The nuclear magnetic resonance (NMR) thermal control subsystem described in this paper is a newly developed platform-based thermal management solution. It presents critical challenges in system architecture design and core component selection. Therefore, it is necessary to carry out sufficient reliability design and verification work in the design and development stage to ensure its high quality and high reliability. Firstly, based on the statistical and analytical calculation of the client installation data of the benchmark product, the reliability metric of the new research subsystem is determined, and its usage and environmental profile are defined. Secondly, for the reliability metric to be verified, the test based on reliability growth and reliability demonstration is planned and implemented. A customized test platform is built, relevant reliability test parameters are designed, and a long-term test monitoring and recording mechanism is established to ensure the high-quality implementation of reliability tests. Finally, a detailed analysis is carried out on the design defects and failure modes exposed during the reliability test, and corresponding control measures are proposed to achieve the engineering goal of improving product robustness throughout its life cycle.
Equipment Design ; Magnetic Resonance Spectroscopy/instrumentation* ; Reproducibility of Results

Rosacea is a chronic facial inflammatory skin disease. It has been proved that heredity, immunity, neurovascular disorders, microorganisms, skin barrier damage and ultraviolet rays are closely related to the occurrence of rosacea. However, the exact pathogenesis of rosacea has not been fully elucidated. This review summarizes recent advances in the pathogenesis of rosacea in the past 5 years.

Neonatal hypoglycemia is one of the most common metabolic conditions in newborns.A considerable proportion of newborns are evaluated to be at risk of hypoglycemia，and transitional hypoglycemia is common in healthy newborns.A correlation between severe and prolonged hypoglycemia and neonatal hypoglycemic brain damage（HBD）in newborns has been proven.Factors such as hypoglycemia，glucose reperfusion，and blood glucose fluctuations are all involved in the damage process of HBD to a certain extent.This article reviews the relevant definitions of neonatal hypoglycemia，the characteristics of neonatal blood glucose metabolism，the related mechanisms of HBD，and possible treatment strategies to improve its prognosis.

Glutamine (Gln) is the most abundant free amino acids in the body, is the main substrate of intestinal cells. It exerts its repairing effect on intestinal injury through multiple signaling pathways, mainly reflected in maintaining the integrity of intestinal structure, enhancing the function of the intestinal barrier, improving the intestinal ecology, and promoting the absorption of nutrients. Therefore, it is also gradually popularized in the clinical application of intestinal injury. This summarize will summarize the latest research progress on the biological role of Gln, its relationship with intestinal injury, mechanism of action and clinical application.The main purpose of this summarize is intended to explore the research status and development prospects of Gln in the field of intestinal diseases.

Objective:To investigate the mediating effect of spiritual health between emotional intelligence and humanistic care ability of nursing undergraduates, and to provide reference for cultivating humanistic care ability of nursing undergraduates.Methods:From May to July, 2023, the nursing undergraduates from Hunan University of Traditional Chinese Medicine, Hunan Normal University, Xi'an Medical College were selected as the research objects by convenient sampling method, and they were investigated by general information questionnaire, spiritual health scale, emotional intelligence scale and humanistic care ability scale.Using AMOS 29.0 to construct a structural equation model, this paper explored the mediating effect of spiritual health between emotional intelligence and humanistic care ability of nursing undergraduates.Results:Finally, 1 126 valid questionnaires were collected. Among 1 126 nursing undergraduates, there were 229 males and 897 females. The total scores of spiritual health, emotional intelligence and humanistic care ability of nursing undergraduates were (90.60 ± 11.02), (126.01 ± 11.90), (174.27 ± 15.16) points, respectively. The humanistic care ability of nursing undergraduates was positively correlated with spiritual health and emotional intelligence ( r=0.441, 0.417; both P<0.01), emotional intelligence and spiritual health were positively correlated ( r=0.397, P<0.01). Spiritual health had some mediating effects between emotional intelligence and humanistic care ability, and the amount of mediating effects was 32.24%. Conclusions:The humanistic care ability of nursing undergraduates is at a medium level, and emotional intelligence can influence humanistic care ability through spiritual health. Therefore, it is suggested that nursing educators should add courses and practical activities related to spiritual health in the training plan of nursing students to promote their emotional intelligence and humanistic care ability.

The monitoring unit used in the nuclear magnetic resonance system,as an important unit of the system,faces a high thermal risk during its entire life cycle.This paper ensures the high efficiency and reliability of the thermal design of the product module from the two dimensions of structural design and device derating design.In order to reduce the risk of thermal design of electronic modules and comprehensively verify the effectiveness of thermal design of electronic modules,the design verification is carried out by combining simulation and experiment.In the simulation process,by establishing a thermal simulation model at the circuit board level,the crustal temperature of the core device is numerically calculated,and the index is compared with the thermal design index value and the test value,on the one hand,to verify the correctness of the simulation model.On the other hand,the validity of thermal design is verified.In the testing process,a thermal test platform for product modules is built,and the thermal characteristics test values of the core components of the module under extreme electrical conditions are obtained,and the corresponding conversion methods are used to predict the thermal performance and thermal design margin of the product at different altitudes.The results show that the electronic module can meet the thermal design requirements in terms of structural design and derating design of core components,and can ensure that the product module can work safely and reliably during the entire life cycle of the NMR system.

