Objective To find out a sesirable approach through which orbital or orbitocranial neoplasma can be resected more effectively. Methods A retrospective study was made on microsurgical resection of 32 cases orbital or orbitocranial neoplasma treated. All patients showed malfunction of optic organs.Microsurgical techniques and different approaches were used to remove neoplasmas. Results Twenty-sevencases received total removal,4 cases subtotal resection, 1 case no resection and 15 cases' skull bases were reconstructed.No postoperative morbidity was found. Conclusions Microsurgical techniques as well as disirable or combined approaches may increase the possibility to resect the total neoplasma and improve clinical results.The reconstruction of skull base should be much emphasized on preventing complications.

Objective To evaluate the relationship of the expressions of proliferating cell nuclear antigen (PCNA) and endocranium invasion in the convex meningiomas.Methods Convex meningioma Simpson I level excises 51 patients were selected.The dural mater 15 mm around the rumors was resected,stochastically divided into four sections (0-1 mm,2-5 mm,6-10 mm,＞10 mm)for pathological inspection.Analysed statistically the study results based on microscopic observation of the HE staining slides and immunohistochemistry of proliferating cell nuclear antigen(PCNA).Results PCNA LI of the group with the endocranium invasion was 10.32±6.74,the other was 2.16±4.93.The atypical meningioma had a high endocranium invasion degree.Conclusion Pathologic grading of meningioma and the expressions of PCNA by immunohistochemical staining method are the factors affecting endoeranium invasion of the convex meningiomas.

Objective To observe the expression of cyclooxygenase(COX)-2 in different malignancy astrocytoma by immunohistochemistry,so as to judge the invasive action of COX-2 in astrocytoma.Methods A total of 55 cases with astrocytoma underwent 63 times operation including 8 recurrent cases were selected,and 9 cases with severe brain injury who needed decompression surgery were selected as control group.The astrocytoma tissues and decompression surgery to remove tissues removed immediately fixed in 10％ formalin buffer solution.The expression of COX-2 was determined by immunohistochemistry.Results The positive expression rate of COX-2 in astrocytoma tissues was higher than that in decompression surgery to remove tissues[69.84％ (44/63) vs.1/9],and there was significant difference (x2 =11.589,P ＜ 0.01).The positive expression rate of COX-2 in recurrent astrocytoma tissues was higher than that in primmy astrocytoma tissues [8/8 vs.65.45％ (36/55)],and there was significant difference (x2 =3.957,P ＜ 0.05).With increased astrocytoma malignancy,the positive expression rate of COX-2 also increased,and there was significant difference (P ＜ 0.05).Conclusion COX-2 may have some relationship with the invasion of astrocytoma,leading to increase tumor grade,and relapse.

Objective:To investigate the predictive value of trigeminal nerve vascular compression grading evaluated by preoperative magnetic resonance imaging (MRI) in patients with trigeminal neuralgia (TN) after microvascular decompression (MVD).Methods:Two hundred and seventy patients with TN accepted MVD in our hospital from January 2015 to December 2017 were chosen in our study; their clinical and MRI data were retrospectively analyzed. By referring to Sindou's method and Jannetta standard, these patients were divided into patients with mild vascular compression ( n=71) and patients with severe vascular compression ( n=199) according to preoperative MRI data; these patients were divided into typical TN patients ( n=219) and atypical TN patients ( n=51) according to their symptomatic characteristics; the differences in prognoses after one year of follow-up were compared among patients from different categories. Results:The degree of intraoperative vascular compression was basically consistent with the preoperative imaging evaluation results, and the intraoperative vascular compression in 256 patients was consistent with preoperative imaging evaluation grading, with a coincidence rate of 94.8% (256/270). The difference in prognosis between patients with mild vascular compression and patients with severe vascular compression was statistically significant ( Z=-3.420, P=0.001), and the mean rank indicated that the prognosis of patients with severe vascular compression was better than that of patients with mild vascular compression (142.01 vs. 117.25). The prognosis difference between typical TN patients and atypical TN patients was statistically significant ( Z=-5.810, P=0.000), and the mean rank indicated that the prognosis of typical TN patients was better than that of atypical TN patients (144.45 vs. 97.08). Conclusions:Preoperative MR imaging evaluation is a reliable method to assess the degree of vascular compression. Patients with severe vascular compression and typical TN have high postoperative pain relief rate after MVD.