Objective　To synthesize and label a tumor positive imaging agent 18F-fluorouracil (FU) and the animal study on the product was also undertaken. Methods　18F-FU was synthesized and labeled. Its biodistribution analysis was done on normal and tumor bearing nude mice. PET imaging was performed on normal and tumor bearing rabbits. Results　HPLC analysis and other quality control test results guaranteed the possibility of animal study and clinical usage of 18F-FU. Biodistribution analysis and PET imaging also demonstrated a high accumulation of the tracer in tumor tissue. Conclusion　18F-FU is a kind of potential tumor positive imaging agents which can be used to assess the effects of chemotherapy.

We reported a rare case of myxoma originating from the anterior leaflet of the mitral valve. A 65-year-old woman was admitted with sympotomes of easily fatigability and palpitation. On auscultation, a grade II/IV systolic murmur was audible at the apex. Echocardiography demonstrated a dense mass arising from the anterior mitral leaflet. The tumor (16×13×10mm in size) was resected from the anterior leaflet of the mitral valve. There was no definite evidence of a tumor stalk on the mitral valve nor valve regurgitation after the operation. Microscopically, polyhedral cells were recognized, indicating myxoma. The postoperative course was uneventful and no recurrence has been noticed during the past 6 years.

STUDY DESIGN: Retrospective case series. PURPOSE: To calculate the prevalence of L5-S1 intervertebral disc degeneration (IDD) by evaluating gynecological disease findings, obtained by pelvic magnetic resonance imaging (MRI), and reveal the risk factors for IDD by analyzing its relationship with age, sacral structure, body mass index (BMI), number of deliveries, and intrapelvic space-occupying lesions. OVERVIEW OF LITERATURE: Age, obesity, height, smoking history, occupation, and lumbosacral structure are reportedly the main factors of lumbar IDD. However, in women, the relationship of IDD with obstetric and gynecological history is unclear. METHODS: The presence of L5-S1 IDD was evaluated on sagittal T2-weighted pelvic MRI during gynecological evaluations in 660 Japanese women. We measured the sacral table angle (STA), sacral kyphosis angle (SKA), and intrapelvic space-occupying lesion size. Age, height, weight, BMI, number of deliveries, lumbosacral structure, size of space-occupying lesions, and presence of uterine leiomyoma based on medical records were compared between the IDD-positive and IDD-negative groups. RESULTS: Lumbosacral IDD was observed in 405 cases (61.4%), and its prevalence increased with age. Differences in age, height, weight, BMI, and number of deliveries between the IDD-positive and -negative groups were significant, but differences in STA, SKA, and presence of uterine leiomyoma and space-occupying lesion size were not. Logistic regression analysis indicated that age, BMI, and STA were risk factors for lumbosacral IDD. CONCLUSIONS: Age is the biggest risk factor for lumbosacral IDD in Japanese women, with BMI and STA also contributing to its development. However, SKA and obstetric and gynecological history were not significantly involved.
Asian Continental Ancestry Group* ; Body Mass Index ; Female ; Humans ; Intervertebral Disc Degeneration* ; Kyphosis ; Leiomyoma ; Logistic Models ; Magnetic Resonance Imaging* ; Medical Records ; Obesity ; Occupations ; Prevalence ; Reproductive History ; Retrospective Studies ; Risk Factors ; Smoke ; Smoking