1.Evaluation of intra-Aortic-aneurysmal thrombotic-activity by 111In-labeled-platelet scintigraphy.
Hiroshi SUDO ; Shuuzou MOTOYASU ; Tsuneyuki NAGAE ; Masaki KONISHI ; Shin ISHIMARU ; Kinichi FURUKAWA
Japanese Journal of Cardiovascular Surgery 1991;20(4):643-650
Massive thrombi are sometimes present in aortic aneurysms, which cause severe complication such as distal arterial thromboembolism, and greatly influence the prognosis. Such thrombi can be easily detected by CT scan and ultrasound. However these imaging techniques can only demonstrate the presence of thrombi, and are not able to indicate these activity. We performed 111In-labeled-platelet scintigraphy (platelet scinti.) in 27 cases of aortic aneurysms (13 true aneurysms and 14 dissecting aneurysms) and 13 postoperative cases of dissecting aneurysms, and compared the findings of CT scan. In some cases, the findings of platelet scinti. were markedly different from the findings CT scan. And our results suggested that the radioisotope deposit revealed by platelet scinti. was reflected thrombotic activity. In one case of dissecting aneurysm, marked RI deposit was revealed by platelet scinti., and subsequently the false lumen was occluded. One postoperative case of dissecting aneurysm showed marked RI deposit and, distal arterial thromboembolism developed. 111In-labeled-platelet scintigraphy is thought to be useful to estimate thrombotic activity in aortic aneurysm, and to predict complications and the prognosis.
2.EFFECTS OF BICYCLE ERGOMETER EXERCISE AND PGE1 INJECTION FOR PATIENTS WITH INTERMITTENT CLAUDICATION
NORIO MURASE ; SHIRO ICHIMURA ; MIKA MORI ; KIYOSHI SHIROISHI ; KAORI MITSUOKA ; RYOTARO KIME ; TAKUYA OSADA ; TSUNEYUKI NAGAE ; SHIN ISHIMARU ; TOSHIHITO KATSUMURA
Japanese Journal of Physical Fitness and Sports Medicine 2006;55(Supplement):S119-S124
The purpose of this study was to clarify the effects of bicycle ergometer training and prostaglandin E1 (PGE1) for patients with intermittent claudication. Subjects were divided into four groups : the medication group (M), the PGE1 group (P), the exercise group (E) and the PGE1 and exercise group (PE). The P group was injected with 10μg of PGE1, the E group performed bicycle ergometer exercise 3 times a week for 6 weeks, and the PE group was injected with PGE1 and performed exercises. The maximal walking distance (MWD) was evaluated by a treadmill test. Muscle oxygenation level was measured by near-infrared spectroscopy and recovery half time (T1/2) was calculated. MWD was significantly improved for P (142%), E (216%) and PE (240%) groups. T1/2 was significantly improved in the E and PE groups. This study indicates that improvement of MWD was a result of development of muscle perfusion in lower limbs and PGE1 injection may support exercise therapy.
3.Bicycle Ergometer Exercise prolonged walking distance for Patients with Intermittent Claudication — Evaluated by Near-infrared Spectroscopy
Norio Murase ; Shiro Ichimura ; Aya Kitahara ; Takeshi Nagasawa ; Chihoko Ueda ; Toshiyuki Homma ; Ryotaro Kime ; Takuya Osada ; Tsuneyuki Nagae ; Shin Ishimaru ; Toshihito Katsumura
Japanese Journal of Physical Fitness and Sports Medicine 2005;54(1):75-75