1.Successful Staged Repair of an Anomalous Origin of the Right Pulmonary Artery from the Ascending Aorta.
Toshihiro Funatsu ; Hidefumi Kishimoto ; Hiroaki Kawata ; Takuya Miura ; Takayoshi Ueno ; Shigemitsu Iwai ; Masamichi Ono ; Tomoko Kita ; Toru Nakajima ; Takeshi Nakada
Japanese Journal of Cardiovascular Surgery 2000;29(1):25-28
We report a successful staged repair of anomalous origin of right pulmonary artery from the ascending aorta in a neonate. A two-day-old girl, who suffered from severe circulatory failure, was admitted. In spite of all medical treatment, acidosis and systemic hypotension developed. Right pulmonary artery banding was performed in an emergency procedure, resulting in immediate elevation of systemic blood pressure. Definitive operation was subsequently performed on the 48th day after birth. The right pulmonary artery, which was de-banded and divided from aorta, was anastomosed directly to the pulmonary trunk in a side-to-end manner. The postoperative course was uneventful and the pulmonary artery pressure was within the normal range.
2.Effect of Squeezing Force on the Extraction of Tablets from Press through Packs (PTPs)in the Selection of Commercial Drug Products
Harunori TAKESHITA ; Saori KITA ; Tomoko WAKABAYASHI ; Arisa YABUTA ; Aya INO ; Yuki HARADA ; Motoko NAKAGAWA ; Michiaki NAKAGAWA ; Takashi HATAE ; Tsuneo HAMAGUCHI
Japanese Journal of Drug Informatics 2018;20(2):98-103
Objective: Difficulty in extracting tablets from a press through pack (PTP) is believed to reduce prescription drug compliance. This is a particularly serious issue for the elderly or for those who have physical disabilities affecting the fingers. In this study, the squeezing force necessary to extract tablets from PTPs was measured for 33 commercial tablet products using a force gauge (FG). Additionally, a sensory test was conducted to determine the degree of difficulty in extracting tablets from PTPs by squeezing, and the correlation between the difficulty measure and squeezing force was evaluated.Methods: The squeezing force for 33 products was measured by FG. The sensory test was conducted with 64 subjects. Four products, each with a different squeezing force, were used for the sensory test. In the test, each subject ranked the products in order according to the amount of force required to extract the tablets. Each product's total score was used in the statistical analysis.Results: The average squeezing force of the 33 products was 33.1 ± 6.9 〔N〕, and significant differences were observed among the products. The sensory test revealed that each subject could significantly distinguish the amount of force required to extract the tablets from each product.Conclusion: A positive correlation was observed between the squeezing force obtained using FG and the results from the sensory test. This suggests that squeezing force can be used as an indicator for the usability of the product. Therefore, the degree of difficulty in extracting tablets from PTPs should be considered when selecting drugs for the elderly.