1.Perioperative Change of Atrial Natriuretic Peptide and Brain Natriuretic Peptide in Relation to the Surgery for Abdominal Aortic Aneurysm
Yoshiharu Nishimura ; Shinichi Higashiue ; Toshifumi Mori ; Masahiro Iwahashi ; Atsutoshi Hatada
Japanese Journal of Cardiovascular Surgery 2003;32(6):333-336
Perioperative changes of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in surgically treated cases of abdominal aortic aneurysm (AAA) were investigated. A retrospective review of 34 patients of AAA who underwent operation was carried out. All patients received cardiac catheterization before the AAA operation. ANP and BNP were measured on the preoperative day, postoperative day (POD) 1 and POD 2, respectively. Twenty-two cases were complicated by ischemic heart disease (IHD). In all cases of AAA, ANP and BNP increased significantly at POD 1 and POD 2. The levels of ANP and BNP in the AAA with IHD group were significantly higher than those in the AAA without IHD group at all points. These results suggest that postoperative care for cardiac overload during the AAA operation is especially needed for patients with IHD.
2.Opioid switching to oxycodone injection using simple conversion ratio
Tsuyoshi Miyahara ; Toshifumi Kosugi ; Ayumi Nita ; Sasagu Hamada ; Atsuko Hiura ; Naomi Mori ; Yuki Hachiya ; Naomi Hirakawa ; Hidetoshi Sato ; Hisashi Matsunaga
Palliative Care Research 2014;9(4):125-130
Purpose: The simple conversion ratio of 1：1：1/50 between oxycodone injection (OXJ), morphine injection and fentanyl injection is used at Saga－Ken Medical Centre Koseikan. However, there are no studies on the validity of the simple conversion ratio. Methods: A total of 18 patients with opioid switching to OXJ using the simple conversion ratio were reviewed in this investigation. We surveyed the change in the numeric rating scale (NRS) and adverse effects before and after opioid switching. Result: The average period needed to reach a stable dose of OXJ was 0.6 days. The reasons of opioid switching to OXJ were the uncontrolled cancer pain in 11 patients, the impossibility of oral administration in 6 patients, the drowsiness in 1 patient. The average NRS decreased from 3.3 to 1.1 in 11 patients with uncontrolled cancer pain (p＝0.007). No obvious change in the NRS was observed in 6 patients with the impossibility of oral administration. In 18 patients, there was no significant difference in adverse effects before and after opioid switching. Conclusion: These results indicate that the simple conversion ratio could be safety for opioid switching between OXJ and other opioid in cancer pain treatment.
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