Circadian rhythms (diurnal variations) in many physiological parameters have been reported. However, there are no data on gas exchange kinetics at the onset of exercise. The purpose of this study was to establish whether there are circadian rhythms in gas exchange kinetics at the onset of exercise.
Six male subjects performed 120W exercise on a cycle ergometer for 7 min in the morning (AM; 7: 30-8: 30) and evening (PM; 16: 30-17: 30) . Rectal temperature (Tr) and mean skin temperature (T_sk) at rest were significantly higher PM than AM, the differences being 0.9±0.2°C and 0.7±0.2°C, respectively. Respiratory and circulatory parameters at rest and during exercise were not different between AM and PM. The time constants of oxygen uptake (Vo₂), carbon dioxide output (Vco₂), minute ventilation (V_E), heart rate (HR), and oxygen pulse (Vo₂/HR) showed the same results. There was no relationship between temperature parameters (Tr, T_sk) and the time constants.
It is suggested that circadian rhythms reflected by the change in body temperature do not have any effect on gas exchange kinetics at the onset of moderate bicycle exercise.

Under the condition that entrainment between breathing rate and exercise rhythm was minimized. The limitation for deciding anaerobic threshold (AT) by respiratory frequency (f) was studied. Ten healthy subjects (5 male and 5 female) have volunteered to take part in two incremental cycle exercises (male : 30 watt/2 min, 50 rpm ; female : 20 watt/2 min, 50 rpm) . The subjects were either sedentary or active and performed tests under two different condi-tions. The different conditions are explained below.
1) Condition M : Use a metronome to maintain pedalling frequency so entrainment would easily occur.
2) Condition S : Use a tachometer to maintain pedalling frequency so entrainment would not easily occur.
Oxygen uptake (VO₂) at AT were determined by two different methods. The first method was to detect the point of non-linear increase in minute ventilation (VE) and carbon dioxide output (VCO₂) and then to increase detection in the ventilatory equivalent for O₂ (VE/VO₂) without increasing the ventilatory equivalent for CO₂ (VE/VCO₂) (AT-V) . The second method was to detect inflection in f by multisegment linear regression (AT-CF) . There were no significant differences between AT-V (condition M : 26.0±6.2, condition S : 26.4±6.0 ml/kg/ min) and AT-CF (condition M : 31.6±10.2, condition S : 24.7±10.0 ml/kg/min) . A significant positive correlation between AT-V and AT-CF was observed in condition S (r=0.850, p< 0.05), but not in condition M (r=0.563, p>0.05) . The error between AT-V and AT-CF had individual variations. An error within±5% was observed in only 4 out of 10 subjects. These results suggested that even though the ability to detect AT using f is superior in condition S, f is an inadequate indicator for the AT, though the exercise entrained breathing is minimized.

Background: The aim of this study was to develop the Japanese language version of the Liverpool Care Pathway － Home (LCP－H), and to examine the feasibility of the LCP－H in a pilot study. Methods: LCP－H was administered to cancer patients who were predicted to be in their last few days. We evaluated the achieved care goals of LCP－H. A cross－sectional anonymous questionnaire was administered to home nurses who used LCP－H to evaluate usefulness in using LCP－H. Results: LCP－H was used to 35 patients. The care goals of LCP－H were achieved in almost 80%. The nurses evaluated the usefulness of LCP－H: Providing to continuous end－of－life care each staff, Communication well between home nurses and co－medical home staff, and Education for home nurses with limited experience with end－of－life care. Conclusion: The feasibility of LCP－H was confirmed. Therefore, LCP－H should help home nurses to care for dying patients and their families as guide for end－of－life care in home, and improve the quality of end－of－life care in home. However, because the LCP is now being phased out in the UK, it may be necessary to develop an original education tool to assist in care for dying patients and their families in Japan.

Mohs paste (MP) is a topical treatment that can help relieve the symptoms of self-destructive skin lesions caused by malignant tumors. Despite the potential benefits of MP in improving the quality of life of patients, its use in home-based care is limited due to various obstacles. In this study, we developed a 1-mm-thick MP gauze sheet, which allowed us to apply the MP treatment at home to a patient with breast cancer. After three weekly treatments, the patient’s main symptoms, including itchiness, odor caused by exudates, and mobility issues, showed improvement. By using MP as a sheet, we overcame the obstacles associated with its use, such as alterations in the physical properties and the risk of damage to healthy skin tissue. Additionally, we reduced the treatment duration and need for trained personnel. Our findings suggest that the MP treatment can effectively control the symptoms of patients in home-based care, consistent with prior research.