Therapeutic effects of two methods (1) an acupuncture technique using superficial needling applied during exhalation in the sitting position and (2) a low output laser irradiation technique applied during exhalation in the sitting position, were studied using an indicator represented by the distance between the finger tip and floor obtained when a subject bends forward from the standing position.
1. The acupuncture technique using superficial needling applied during exhalation in the sitting position significantly improved the distance between the finger tip and floor as compared with that before application (p<0.05).
2. The low output laser irradiation technique applied during exhalation in the sitting position improved the distance between the finger tip and floor as compared with that before application (p<0.01). No significant difference in the distance between the finger tip and floor were observed in the non-irradiated group.
3. Considering the therapeutic effects from application at various regions of the body, the acupuncture technique improved the distance between the finer tip and floor when it was applied to Waiguan (TE5) (p<0.05) and Zusanli (S36) (p<0.02)

The purpose of this study was to determine if Moxibustion stimulus influence on the circulation in the sacral area.
In the first phase of this study, the influence of indirect Moxibustion stimulus (using‹SEN-NEN-KYU›) on the amount of blood flowing to the sacrum was investigated using laser Doppler Perfusion Imager PeriScan PIM II.
Significant increase in the amount of blood flow in radial directions were observed around the area where Moxibustion was applied. Immediately after the stimulus, significant differences in the amount of blood flow were observed within 2.5cm to the right and left and 1.5cm above and below the stimulated spot.
With increasing time after the Moxibustion stimulus, the amount of blood flow gradually decreased concentrically returning to the original state over time. However, the amount of blood flow at the Moxibustion spot was significantly higher than the original state 32 minutes and 52 seconds after the Moxibustion treatment.
Increased blood flows to pressure ulcers area induced by Moxibustion stimulus are considered to restrict or arrest the progress of pressure ulcers (according to Stage I of the International Association for Enterostomal Therapy (IAET) classification) on in-home care.

In this paper we introduce recent developments in the studies of brain activation during somatosensory stimulationexploiting new technologies. Somatosensory stimulation such as acupuncture, inauces tocai activation in tne central nervous system. The electroencephalogram is a popular method to investigate this activation, however, it is difficult to identify the exact location of the activation site. Recent new technologies may provide more accurate localization. Besides magnetoencephalography (MEG), which recognizes the activated brain areas by an evoked magnetic field with induced current, two other methodologies, which take advantage of physiological phenomena occurring during brain activation, were used in this functional study. Following excitation of neurons, brain tissue is supplied with oxygen from oxyhemoglobin causing oxyhemoglobin to turn into deoxyhemoglobin. As a consequence deoxyhemoglobin increases in the brain tissue. In the near-infrared spectrum, the deoxyhemoglobin absorption peak shows higher signal intensity than that of oxyhemoglobin, for which reason activated brain areas can be identified by absorption maps. In functional magnetic resonance imaging (fMRI) activated area can be revealed with high spatial resolution due to the change in magnetic susceptibility of deoxygeneated blood. This paper describes fMRI studies employing these three methods for the evaluation of experiments using acupuncture for focal brain activation.

It has been five years since TC 249 was established as a new Technical Committee (TC) at the International Organization for Standardization (ISO), specializing in the field of Chinese traditional medicine. In the second Plenary Meeting held in Den Haag (2011), five working groups (WGs) were established within the TC, two of which specialize in standard development of acupuncture needles (WG3) and other medical devices used in traditional medicine (WG4). Japanese delegates have participated in the discussion within these WGs, paying close attention so as to keep the proposals under discussion consistent with existing Japanese standards and certification standards regulated by the Ministry of Health, Labour and Welfare. However, since most of the participants in TC 249 are clinicians or researchers engaged in medical practices, and not experts on domestic/international standards, discussions on harmonization of the submitted projects often become complicated. In this manuscript, four experts (two from academia and two from companies that manufacture acupuncture needles and moxibustion devices) who attended the fourth plenary meeting held in Durban, South Africa, in May 2013, report on the stage of progress of standardization development in WG3and WG4.

[Objective] The purpose of this study was to investigate the effects of acupuncture on exercise-induced prolongation of information processing and decrease in attentional resource allocation, excluding the placebo effect.[Design] Crossover, double-blind randomized controlled trial[Settings] Tokyo Ariake University[Subjects] Fifteen healthy men aged 21.1 ± 0.9 years[Methods] We used a handgrip exercise for exercise loading. The handgrip was maintained for six seconds at an intensity of 40% of the maximal voluntary contraction (MVC), followed by rest for four seconds. This was alternately repeated and continued until the subject was incapable of exerting a grip strength of 40% of the MVC. To induce P300, an auditory oddball paradigm was used, and P300 was measured before and after the handgrip exercise. In the same subjects, thumbtack needle (TN) intervention (TN group) and placebo thumbtack needle (PTN) intervention (PTN group) were performed in random order. TN or PTN was applied to ST36, HT7, and GV14 before the handgrip exercise. After the experiment, we asked the subjects and practitioner about the intervention (TN or PTN). The allocation was conducted by a third party who did not participate in the experiment, and the subjects, practitioner, and measurer completed a series of all the experiment procedures and were blinded to the results.[Outcomes] The indicators for measuring the main outcomes were P300 latency and amplitude. reaction time, and masking were indicators for secondary outcomes. [Results and Conclusion] In the PTN group, P300 latency was increased significantly and P300 amplitude was decreased significantly after the handgrip exercise. In the TN group, no significant changes were observed in P300 latency and amplitude after the handgrip exercise. In both groups, reaction time was considerably slower after the handgrip exercise. The k value indicating the degree of agreement between the actual (genuine or placebo) and guessed intervention assignment was k = -0.06 for the practitioner and k = 0.66 for the subjects. No adverse events were found in this study.[Conclusions] The index changes in the TN and PTN in this study were the same as in our previous studies, and acceptable reproducibility was observed. However, the k values indicated that subject masking was inadequate. In the future, the reliability and validity of PTN must be investigated further.

