Objective To analysis the mental health status of the victims in Wenchuan earthquake. Methods Post-traumatic stress disorder checklist-civilian version (PCL-C), symptom checklist-90 (SCL-90) , Zung' s self-rating anxious scale/depressive scale (SAS/SDS) and simple coping style ques-tionnaires were use to investigate the mental health status of the victims that were transferred to Xinaiao Hospital, Third Military Medical University, one month after earthquake. Results (1) Compared with national ensemble, SCL-90 scores ranked the highest in aspects of somatization and anxiety (t = 3.733, P <0.01; t = 2.368, P < 0.05) but the score of paranoid ideation decreased significantly (t =-3.584, P<0.01), with score over 3 accounting for 20.7%. (2) The proportion of moderate anxiety and depres-sion was 21.7% and 26.0%, respectively. (3) The PCL-C total score was positively correlated with SCL-90 scores and SAS scores (r = 0.642, P < 0.01 ; r = 0.506, P < 0.05), but negatively with negative items in SCL-90(r =-0.681, P <0. 01). (4) Multiple linear regression analysis showed that 36. 6% of variation of PCL-C total score could be forecast by comhining SAS scores with positive copy scores. Conclusions One month after earthquake, more. than 20% of the victims transferred to Xinqiao Hospital have moderate mental health problem and need early mental intervention for improvement in physical and mental health.

Cholesterol is an important precursor of many endogenous molecules. Disruption of cholesterol homeostasis can cause many pathological changes, leading to liver and cardiovascular diseases. CYP1A is widely involved in cholesterol metabolic network, but its exact function has not been fully elucidated. Here, we aim to explore how CYP1A regulates cholesterol homeostasis. Our data showed that CYP1A1/2 knockout (KO) rats presented cholesterol deposition in blood and liver. The serum levels of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and total cholesterol were significantly increased in KO rats. Further studies found that the lipogenesis pathway (LXRα-SREBP1-SCD1) of KO rats was activated, and the key protein of cholesterol ester hydrolysis (CES1) was inhibited. Importantly, lansoprazole can significantly alleviate rat hepatic lipid deposition in hypercholesterolemia models by inducing CYP1A. Our findings reveal the role of CYP1A as a potential regulator of cholesterol homeostasis and provide a new perspective for the treatment of hypercholesterolemia.