Objective To investigate the effect of construction-process-result three-dimensional quality assessment mode in continuing nursing to patients with liver cirrhosis after endoscopic variceal ligation (EVL). Methods Toally 100 patients with liver cirrhosis after EVL hospitalized in the hospital between January 2014 to December 2015, 50 patients among them during January to December 2014 were set as the control group, the other 50 ones during January to December 2015 as the experiment group. The control group only received routine instruction at discharge and those in the experiment group were treated with continuing nursing based on construction-process-result three-dimensional quality assessment mode. Both groups were followed up for six months after discharge and then compared in terms of medication and diet compliance and re-bleeding rate. Result The patients in the experiment group were significantly better than those in the control group (P<0.05) in the medication and diet compliance. Conclusions The construction-process-result three-dimensional quality assessment mode can improve the quality of continuing nursing for the patients with liver cirrhosis after EVL. It can enhance the medication.