1.Analysis on the prevalence of hypertension in patients with Keshan disease in Fuyu County, Heilongjiang Province
Gai-gai, ZHANG ; Yue, LIU ; Tong, WANG ; Hong-qi, FENG ; Jin-feng, YU ; Xin-hua, YIN
Chinese Journal of Endemiology 2009;28(4):440-442
Objective To explore the reasons why patients with Keshan disesse complicated with hypertension and their interaction in Fuyu County, Heilongjiang Province. Methods Fifty-three patients with Keshan disease were investigated in January, April and July in 2007. Blood pressure was measured and the risk factors of hypertension were investigated. According to the diagnostic criteria of hypertension, patients were divided into hypertension group and non-hypertension group, and then the risk factors of hypertension, as well as the course of Keshan disease, were compared between the two groups. The risk factors include age, gender, family history of hypertension, salt intake in diet, smoking, drinking and obesity. Results The age of hypertension group[(57.83±8.89)years] was significantly higher than that of non-hypertension group [(51.53 ± 9.43)years, t = 2.3630, P < 0.05) ;while the course of Keshan disease in non-hypertension group [(31.63 ± 8.66)years] was notably longer than that in hypertension group [(25.08±11.41)years, t = 2.0224, P < 0.05] ;No statistically significant difference in gender, family history of hypertension, salt intake in diet, smoking, drinking and obesity was observed between the two groups(χ2 = 0.0072,0.1779,0.0029,0.1555,0.119,0.7679, all P > 0.05). Conclusions Age might be an important factor in patients with Keshan disease accompanied by hypertension, and the role of other risk factors of hypertension should not be overlooked;whether Keshan disease and hypertension can affect each other needs further investigation.
2.Vowel's Nasalance and Contact Quotient in Children with Hearing Loss
KIM Ha-kyung ; Tong GAI ; HWANG Young-jin ; Zhaoming HUANG
Chinese Journal of Rehabilitation Theory and Practice 2013;19(7):604-607
Objective To investigate the vowel's nasalance and contact quotient (CQ) in children with hearing loss. Methods 57 subjects were divided to 3 groups: profound hearing loss children with hearing aids (HA, n=19), profound hearing loss children with cochlear implant (CI, n=19) and children without hearing loss (n=19). With the help of NV and electroglottography (EGG), the subjects' nasalance and CQ were recorded when they said /a/, /æ/, /i/, /o/, /u/. Results There was no significant differences among the 3 groups on nasalance (P>0.05). There was significant difference among 5 vowels on nasalance, ranked as /u/, /o/, /æ/, /i/, and /a/ (P<0.001). There was significant difference among 3 groups on CQ, ranked as HA, normal, and CI group (P<0.001). There was significant difference on CQ among 5 vowels,ranked as /i/, /u/, /æ/, /o/, and /a/ (P<0.001). Conclusion The voice and resonance should be assessed before speech therapy, which the speech therapy starts from the most correct vowel for children with profound hearing loss.
3.Evaluation on self-treatment of patients with chronic Keshan disease in Fuyu County, Heilongjiang Province
Gai-gai, ZHANG ; Yue, LIU ; Xin-hua, YIN ; Tong, WANG ; Zhong-yu, MA ; Hong-qi, FENG ; Hong, LIU ; Jin-feng, YU ; Jun-rui, PEI ; Zi-dan, GUO
Chinese Journal of Endemiology 2008;27(5):566-569
Objective To evaluate the self-treatment effectiveness on patients with ehwnic Keshan disease.Methods Twenty patients with chronic Keshan disease were selected from individuals with Keshan disease in Fuyu County,Heilongjiang Province.They were trained three times every three months of self management including pathogenetic condition education,general guidance,drug therapy,and they also taught how to adiust the doBe of drug according to their illness.Major symptom score,heart rate(HR),ultrasoundcardiogram (UCG)index and cardiac functional grading of these patients at basehne,after 3 months and 6 months of treatment were compared.Results The 20 patients rated their main symptoms score as(15.03 ±6.77)before self- treatrnent,and significantly decreased to(7.25±4.82)and(6.70±4.90)after 3 and 6 months treatment(P<0.01); the heart rate(HR) was (76.40±12.06) beats per minute(bpm)before self-treatment,and dramatically decreased to (69.95±12.63),(67.15±9.76)bpm after 3 and 6 months treatment(P<0.01).As for UCG detecting index,left atrial diameter(Lad)aIld left ventricular end-diastolic diameter(LVEDd)Was(37.85 ±5.23)nun and(52.49± 9.38)mm separately before self-treatment,and notablely decreased to(36.77 ±5.63),(52.15 ±9.24)mm,and (35.29±5.50),(50.81±8.88)mm respectirely after 3 and 6 months of treatment(P<0.01 or<0.05);left ventricuIar ejection fractiOII(LVEF)markedly increased(P<0.05),from(55.15±15.80)%at baseline to(57.35± 12.51)%at 3 months and(60.30±13.42)%at 6 months;there were no significant differences in mitral flow E/A ratio changes before and after treatment(P>0.05);compared with prior to the treatment.cardiac function grading was significantly better aftertreatmentfor 3 months(T=36.0,P<0.05),but not after 6 months(T=17.5,P> 0.05).Conclusions The patients'serf-treatment is effective,which we recommend to uphold and widespread.