PURPOSE: Bupivacaine is commonly used for the treatment of back pain and the diagnosis of its origin. Nonunion is sometimes observed after spinal fusion surgery; however, whether the nonunion causes pain is controversial. In the current study, we aimed to detect painful nonunion by injecting bupivacaine into the disc space of patients with nonunion after anterior lumbar interbody fusion (ALIF) surgery for discogenic low back pain. MATERIALS AND METHODS: From 52 patients with low back pain, we selected 42 who showed disc degeneration at only one level (L4-L5 or L5-S1) on magnetic resonance imaging and were diagnosed by pain provocation on discography and pain relief by discoblock (the injection of bupivacaine). They underwent ALIF surgery. If the patients showed low back pain and nonunion 2 years after surgery, we injected bupivacaine into the nonunion disc space. Patients showing pain relief after injection of bupivacaine underwent additional posterior fixation using pedicle screws. These patients were followed up 2 years after the revision surgery. RESULTS: Of the 42 patient subjects, 7 showed nonunion. Four of them did not show low back pain; whereas 3 showed moderate or severe low back pain. These 3 patients showed pain reduction after injection of bupivacaine into their nonunion disc space and underwent additional posterior fixation. They showed bony union and pain relief 2 years after the revision surgery. CONCLUSION: Injection of bupivacaine into the nonunion disc space after ALIF surgery for discogenic low back pain is useful for diagnosis of the origin of pain.
Back Pain ; Bupivacaine* ; Diagnosis ; Humans ; Intervertebral Disc ; Intervertebral Disc Degeneration ; Low Back Pain* ; Magnetic Resonance Imaging ; Methods ; Spinal Fusion ; Spine

Objective: Confirmation by pharmacists of brought-in drugs is not only limited to identification of drugs, but also requires prescription design and proposals based on the background of patients and evaluation of associated information. In this study, we analyzed the content of brought-in drugs related PreAVOID reports in our hospital according to the years of pharmacist experience in order to help educate pharmacist for better brought-in drugs confirmation.Method: Various interventions regarding brought-in drugs were compared between two groups: pharmacists with >6 years of experience (group H) and those with < 5 years of experience (group L). PreAVOID reports, which related to drugs brought in by patients admitted to the Ogaki Municipal Hospital between April 1, 2018 and March 31, 2019 were assessed.Result:The PreAVOID reporting rate for the number of brought-in drugs confirmed was higher in group H (1.56%) than in group L (1.12%) (odds ratio 1.399, p = 0.023). The PreAVOID reporting rate when reporting was based solely on prescription information did not differ between these two groups, but when patient background, including disease-related information, was included with prescription information, the rate was higher in group H (0.80%) than in group L (0.30%) (odds ratio 2.725, p < 0.001). Group H provided more reports related to unnecessary drugs.Conclusion: The involvement of pharmacists in the evaluation of brought-in drugs is important when reviewing subsequent medical treatments. Our findings suggest that to improve the quality of treatment, it is necessary to provide appropriate newcomer education, such as conducting case studies using PreAVOID cases.

BACKGROUND/AIMS: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients. METHODS: We conducted a randomized, double-blind placebo-controlled study. Thirty-four female patients with mild to moderate constipation were randomly assigned to either placebo (n = 17) or MgO group (n = 17) 0.5 g × 3/day for 28 days. Primary endpoint was overall improvement over the 4-week study period. Secondary endpoints were changes from baseline in spontaneous bowel movement (SBM), response rates of complete spontaneous bowel movement (CSBM), stool form, colonic transit time (CTT), abdominal symptom, and quality of life. RESULTS: One patient failed to complete the medication regimen and was omitted from analysis: data from 16 placebo and 17 MgO patients were analyzed. The primary endpoint was met by 25.0% of placebo vs 70.6% of MgO group (P = 0.015). MgO significantly improved SBM changes compared to placebo (P = 0.002). However, MgO did not significantly improved response rates of CSBM compared to placebo (P = 0.76). In addition, MgO significantly improved Bristol stool form scale changes (P < 0.001) and significantly improved CTT compared to the placebo group (P < 0.001). MgO significantly improved the Japanese version of the patient assessment of constipation quality of life (P = 0.003). CONCLUSION: Our placebo-controlled study demonstrated that MgO was effective treatment for improving defecation status and shortened CTT in Japanese CC patients with mild to moderate symptoms.
Asian Continental Ancestry Group ; Colon ; Constipation ; Defecation ; Double-Blind Method ; Female ; Humans ; Japan ; Magnesium Oxide ; Magnesium ; Quality of Life ; Therapeutic Uses