Comparative studies were made mainly on malignant cases of cholelithiasis in 111 patients with gallstones detected in our regular chekup (group A) during the five-year period from 1985 to 1989 and 67 patients who had gallstones surgically removed together with malignancies (group B) during the same period.
The group A patients representing 4.2% of the total 2, 637 examinees were suspected to suffer from biliary obstruction and malignant tumors involving the digestive system. However, further examination found only one case of biliary tract cancer.
The group B patients account for 20.9% of the total 321 surgery cases. In 37 (55.2%) of the 67 patients, 45 legions were malignant-mostly cancer in the digestive organs. Cancer of the lower portion of the digestive tract was found in 11 patients (29.7%) of the 37. The occult blood test at hospitalization revealed that 8 patients (28.6%) in 28 were positive, and 9 were not clear. Follow-up examination showed the rate of false-positive reaction to blood test stood at 14.3%.
From the foregoing results, to detect cancer of the large intestine at an early stage in the regular medical checkup sponsored by the agricultural cooperative, the occult blood test using the stool of examines alone is not enough. It is high time to introduce endoscopic examinationinto the screening program. In view of the fact that most of the gallstone cases detected at the regular checkup were symptomless, careful followup examinations are deemed necessary with the possibleonset of gallbladder cancer and presence of malignancies in mind.