In traditional Mongolian medicine, 18 liver disorders are counted and each of them is denominated by specific medical term. However, liver diseases described in traditional Mongolian medicine do not easily match liver diseases as specified by the western medical system. Therefore, it is important to detect active constituents in Mongolian plants which give a rational for an application in the conventional Western treatment of liver disease. Mongolian traditional medicine doesn’t indicate cancer diseases separately. Under the traditional medical term ‘liver disorder’ mentioned non-cancer and cancer diseases of liver. For this reason, medicinal plants and compounds are prescribed in common hepatobiliary ailments. The most important part of Mongolian traditional medicine is medication. Mongolian materia medica consists of plants, minerals, and animal parts or products, however, the plants have always made up the main part (about 80%) of the prescriptions. By the theory of TMM mostly young strength persons with “bile-fire” constitutions, who stayed enough time in warm dry conditions suffers from acute, “hot” quality liver disease, and there is a suitable to use a bitter tested and cool, blunt quality remedies. This principle of therapy explained what mentioned above quality plants might have an antioxidant activity; promote membrane stability and reduce cys-configurations of membrane. This interesting hypothesis was successfully studied on species of Gentiana acuta, Silibum marrianum, Salsola colina. During pharmacological study of Chiazospermum erecthum Bernh. species were identified main biological active substances such as protopine alkaloid. Within the studying of protopine alkaloid property species such as Chiazospermum erecthum Bernh Mongolian scientists interested in a bitter tested, cool, rough, blunt quality plants same with Chiazospermum, and identified high amount of protopine alkaloid in Berberis sibirica, Thalictrum, Chelidonum majus species. Further Chiazospermum erecthum L. was studied on D-galactosamine liver damage model, and determined that dry extract from aerial part of Chiazospermum erecthum L. reduced cytolytic syndromes and cholestasis, promoted the accelerated normalization of its functional condition. Lilium pumilum Delile flowers‘infusion is thought to have a protective effect on liver injures and improve the microvascular circulation disorder known as disseminated intravascular coagulation. Saussurea amara (L.) DC is widely spread medicinal plant in Mongolia and successfully used in Mongolian traditional medicine as a holeretic component. The content of biological active of compounds was examined with thin layer chromatography and apigenin was isolated and identified for the first time. Beneficial effects, such as dose dependent choleretic effects were seen with apigenin from aerial part of Saussurea amara (L.) DC in an isolated rat perfused liver model. Beside of single plant species hepatoprotective compounds were studied by Mongolian scientists. Prof. L.Myagmar (1974) determined that total amount of flavonoid from Lomatogonum caranthiacum wulfen at Br. and Achillea asiatica L.species increaced bile secretion of experimental animals and demonstrated hepatoprotective activity. “Barbad-10” is potent hepatoprotective compound. Traditional compound “Degd-3” used as a remedy for bloodletting preparation influenced on immunosuppressive cells positive location. Also were determined antioxidant and choleretic activity of total flavonoids from Bupleurum scorzonerifoilium, hepatoprotective activity of gammapyrone substances isolated from two species of Gentianaceae family: Gentiana acuta and Lomotogonium rotatum L. 11 types of flavon substances were isolated from Saxifraga hirculus L. and Lomatogonium carinthiacum Wulfen et Br. species, and was determined hepatoprotective action of Saxifraga hirculus L. In other hand, Saxifraga hirculus L. increased the biliary secretion and excretion speed, protected from toxic detergent effect of bile acid, improved detoxification effect of the liver, protected from the necrotic cell lysis, showed antioxidant and membrane stabilizing activity and these actions were compared with the standard medicines such as Legalon and Cholosasum which in some cases, above mentioned effects were higher than these drugs. Hepatoprotective action of Saxifraga hirculus L. may have been related to its contents such as compound flavonoids of the quercetin group, aglycone and bitter hyperoside. From traditional recipes of liver remedy were developed following new formulations which demonstrated hepatoprotective actions and influenced on bile secretion: “Hepamon, “Silodin”, “Saxifragen”, and “Berchessazin”.