4.Evaluation of effects of self-treatment on patients with Keshan disease by echocardiography
Zhong-yu, MA ; Jing-yuan, YANG ; Tong, WANG ; Hong, LIU ; Hong-qi, FENG ; Jun-rui, PEI ; Bai-nan, XU ; Yue, LIU ; Gai-gai, ZHANG ; Zi-dan, GUO
Chinese Journal of Endemiology 2008;27(4):446-448
Objective To observe the change in cardiac shape and heart function and evaluate the effect of self-treatment on patients with Keshan disease by echocardiography. Methods To check the 31 patients with Keshan disease before the self-treatment, and follow them up in the 3rd and 6th months after self-treatment by echocardiography. The left atrium diameter(LAd), left ventricular end-diastolic diameter(LVEDd), the thickness of interventricular septum in end-diastolic(IVSTd), the thickness of LV posterior wall in end-diastolic (LVPWTd), left ventricular mass(LVM), left ventricular mass index(LVMI), left ventricular ejection fraction(LVEF) and mitral valve flow E/A ratio(E/A) were measured. Results The LAd[(35.8±5.1)ram] and LVPWTd[(9.3±1.0)mm] obviously decreased in the 3rd month after serf-treatment compared with prior self-treatment [ (37.0±5.0), (9.9± 1.2)mm](P<0.05). The LAd[(34.5±5.0)mini, IVSTd[(9.5±1.3)mm], LVEDd[(50.2±7.7)mm], LVPWTd [(8.7±1.1)mm], LVM[(196.1±87.2)g] and LVMl[(126.5±56.4)g/m2] obviously decreased in the 6th month after self-treatment compared with prior self-treatment [(37.0±5.0), (10.2±1.5), (51.3±8.1), (9.9±1.2)mm, (230.4±95.5)g, (144.0±54.6)g/m2] and in the 3rd month after self-treatment [(35.8±5.1)mm, (10.2±1.4) ram, (51.1±8.1)nun, (9.3±1.0)mm, (219.4±82.5)g, (136.8±50.0)g/m2] (P<0.05). The results of the mitral valve flow E/A ratio and LVEF in the 3nt month after self-treatment [1.0±0.5, (59.4±13.3)%] were increased compared with the prior self-treatment[0.9±0.5, (58.1±15.6)%], and the results in the 6th month after self-treat- ment[ 1.0±0.4, (60.7±13.6)%] were further inereased compared with before, but there was no signifieant differ- ence(P0.05). Conclusions Self-treatment of Keshan disease patients can improve the heart function by pre- venting left ventrieular remodeling and reversing. Echocardiography can be used as an essential technique to evalu- ate the effect of self-treatment on Keshan disease patients.
5.Study on multi-target optimization of prescription dose of Mahuang decoction.
Yu HE ; Yu-Quan GAI ; Hui-Fen ZHOU ; Yan-Wen SUN ; Wei-Feng JIN ; Hai-Tong WAN
China Journal of Chinese Materia Medica 2014;39(7):1270-1275
OBJECTIVETo optimize the prescription dose of Mahuang decoction in a multi-target manner, in order to provide reference for the quantitative optimization of the prescription dose of the traditional Chinese medicine compound.
METHODThe number of diaphoretic spots in rats, the tracheal antispasmodic rate in guinea pigs and the writhing times by acetic acid in mice were taken as the indexes for evaluating the diaphoretic, antispasmodic and analgesic effects. According to the experimental results of the 16 orthogonal combination prescriptions, a mathematical dose-effect model was built by support vector regression (SVR) and quadratic response surface regression (RSR) respectively. The multi-target optimization was achieved by elitist non-dominated sorting genetic algorithm (NSGA-II) and entropy weight TOPSIS method.
