Introduction Along with the changes occurred in nutrition, climate over the years, the prevalence of blood disorder related diseases, such as Аllergic purpura (AP), Idiopathic thrombocytopenic purpura (ITP) is increasing. The current perspective of health service is focused on the treatment of AP and ITP by using combined therapeutic methods of modern and Mongolian medical approach. Mongolian traditional medicine has an advantage of reducing complications in reducing the recovery duration and also preventing from re-occurrence. Consequently, there is a need for investigation of formulating clinically effective preparation that complies with pharmaceutical standards. Objective The objective of this study was to develop the technology to obtain Tsusan Bolor capsules and establish its some quality criteria indicators. Materials and Methods The medicinal raw materials Gardenia Jasminoides Ellis, Rubia cordiofolia L, Picrorhiza serophulariflora Pennell, Arnebia guttatа, Crocus sativus, L, Pulvis Cornus Bubali and Artificial Bezoar were provided by Traditional medicine factory of the Inner Mongolian University for Nationalities, PRC. The L9(34) experiment test was used to obtain the extracts from crude medicinal plants and TLC, HPLS and pharmacopeias methods were used for the establishing quality criteria indicators of the capsules. Results Within the technological study the appropriate methods to obtain alcohol and water extracts from the medicinal raw materials and the technological scheme to obtain Tsusan bolor capsules were developed. As the results of quality criteria investigation indicated, the total content of gardenia glycoside is 1.71±0.02 mg, water content- 6.25±0.1%, heavy metal and arsenic content less than 10 μg/g and 2μg/g and disintegration time of the capsules is 20±3.

Introduction: In pharmaceutical industry there are some possibilities of contamination and cross contamination because of improper cleaning of equipment, apparatus, processing area or the starting material, this can lead to severe hazards, therefore in pharmaceutical industry could not afford any contamination as well as cross contamination. This can be minimized by proper cleaning of equipment, apparatus as well as the processing area. The cleaning validation is a documented process that proves the effectiveness and quality prospective. Manufacturing of Diclofenac sodium (DICLOMON) retard tablets and utilizing common facility, where diclofenac sodium could be possible cross contaminant. The present study was carried out to validate the cleaning activity from both regulatory and quality prospective. Methods: All chemicals and reagents used for cleaning validation were analytical grade and used LC-20AT Shimadzu HPLC. Traditional methods were used for microbiological analysis. The instruments in the common facility were cleaned with purified water after production of Diclofenac sodium retard tablets 100mg. Validation of cleaning activity was carried out by visual inspection, swab sampling for chemical residue and similarly swab sampling for Microbiological analysis. Conclusion The cleaning validation studies of Diclofenac sodium retard tablets 100mg was observed by visual inspection, swab sampling for chemical residue and similarly swab sampling for microbiological analysis. The result revealed that (1) There were no visual residues on the equipment (2) Chemical residues were below acceptance criteria (3) Total aerobic microbial count(TAMC) were below acceptance criteria (4) Total combined molds and yeast count was Nil and (5) Pathogens were absent Upon the compiled data, it was concluded that the train of equipment in tablet manufacturing block is completed, and the results were found to be satisfactory and there is no cross contamination of Diclofenac sodium to next product.

Abstract In pharmaceutical industry there are some possibilities of contamination and cross contamination because of improper cleaning of equipment, apparatus, processing area or the starting material, this can lead to severe hazards, therefore in pharmaceutical industry we could not afford any contamination as well as cross contamination. This can be minimized by proper cleaning of equipment, apparatus as well as the processing area. Prevention of cross contamination is one of the most significant conditions of Good Manufacturing Practices for drugs. This is especially topical for a multipurpose (shared) manufacture where several medicinal products, including drugs of different pharmacotherapeutic groups, are produced using the same facilities (manufacturing areas, workrooms, and equipment). The industry is able to achieve these key goals with the help of implementation of GMP. Therefore, a perfect cleaning method is required for avoiding the possibilities of contamination and cross contamination, for this a validated program is required, this program is known as cleaning validation. “Cleaning validation is documented evidence which assure that cleaning of equipment, piece of equipment or system will obtain pre-determined and acceptable limits”.

