1.Efficacy of repetitive transcranial magnetic stimulation on refractory epilepsy in Malaysia
Sherrini Bazir Ahmad ; Kheng Seang Lim ; Hui Ting Goh ; Chen Mun Wo ; SiewYong Low ; Chong Tin Tan
Neurology Asia 2016;21(3):225-233
Background & Objective: Modulation of cortical excitability by low frequency repetitive transcranial
magnetic stimulation (rTMS) has demonstrated therapeutic use in epilepsy. This study aimed to evaluate
the efficacy of low-frequency rTMS on refractory epilepsy in a group of Malaysian subjects. Methods:
Nine patients with refractory epilepsy completed the study. All patients received 10 sessions of 1Hz
rTMS (1000 pulses per session) at 90% of resting motor threshold. Outcome measures included seizure
frequency, Symptom Checklist-90 (SCL-90), Beck Depression Inventory II (BDI II) and Quality of
Life in Epilepsy-31 (QOLIE-31). Responders were defined as having ≥ 50% seizure reduction. Results:
The mean age was 33.8 years (SD 11.7), with 4 male. Three patients had mesial temporal sclerosis
(MTS); 4 with focal cortical dysplasia (FCD) and two lesion-negative. Three patients achieved >50%
seizure reduction at 8 weeks post-treatment, with 2 of them had improvement in the number of IED.
All of the responders had FCD. The responders were younger (mean 24.7 vs. 38.3 years old), had
shorter duration of illness (mean 15.7 vs. 30.5 years) and had less frequent seizure frequency prior to
treatment (mean 5.5 vs. 10.8 attacks per week), as compared to the non-responders. Six patients had
improvement in BDI-II scores, two in QOLIE-31 and four in SCL-90 post treatment, irrespective of
seizure control. The mean scores in BDI-II improved significantly with treatment (p<0.01).
Conclusion: rTMS is a potentially promising treatment for epilepsy, esp
Transcranial Magnetic Stimulation
;
Epilepsy
2.Conduction study of facial nerve using transcranial magnetic stimulation.
Journal of the Korean Academy of Rehabilitation Medicine 1992;16(2):168-174
No abstract available.
Facial Nerve*
;
Transcranial Magnetic Stimulation*
3.High and low frequency repetitive transcranial magnetic stimulation in smoking cessation: A systematic review
Ariza Joy A. Dechavez ; Criscely L. Go
Philippine Journal of Neurology 2023;26(2):31-41
Abstract:
Repetitive Transcranial Magnetic Stimulation is a non-invasive brain stimulation process
popularly used to treat psychiatric disorders. Multiple evidence shows effectiveness of rTMS in
treating addiction, particularly in tobacco or cigarette users. This study consisted of review of
current published literatures on repetitive transcranial magnetic stimulation following
predefined eligibility criteria. The studies included evaluated at least one of the epidemiological
parameters: (i) the meaning of repetitive transcranial magnetic stimulation (ii) Effectiveness of
the Repetitive Transcranial Magnetic Simulation Over Behavioral therapy (iii) rTMS-associated
adverse events among tobacco users
Methodology:
We included published studies discussing rTMS in smoking cessation which examined if these
interventions were effective and identified whether it has a severe negative effect on the
patients.
A total of 104 related studies were identified through database searches (Pubmed,
Elsevier, Cochrane). Of which, 53 duplicate studies were removed. Five studies were then
excluded with more than 10 years in publication. A total of 28 papers were then included in the
study.
Conclusion
We conclude that rTMS is more effective in treating addiction in terms of smoking compared to
behavioral therapy and rTMS affects triggered desired circuit which may be crucial among
tobacco users. Individual neuronal excitability in the specific region’s subsequent induction may
impact the therapeutic outcomes.
With this, the high-frequency rTMS sequentially applied to
the left superior medial frontal cortex and dorsolateral prefrontal cortex may be an effective tool
for improving the cessation rate.
Transcranial Magnetic Stimulation
;
Smoking Cessation
4.Short Term Effects of Repetitive Transcranial Magnetic Stimulation in Patients with Catastrophic Intractable Tinnitus: Preliminary Report.
Ho Yun LEE ; Seung Don YOO ; Eun Woong RYU ; Jae Yong BYUN ; Seung Geun YEO ; Moon Suh PARK
Clinical and Experimental Otorhinolaryngology 2013;6(2):63-67
OBJECTIVES: The short-term effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) in the patients with catastrophic and intractable tinnitus were investigated. METHODS: Fifteen participants were recruited among patients with catastrophic intractable tinnitus to receive 1 Hz rTMS treatment. Tinnitus severity was assessed before rTMS and directly after sham or real rTMS using the tinnitus handicap inventory (THI) and visual analog scale (VAS). RESULTS: There was no statistical difference in the THI score before and after sham stimulation. However, after 5 replications of real rTMS there was statistically significant reduction in THI score. Eight patients showed a decrease of more than 10 in THI score. Patients who showed a vast change in THI score after rTMS also showed a large decrease in their VAS score (r=0.879, P<0.001). Duration of tinnitus and change of THI score showed statistically significant moderate negative correlation (r=-0.637, P=0.011). But in case of VAS, there was no significant difference between VAS and duration of tinnitus. CONCLUSION: Among total 15 patients with catastrophic intractable chronic tinnitus, eight patients showed some improvement in symptoms after 1 Hz rTMS. rTMS can be considered management modality for intractable tinnitus even with distress as severe as catastrophic stage.