RESULTThe optimal dose of Mahuang decoction after being optimized by SVR modeling contained 17.71 g of Ephedrae Herba, 9.57 g of Cinnamomi Ramulus, 11.75 g of Armeniacae Semen Amarum and 4.39 g of Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle. The optimized result by RSR modeling contained 13.37 g of Ephedrae Herba, 11.61 g of Cinnamomi Ramulus, 11.98 g of Armeniacae Semen Amarum and 5.67 g of Glycyrrhizae Radix et Rhizoma Praeparate Cum Melle. SVR was superior to RSR in both of the forecast capacity and optimization results.
CONCLUSIONSVR-NSGA-II-TOPSIS method could be adopted for the multi-target optimization for the dose of Mahuang decoction and other traditional Chinese medicine compounds. It is proved to be the optimal prescription with the best efficacy, and could provide scientific quantitative basis for determining the dose of traditional Chinese medicine compound prescriptions and developing new traditional Chinese medicines.
Animals ; Cinnamomum ; chemistry ; Drug Compounding ; methods ; Drug Dosage Calculations ; Drug Prescriptions ; Ephedra ; chemistry ; Ephedra sinica ; chemistry ; Glycyrrhiza ; chemistry ; Guinea Pigs ; Mice ; Rats
6.A new SVRDF 3D-descriptor of amino acids and its application to peptide quantitative structure activity relationship.
Jian-Bo TONG ; Sheng-Wan ZHANG ; Su-Li CHENG ; Gai-Xian LI
Acta Pharmaceutica Sinica 2007;42(1):40-46
To establish a new amino acid structure descriptor that can be applied to polypeptide quantitative structure activity relationship (QSAR) studies, a new descriptor, SVRDF, was derived from a principal components analysis of a matrix of 150 radial distribution function index of amino acids. The scale was then applied in three panels of peptide QSAR that were molded by partial least squares regression. The obtained models with the correlation coefficients (R2(cum)), cross-validation correlation coefficients (Q2(cum)) were 0.766 and 0.724 for 48 bitter tasting dipeptides; 0.941 and 0.811 for 21 oxytocin analogues; 0.996 and 0.919 for 20 thromboplastin inhibitors. Satisfactory results showed that information related to biological activity can be systemically expressed by SVRDF scales, which may be an useful structural expression methodology for the study of peptides QSAR.
Amino Acid Sequence
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Amino Acids
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chemistry
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Dipeptides
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chemistry
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pharmacology
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Least-Squares Analysis
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Models, Chemical
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Oxytocin
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analogs & derivatives
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chemistry
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pharmacology
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Peptides
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chemistry
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pharmacology
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Principal Component Analysis
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methods
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Quantitative Structure-Activity Relationship
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Thromboplastin
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antagonists & inhibitors
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chemistry
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pharmacology
7.Analysis of cytogenetic characteristics in patients with myelodysplastic syndrome.
Liang MA ; Ming-Hua ZHONG ; Cheng-Wu HAN ; Jun-Yan WANG ; Yong-Tong CAO ; Yi-Gai MA
Journal of Experimental Hematology 2012;20(6):1405-1409
This study was aimed to investigate the distribution of chromosomal aberrational karyotype in myelodysplastic syndrome (MDS) subgroups, the characterizations of numerical and structural aberration. The chromosome was prepared with simple culture of bone marrow, and the karyotype was analysed by G banding technique. The results showed tht 54 out of 127 patients (42.5%) had clonal chromosome aberrations, and the abnormal rates were different in subgroups: 30% (3/10) in MDS-RA, 35.9% (23/64) in MDS-RCMD, 22.2% (2/9) in MDS-RAS, 45% (9/20) in MDS-RAEB-I, 66.7% (14/21) in MDS-RAEB-II, 100% (3/3) in 5q-syndrome, respectively. Among 54 abnormal chromosome patients, 21 patients showed numerical aberration, 14 patients showed structural aberration, and the other 19 patients showed both numerical and structural aberration. The order of frequent aberrations was as follows complex karyotype (11.02%, 14/127), single +8 (10.24%, 13/127), -7/7q- (3.9%, 5/127), 1q+ (3.15%, 4/127), -X/-Y (3.15%, 4/127), 20q- (2.36%, 3/127), 5q- (2.36%, 3/127). The frequency of complex karyotype in MDS-RAEB (including RAEB-I and RAEB-II) was higher than that in non MDS-RAEB (including RA, RCMD, RAS, 5q-syndrome) (P < 0.05), and the frequency of balanced translocation was lower than that in non-balanced translocation (P < 0.05), and both of the two balanced translocation patients were found in MDS-RAEB. It is concluded that MDS is highly heterogeneous clonal disorder, a great majority of cytogenetic changes can be detected and most of which are recurrent aberrations, balanced translocations are rare, and only found in MDS-RAEB. The frequency of complex karyotype in MDS-RAEB is higher, and the patients with dup (1) (q21q32) recurrent abnormality is common in this study.