Abstract: Ngo mtshar dga’ ston gter mdzod” by gelong (Fully ordained monk, Tib. དགེ་སློང་) Choijamts is one of the important medical books of traditional medicine. From this book, we found the Srog dzin-5 prescription and the purpose of the study is to determine acute and chronic toxicity of the prescription, and to identify its effect on animal models of depressive disorders. Methods:
1. The study was conducted using quantitative research method by experimental research model.
2. Determination of acute and chronic toxicity.
3. Chronic Unpredictable Mild Stress (CUMS) Procedure. Conclusion
1. Srog dzin-5 prescription (LD₅₀ = 25.8 (24-29) g/kg) has been shown to be non-toxic according to the generally accepted classification of K.Sidorov and B.Berezovskaya. When conducting histological studies, it was found that the surface of the liver, kidneys and adrenals is smooth. Color, shape and size of organs are normal.
2. In the model of chronic stress-induced depression, the Srog dzin-5 prescription increases physical activity, reduce tears, prevent anxiety and weight loss.

Abstract: There is a growing need for a systematic study of the use of medicines prepared from herbal, animal, and mineral raw materials in traditional Mongolian medicine to a new level. Based on traditional medicine technology and use, the study identified the most suitable modern medicinal ingredients for the human body, namely a medicine that can be used for depression in the ancient scripture, “Ngo mtshar dga’ ston gter mdzod” by Gelen Choijamts and further practical application is imperative. Purpose: To study the effects of Srog dzin-5 prescription on pathogenesis model of acute stress and animal models of depressive disor- ders. Conclusion
1. In the pathogenesis model of acute stress disorder caused by restricted mobility, Srog dzin-5 prescription prevents stress-induced thymic involution and enlargement of adrenal glands.
2. In the pathogenesis model of ethanol-induced depression, Srog dzin-5 prescription increased physical activity, reduced despair, and prevented anxiety according to behavioral assessment.

Introduction: It is important to standardize a tincture prepared from the herb and root of Paeonia anomala L, which is widely used as a sedative in traditional medicine, based on the results of the studies its chemical composition, biological and pharmacological activities. Moreover, there is a need to carry out a quantitative stability testing in order to establish the ability to maintain quality under certain storage condition, shelf-life and to develop suitable packaging information. Materials and methods: Standardization parameters of prepared Paeonia anomala tincture have been evaluated according to WHO guidelines for the determination of crude drug material, plant preparations and finished products technical parameters, along with the Mongolian National Pharmacopoeian (MNP) and Russian XIV Pharmacopoeian methods for tincture. The color of a tincture, dry residue, special density, alcohol content, and microbiological content were determined according to the methods described in MNP. A qualitative analysis of biological active constituents has been evaluated by thin-layer chromatography, the total phenolic compounds were determined by the reaction with Folin Chicalteu reagent and total monoterpene glycosides by the reaction with hydroxylamine in alkaline solution and ferric (III) chloride following spectrophotometric examination, respectively.
The stability testing study was performed according to the “General requirements for the stability testing study of drug-active compounds” MNS-6439-2014 using the real-time methods for the standardization parameters of the tincture. Conclusions The standardized parameters of tincture prepared from the herb and root of Paeonia anomala L. were approved by the National Reference Laboratory for Food Safety analysis. Consequently, the Mongolian pharmacopoeian article on Paeonia anomala tincture was officially permitted under the number ҮФӨ-0327-2017.
The stability study of tincture was carried out according to the MNS-6439-2014 by real-time tests for 24 months which provided that the changes in tincture quality were within the permitted limits. Consequently, it can conclude that the storage condition and shelf-time of Paeonia anomala tincture are 2 years under not above 25°С.