1.Myonephropathic Metabolic Syndrome after Cardiac or Aortic Surgery
Hiromichi Fujii ; Hirokazu Ohashi ; Yasushi Tsutsumi ; Takahiro Kawai ; Toshihide Tsukioka ; Masateru Onaka
Japanese Journal of Cardiovascular Surgery 2003;32(4):230-233
Myonephropathic metabolic syndrome (MNMS) is a fatal complication following open-heart or aortic surgery. We evaluated 7 cases of MNMS following cardiac or aortic surgery. The patient's ages ranged from 43 to 81 years old. Of the 7 patients, four presented with myocardial infarction, which required coronary artery bypass grafting (CABG), and three presented with acute aortic dissection. Two patients with Stanford type A underwent total arch replacement and CABG and 1 patient with Stanford type B underwent a left axillo-femoral bypass. MNMS was caused by acute arterial occlusion due to intra-aortic balloon pumping (IABP) or percutaneous cardio-pulmonary support (PCPS) in patients who experienced myocardial infarction and acute lower limb ischemia in patients who experienced aortic dissection. The ratio of MNMS caused by IABP and PCPS, and acute aortic dissection was 1.4% and 4.2%, respectively. Four patients died; 3 had undergone CABG and 1 had undergone an aortic operation 18.5h after acute dissection. Both IABP and PCPS were removed early in possible cases. Limb wash-out was performed in 1 patient, and 5 were treated with hemodiafiltration. IABP and PCPS should be introduced via a prosthetic graft if limb ischemia is noticed. MNMS should be recognized as a disastrous complication of aortic dissection, and early bypass graft or limb amputation may become the treatment of choice. We emphasize that hemodiafiltration should begin as soon as MNMS is diagnosed.
2.Association of serum BDNF concentration with high-intensity interval training
Koichiro Azuma ; Yusuke Osawa ; Shogo Tabata ; Shiori Horisawa ; Fuminori Katsukawa ; Hiroyuki Ishida ; Yuko Oguma ; Toshihide Kawai ; Shuji Oguchi ; Atsumi Ota ; Haruhito Kikuchi ; Mitsuru Murata ; Hideo Matsumoto
Japanese Journal of Physical Fitness and Sports Medicine 2015;64(2):227-232
To evaluate the association of serum BDNF concentration with high-intensity interval training, 12 healthy male volunteers, aged 28-48 years, completed 16-week high-intensity interval training (HIIT) using ergometer. Training program consisted of >90% VO2 peak for 60 sec separated by 60 sec active rest period for 8-12 sets twice weekly for 16-week. Maximal exercise tolerance tests were performed before (0-week), 4-week, and 16-week after the intervention program. VO2 peak as well as peak watt was linearly increased after 4-week (9% for both VO2 peak and peak watt) and 16-week HIIT training (15% for VO2 peak and 18% for peak watt, p<0.01). However, there was no change in serum BDNF concentration by HIIT. On the other hand, there was a positive association of serum BDNF concentration at baseline with % increase in peak watt after the intervention (ρ=0.60, p<0.05). The association between BDNF and exercise training is still unclear, and more studies are needed to clarify the above positive association.