from 2011. Among total 63 individuals involved in this study 53 (84.1%) were vaccinated against hepatitis B and 10 (15.9%) were not vaccinated. From the vaccinated 53 workers, 47 (88,7%) have immunized (anti-H Bs > 1 Ou/ml) but 6 (11.3%) of them were not immunized (anti-HBs <1 Ou/ml).
Therefore 1(1,9%) worker of them received just first dose, 14 (26.4%) workers were injected second dose, whereas 38 (71.7%) workers were vaccinated with third dose. The study shows that 12 (85.7%) workers after second dose and 34 (89.5%) workers after third dose were immunized. Conclutions As a result of hepatitis B vaccination, 88.7% of workers of the NCTM have had immunized against HBV. The final evaluation shows that 36 (57%) of workers had stable, 17 (27%) increased, and 10(16%) decreased level of immunization than the previous year.