1.Combined Therapy Using Sairei-to (TJ-114) and Camostat Mesilate for Chronic Glomerulonephritis.
Yuji AKIYAMA ; Shuji OHNO ; Toshihisa FUJIMAKI ; Satoru ODAGIRI ; Toshiyuki ASAOKA ; Masahiko TANAKA ; Teruhiko SUZUKI ; Yutaka DOHI
Kampo Medicine 1996;47(3):405-410
Twenty-two patients with chronic glomerulonephritis were treated with Sairei-to (7.5g/day), either alone or in combination with camostat mesilate (600mg/day), to determine the efficacy and adverse effects of these regimens. Although there was significant improvement in proteinuria (p<0.05) after 8 weeks of treatment with Sairei-to alone, this was not longlasting. Combination therapy resulted in sustained significant improvement (p<0.03; there were two dropouts). No adverse effects were seen with either regimen. The results suggest that combination therapy using Sairei-to and camostat mesilate may be a safe and efficacious method of treatment for patients with chronic glomerulonephritis.
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