Humans
;
Salicylamides
;
Tinnitus
;
Transcranial Magnetic Stimulation
5.Clinical Implications of Transcranial Magnetic Stimulation in Alzheimer's Dementia.
Dong Woo KANG ; Soo Hyun JOO ; Chang Uk LEE
Journal of Korean Neuropsychiatric Association 2016;55(1):1-11
The objective is this study is to provide a comprehensive understanding of the clinical implication of transcranial magnetic stimulation (TMS) in Alzheimer's dementia (AD). We collected studies using TMS in patients with AD and reviewed 41 identified articles. Thirty five articles were about measures of cortical reactivity, plasticity, connectivity, and six articles were about the enhancement of cognitive function in AD. Reduced short-latency afferent inhibition and resting motor threshold which reflect cholinergic dysfunction and enhanced cortical excitability respectively are consistent findings of altered cortical reactivity in AD. In addition, cortical plasticity and connectivity have shown impaired results in AD compared with healthy controls. Repetitively delivered TMS can improve several domains of cognitive function impaired in AD. Although the evidence is still preliminary, TMS has a clinical implication as a diagnostic and therapeutic method in AD. Thorough investigation of factors that can affect the results of TMS and further studies to clarify the results are needed.
Dementia*
;
Humans
;
Plastics
;
Transcranial Magnetic Stimulation*
6.Early Augmentation Response with Low-frequency Repetitive Transcranial Magnetic Stimulation in Treatment Resistant Depression.
Jyoti SINGH ; Amit SINGH ; Sujita Kumar KAR ; Erika PAHUJA
Clinical Psychopharmacology and Neuroscience 2017;15(2):197-198
No abstract available.
Depressive Disorder, Treatment-Resistant*
;
Transcranial Magnetic Stimulation*
7.Zonisamide Changes Unilateral Cortical Excitability in Focal Epilepsy Patients.
Eun Yeon JOO ; Hye Jung KIM ; Yang Hee LIM ; Ki Hwan JI ; Seung Bong HONG
Journal of Clinical Neurology 2010;6(4):189-195
BACKGROUND AND PURPOSE: To evaluate changes in cortical excitability induced by zonisamide (ZNS) in focal epilepsy patients. METHODS: Twenty-four drug-nasmall yi, Ukrainianve focal epilepsy patients (15 males; overall mean age 29.8 years) were enrolled. The transcranial magnetic stimulation parameters obtained using two Magstim 200 stimulators were the resting motor threshold, amplitude of the motor-evoked potential (MEP), cortical silent period, short intracortical inhibition, and intracortical facilitation. These five transcranial magnetic stimulation parameters were measured before and after ZNS, and the findings were compared. RESULTS: All 24 patients were treated with ZNS monotherapy (200-300 mg/day) for 8-12 weeks. After ZNS, MEP amplitudes decreased (-36.9%) significantly in epileptic hemispheres (paired t-test with Bonferroni's correction for multiple comparisons, p<0.05), whereas the mean resting motor threshold, cortical silent period, short intracortical inhibition, and intracortical facilitation were unchanged (p>0.05). ZNS did not affect cortical excitability in nonepileptic hemispheres. CONCLUSIONS: These findings suggest that ZNS decreases cortical excitability only in the epileptic hemispheres of focal epilepsy patients. MEP amplitudes may be useful for evaluating ZNS-induced changes in cortical excitability.
Epilepsies, Partial
;
Humans
;
Isoxazoles
;
Transcranial Magnetic Stimulation
8.Zonisamide Changes Unilateral Cortical Excitability in Focal Epilepsy Patients.
Eun Yeon JOO ; Hye Jung KIM ; Yang Hee LIM ; Ki Hwan JI ; Seung Bong HONG
Journal of Clinical Neurology 2010;6(4):189-195
BACKGROUND AND PURPOSE: To evaluate changes in cortical excitability induced by zonisamide (ZNS) in focal epilepsy patients. METHODS: Twenty-four drug-nasmall yi, Ukrainianve focal epilepsy patients (15 males; overall mean age 29.8 years) were enrolled. The transcranial magnetic stimulation parameters obtained using two Magstim 200 stimulators were the resting motor threshold, amplitude of the motor-evoked potential (MEP), cortical silent period, short intracortical inhibition, and intracortical facilitation. These five transcranial magnetic stimulation parameters were measured before and after ZNS, and the findings were compared. RESULTS: All 24 patients were treated with ZNS monotherapy (200-300 mg/day) for 8-12 weeks. After ZNS, MEP amplitudes decreased (-36.9%) significantly in epileptic hemispheres (paired t-test with Bonferroni's correction for multiple comparisons, p<0.05), whereas the mean resting motor threshold, cortical silent period, short intracortical inhibition, and intracortical facilitation were unchanged (p>0.05). ZNS did not affect cortical excitability in nonepileptic hemispheres. CONCLUSIONS: These findings suggest that ZNS decreases cortical excitability only in the epileptic hemispheres of focal epilepsy patients. MEP amplitudes may be useful for evaluating ZNS-induced changes in cortical excitability.
Epilepsies, Partial
;
Humans
;
Isoxazoles
;
Transcranial Magnetic Stimulation
10.Repetitive transcranial magnetic stimulation: a potential therapeutic modality for chronic low back pain.
Sajad SHAFIEE ; Farshad HASANZADEH KIABI ; Misagh SHAFIZAD ; Amir EMAMI ZEYDI
The Korean Journal of Pain 2017;30(1):71-72
No abstract available.
Low Back Pain*
;
Transcranial Magnetic Stimulation*