Objective:To conduct visual analysis of neonatal hospice care based on Web of Science database and explore the research hotspots and frontiers, so as to provide reference for the development of neonatal hospice care in China.Methods:The literatures related to neonatal hospice care included in the core collection of Web of Science from 1991 to 2023 were retrieved and screened. CiteSpace 6.1.R6 was used for visual analysis from the aspects of author, country/region, institution, journal co-citation frequency, keyword knowledge map and so on.Results:A total of 1 452 articles were included, and the number of articles was on the rise. The United States, the United Kingdom and Canada occupied the core position of neonatal hospice care related research. Research hotspots included hospice care for different stages and types of diseases, key links in neonatal intensive care unit hospice care, innovation in neonatal hospice care service models, the needs and psychological support strategies of family members and medical staff. The forefront of research focused on the role and challenges of healthcare professionals in hospice care, disease diagnosis and ethical dilemmas related to decision-making.Conclusions:China can learn from international research hotspots and frontiers to explore the applicability of different hospice service models, enrich research types, strengthen guidance at the level of laws and policies, improve education and training systems and build a neonatal hospice service system that conforms to national conditions and culture in China.

Objective:To explore the clinical efficacy of chemoembolization with doxorubicin-infused gelatin sponge microparticles in the amelioration of arterioportal shunting (APS) in patients afflicted with hepatocellular carcinoma (HCC).Methods:A retrospective investigation was conducted on 9 HCC patients admitted between January 2020 and December 2022 with concomitant moderate-to-severe APS who underwent GSM-transarterial chemoembolization (TACE). Hepatic artery digital subtraction angiography (DSA) was employed to ascertain the magnitude of improvement in arteriovenous shunts, utilization of modified response evaluation criteria in solid tumors facilitated the appraisal of short-term clinical outcomes. Follow-up records documented survival duration, along with quantitative parameters such as the longest diameter of tumor lesions and serum alpha-fetoprotein (AFP) levels before and after treatment. The Wilcoxon rank-sum test was utilized to compare the differences of these quantitative parameters before and after treatment.Results:The APS amelioration rates were 100% and 88.9% at immediate and recent postoperatively, respectively. The oncological response rate was 77.8% (7/9), and the complete necrosis rate was 22.2% (2/9) at three months postoperatively, the 1-year survival rate was 100%. Following treatment, a significant reduction was observed in the tumor′s longitudinal diameter [4.32(3.88,6.63)cm] and serum AFP levels [13.50 (7.55, 29.60) μg/L], compared to the pre-treatment values of the tumor′s longitudinal diameter [5.20(4.58,8.57)cm] and serum AFP levels [524.30 (320.65, 1 046.15) μg/L] ( P<0.05 for all). Conclusion:Doxorubicin-infused GSM-TACE is both feasible and efficacious in the first treatment of HCC concomitant with APS and represents a better clinical alternative.

As the severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)pandemic continues to spread globally,its genome is undergoing mutations and evolution,giving rise to various strains such as α,β,γ,and δ.Therefore,the continuous development of drugs and vaccines targeting the various strains has become pivotal to addressing the COVID-19 pandemic.Establishing animal models of SARS-CoV-2 enables study of the pathogenesis of the virus and is crucial for evaluating the efficacy of drugs and vaccines against SARS-CoV-2.However,commonly used animal models such as mice exhibit limited susceptibility to wildtype SARS-CoV-2 infection,underscoring the urgent need for animal models that can be infected with the novel coronavirus and better simulate the human pathological and physiological conditions.This review summarizes the animal models used to study SARS-CoV-2 infection and transmission,and their progress in characterizing the viral immunopathology.

Objective:To understand the cognition and attitude of medical staff towards medical ethics review, analyze possible influencing factors, to put forward relevant suggestions for strengthening ethical management in the future.Methods:From November 2021 to May 2022, a self-designed questionnaire and general data questionnaire on the cognition and attitude of medical staff to ethical issues in clinical research were used to investigate 408 medical staff from two first-class ternary hospitals in Hunan Province, data was analyzed to explore the respondents′ cognition and attitude, as well as related influence factors.Results:The average cognitive score of medical staff was 65.41, and the average attitude score was 91.83. Many possible influence actors regarding the cognition were identified, including degree, technical title, professional field, number of clinical research projects engaged as investigators, number of clinical research projects conducted as principle investigators, whether the hospital has established an ethics committee, and research ethics training experiences. While the influence factors of attitude were experiences of conducting and engaging in clinical research, the construction of hospital ethics committee and research ethics trainings.Conclusions:Medical staffs have the willingness to explore more research ethics knowledge, while their cognition of research ethics should be improved. Root-cause analysis should be conducted to identify influencing factors for improvement. The research management department should strengthen the publicity and training of clinical research ethics of medical staff, to improve their clinical research ethics knowledge literacy, and ensure the well-functioning of clinical research ethics review.