1.Clinical Pharmacokinetics of Methadone
Hideya Kokubun ; Shirou Tomiyasu ; Shigeru Tanda ; Yasuhito Uezono ; Hajime Kagaya ; Tsutomu Suzuki ; Motohiro Matoba
Palliative Care Research 2014;9(4):401-411
Methadone oral tablets initially became available on the Japanese market in MAR-2013. Methadone, which has different pharmacological properties from other opioids including morphine, can cause serious adverse drug reactions such as respiratory depression and QT prolongation. One of the causes of these reactions is its extremely complex pharmacokinetics. Methadone is mostly metabolized in the liver, with a variety of metabolic enzymes, including cytochrome P450 (CYP) 3A4, CYP2B6, and CYP2D6, being involved. The characteristics of methadone include self-induction of metabolism, delayed excretion due to alkaline urine, and an extremely long half-life requiring a long time to achieve a steady state. Without a full understanding of its complex pharmacokinetics, the blood concentration of methadone is not maintained at a constant level, and serious adverse events could happen due to an unexpected increase in its blood concentration. Herein, for safe clinical use by physicians and pharmacists, we summarize the pharmacokinetics of methadone.
2.Mitral Valve Aneurysm Complicated with Aortic Regurgitation Due to Infective Endcarditis.
Tsutomu Kawamura ; Tomoe Katoh ; Yasuhiko Takagi ; Mamoru Kanazawa ; Haruhiko Okada ; Kazuhiro Suzuki ; Hidetoshi Tsuboi ; Masaki Miyamoto ; Kensuke Esato
Japanese Journal of Cardiovascular Surgery 1994;23(2):114-117
A 47-year-old male complaining of dyspnea and fever was admitted to our hospital and regurgitation of the aortic and mitral valves with mitral valve aneurysm due to infective endcarditis was diagnosed. The non-coronary and the right coronary cusps of the aortic valve had amount of vegetations, and also the anterior leaflet of the mitral valve had an aneurysm with vegetations. Both aortic and mitral valve replacement were performed. The postoperative clinical course was uneventful.
3.Primary Cardiac Leiomyosarcoma Originating from the Right Atrium.
Takao Suzuki ; Morito Kato ; Shinichi Oki ; Yasuhiro Tezuka ; Hiroaki Konishi ; Tsutomu Saito ; Osamu Kamisawa ; Yoshio Misawa ; Katsuo Fuse
Japanese Journal of Cardiovascular Surgery 2001;30(3):140-142
Primary malignant cardiac tumors are extremely rare. Among these, leiomyosarcoma are particularly exceptional and only about 20 surgically treated cases have been extensively described. We describe a case of right atrial leiomyosarcoma which was accidentally found by computed tomography. The tumor was surgically resected under extracorporeal circulation. Two months later the patient had cerebral hemorrhage due to a brain metastasis, which almost completely disappeared after irradiation. There was no other evidence of recurrence for 12 months after operation.
4.An Evaluation of an Introductory Course in Medicine and an "Early Exposure" Program at Akita University after the First Year Trial.
Akio KOIZUMI ; Takeshi SHOZAWA ; Masahiro SUZUKI ; Kiyoshi TOGAWA ; Yasuo HISHIKAWA ; Tsutomu WATANUKI ; Masayoshi KURATA ; Toru HARYU ; Kenro YAMAMOTO
Medical Education 1992;23(1):15-22
6.Parasitology/medical zoology pointing toward medical education remodeling
Yuzo TAKAHASHI ; Yuzaburo OKU ; Takashi AOKI ; Nobuaki AKAO ; Junko SHIMADA ; Mamoru SUZUKI ; Hiroyuki MATSUOKA ; Naoki ARIZONO ; Takafumi TSUBOI ; Tamotsu KANAZAWA ; Katsuyuki YUI ; Tsutomu TAKEUCHI
Medical Education 2010;41(1):17-21
9.Report of the Enquete about Continuing Medical Education to District Medical Associations
Tsutomu IWABUCHI ; Hiroshi KIKUCHI ; Shinichiro IZUMI ; Toru ITOH ; Kenichi UEMURA ; Kenichi KOBAYASHI ; Michio OGASAWARA ; Shoichi SUZUKI ; Arito TORII ; Masahiko HATAO ; Shigeru HAYASHI ; Masateru FUJISAWA ; Yoshiji YAMANE
Medical Education 1984;15(2):74-78