1.Content Determination of Aconitine-type Alkaloids in Bitongxiao Ointment by Acid-dye Colorimetry
Dake CAI ; Geng LI ; Shaozhong PENG ; Yaohui HE ; Zhongze LIN ; Tingwei GU ; Ziren SU
Traditional Chinese Drug Research & Clinical Pharmacology 1993;0(01):-
Objective To determine the content of aconitine-type alkaloids in Bitongxiao Ointment,and to control the limits of aconitine-type alkaloids in the ointment.Methods Acid-dye colorimetry was employed and methodology was examined for linear range,average recovery,precision,exclusivity and stability.Results The method has a good precision and stability.The linear range of aconitine-type alkaloids was in 0.111 9~0.714 mg(r=0.999 3),and the average recovery was 97.4 %.Conclusion The method is accurate,reliable,simple,can be used to determine the content of aconitine-type alkaloids in Bitongxiao Ointment.
2.Extremely mild cholesterol side chain cleavage enzyme deficiency with infertility as the only presenting complaint
Shouyue SUN ; Lei YE ; Jieli LU ; Weiqiong GU ; Tingwei SU ; Jing XIE ; Xiaoyi ZHOU ; Rulai HAN ; Weiqing WANG ; Guang NING
Chinese Journal of Endocrinology and Metabolism 2016;32(7):607-610
[Summary] All patients with cholesterol side-chain cleavage enzyme ( P450scc) deficiency that have been reported presented with early adrenal failure. Here we described a 35-year-old male presented with infertility as the only initial presenting complaint. He had received two separate surgeries to remove bilateral testicular masses. We reevaluated the resected tumors and found testicular adrenal rest tumor ( TART) pathology in the resected tumor. We profiled steroid hormones and found significantly elevated ACTH. CT scan revealed bilateral adrenal hyperplasia. Mutation screening identified compound heterozygous mutations (R353W and P432L) in the P450scc encoding gene (CYP11A1). The patient was finally diagnosed as congenital adrenal hyperplasia.
3.Advances in the pathogenesis of rosacea
Tingwei LIU ; Xiaoqi MENG ; Duoduo GU ; Ruoxin PAN ; Yue ZHANG ; Yang XU
Chinese Journal of Dermatology 2024;57(2):186-190
Rosacea is a chronic facial inflammatory skin disease. It has been proved that heredity, immunity, neurovascular disorders, microorganisms, skin barrier damage and ultraviolet rays are closely related to the occurrence of rosacea. However, the exact pathogenesis of rosacea has not been fully elucidated. This review summarizes recent advances in the pathogenesis of rosacea in the past 5 years.