A 48-year-old man, suspected of erythema annulare centrifugum, was treated by Kampo-medicine. His clinical picture and findings were evidently consistent with those of erythema annulare centrifugum. Skin lesions, chiefly consisted of erythema with a little of exfoliation, were noticed both on the upper abdomen and on the bilateral lumbar regions.
Decoctions of Dai-saiko-to (Da-Chai-Hu-Tang) were mainly used for the treatment, concurrently with Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan). Lumbar eruption comp letely disappeared after one month of the treatment and abdominal one also after four months without any trace of lesions.
The therapeutic mechanism of the skin lesions was briefly considered from both the stand point of “cell pathology” and that of “whole body pathology”.

A 69-year-old housewife with chronic eczema was treated by Kampo-medicine. For about 20 years, she had suffered from episodes of general eruptions every summer. At our outpatient clinic, skin lesions, chiefly consisted of papules with erosions, were noticed on bilateral external surface of the nose, the back of right hand and the back of the neck.
At first, decoctions of Keishibukuryo-gan-ka-Daio was prescribed for one month, and afterwards, Keishibukuryo-gan-ka-Daio Yokuinin for the rest. The lesions was completely improved after two or five months of the treatment, and the other skin lesions appeared on bilateral forearms, disappearing also after two or three months of the same design of the treatment. After the therapy by Kampo-medicine, no skin lesions were noticed at least for more than two years.
The therapeutic mechanism of the skin lesions was briefly discussed from both the stand point of “Cell pathology” and that of “Whole body pathology”.

A 19-year-old girl with atopic dermatitis was treated by Kampo-medicine. At our outpatient clinic, her skin lesions were especially prominent on her face and cervical region, although noticed also on chest, abdomen, cubital and popliteal regions.
At first, decoctions of Byakko-ka-Ninzin-To was prescribed in ordinary quantities of composite materials (crude drugs), and afterwards, the crude drug (Coptis japonica, Makino) was added. To improve facial flush and thirst, quantities of Coptis japonica and Gypsum were gradually increased. After 25 weeks of this therapy, the skin lesions almost disappeared, and afterwards, no remedy was needed at least for more than three years.
The therapeutic mechanism of the skin lesions was briefly discussed from both the stand point of “Cell pathology” and that of “Whole boby pathology”.

We introduce the successful treatment of intractable symptoms of 52-year-old female patient with HTLV-I-associated myelopathy (HAM) by Kampo medicine. She showed spastic paraplegia, urinary incontinence, sensory disturbance of extremities and nocturnal myoclonus.
Neurological examination proved to be hyperactive deep tendon reflexes and positive pathological reflexes in legs. The viral antibody titer of HTLV-I was elevated both in cerebrospinal fluid and serum. After treatment with Sho-saiko-to, symptoms were improved. The effect is considered to be immunomodulation of Sho-saiko-to.

The effectiveness of Shakuyaku-kanzo-to on myotonia in a 50-year-old female with myotonic dystrophy is reported. Neurological examination showed myogenic distal dominant muscle weakness and myotonia. Treatment with Shakuyaku-kanzo-to improved myotonic time from 12.8 to 6.8 seconds. This effect was equal to phenytoin and mexiletine. The results indicated that Shakuyaku-kanzo-to affected the ion channels of the skeletal muscle membrane. The apaminsensitive K channel was speculated to be the affected site of the ion channel. Glycyrrhizin might play an important role in this mechanism.
Five week treatment with Shakuyaku-kanzo-to showed no adverse effects on the myopathy.

A 31-year old woman with pustulosis palmaris et plantaris was treated by Kampo-medicine. At our outpatient clinic, her skin lesions were especially prominent on her calcaneal and plantal regions of both feet, although noticed also on her palmar regions of both hands.
Decoctions of Keishi-ka-Ôgi-Tô was prescribed according to her Shô (signs and symptoms on whole body). Pustules apparently increased in 2 weeks after this therapy, but afterwards decreased. After 4 months, the skin regions almost disappeared. Although a slight, transient recurrence was noticed at the 10 months of this therapy, the disease was almost completely healed after 12 months.
The therapeutic mechanism of the skin lesions was briefly discussed from both the stand point of “Cell pathology” and that of “Whole body pathology”.