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Chromosome Aberrations
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Cytogenetics
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Female
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Humans
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Karyotype
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Karyotyping
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Male
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Middle Aged
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Myelodysplastic Syndromes
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genetics
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Young Adult
8.Effect of time and pressure factors on the cupping mark color.
Xi-xin ZHAO ; Bo-ying TONG ; Xue-xia WANG ; Gai-ling SUN
Chinese Acupuncture & Moxibustion 2009;29(5):385-388
OBJECTIVETo investigate the effects of the factors of time and pressure during cupping treatment on the cupping mark color, so as to provide scientific data and evidence for study on parameters and effect of cupping treatment.
METHODSOrthogonal experimental design was used with 12 stimulating parameters on 3 time levels and 4 pressure levels, cupping was given at 12 sites on the back of a same healthy subject, and 34 persons/times were completed in the experiment. The cupping mark color at each site was assessed 24 hours after cupping with a cupping mark color atlas, and the change law of cupping mark color was analyzed.
RESULTSThere was a significant difference for the different parameters (P < 0.01). The time factor had statistically significant effect on cupping mark color (P < 0.05), showing 10 min >30 min >20 min. The effect of pressure factor on cupping mark color was significant (P < 0.01), showing -0.07 MPa > -0.06 MPa > -0.05 MPa > -0.04 MPa.
CONCLUSIONThe stimulation of 10 minutes and the pressure of -0.04 MPa produces a marked ecchymosis on the cupping site, getting darker and darker along with increase of the stimulation intensity; the effect of pressure factor on cupping mark color is the largest with a linear relationship, which can be expressed as Y (cupping skin color) = 2.025 + 0.902 x 100 x negative pressure absolute value (-MPa); while the effect of time factor on cupping mark color is more complicated, which is possibly related with the cupping site.
Adult ; Female ; Humans ; Male ; Medicine, Chinese Traditional ; methods ; Pressure ; Skin Pigmentation ; Time Factors ; Young Adult
9.Immunophenotype analysis on neoplastic cells in bone marrow and peripheral blood of angioimmunoblastic T-cell lymphoma.
Li-xin ZHANG ; Jun YE ; Tao-hong LU ; Gai-nü JIANG ; Wei XIAO ; Xue-jun ZHU ; Ya-bao CHEN ; Tong-jing XING ; Zheng-dong WU ; Jun-xing HUANG
Chinese Journal of Pathology 2009;38(8):552-554
Bone Marrow Cells
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metabolism
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pathology
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CD28 Antigens
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blood
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metabolism
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CD4 Antigens
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blood
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metabolism
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CD4-Positive T-Lymphocytes
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metabolism
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Dendritic Cells, Follicular
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metabolism
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pathology
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Humans
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Immunoblastic Lymphadenopathy
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metabolism
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pathology
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Immunophenotyping
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methods
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Lymphoma, T-Cell
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metabolism
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pathology
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Neprilysin
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blood
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metabolism
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Receptors, Complement 3d
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blood
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metabolism
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fas Receptor
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blood
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metabolism
10.Study on the sexual development of adolescent male.
Ling GAI ; Dan-Tong YANG ; Hui-Qing SUN ; Guan-Zhao XU ; Yi QIU ; Li-Feng ZHANG ; Zheng-Da REN
National Journal of Andrology 2002;8(5):353-366
OBJECTIVESThe investigation of the testicular volume, the penis length and the T, FSH, LH, PRL levels in serum were taken in 289 adolescent males to provide the valuable data for andrology.
METHODSThe adolescent males were grouped according to their age. The testicular volume was measured with testicular model and the T, FSH, LH, PRL levels in serum were determined by immunoenzymetric assay.
RESULTSThe male sexual development was rapid from age 11 to 16 and close to that of adult at age 18. Serum PRL of adolescent males was higher than that of adult males.
CONCLUSIONSThe age 11 to 16 is a period of rapid growth in sexual maturation. PRL may play an important role in sexual maturation.
Adolescent ; Body Height ; Body Weight ; Gonadal Steroid Hormones ; blood ; Humans ; Male ; Penis ; physiology ; Testis ; physiology